云南高校图书馆联盟文献共享服务平台- EQTL

EQTL: 作品数：36被引量：65H指数：4; 导出分析报告; 相关领域：农业科学医药卫生更多>>; 相关作者：沈勤印志同陆璐陈颖许玲莉更多>>; 相关机构：华中农业大学南京农业大学南通大学中国农业大学更多>>; 相关期刊：《Journal of Animal Science and Biotechnology》《Science China(Life Sciences)》《现代生物医学进展》《Quantitative Biology》更多>>; 相关基金：国家自然科学基金国家现代农业产业技术体系建设项目江苏省自然科学基金国家重点基础研究发展计划更多>>

基于eQTL定位筛选乳腺癌免疫相关标志物:孟德尔随机化与转录组学研究: 《右江医学》2025年第2期102-114,共13页何亚玲张鑫吴泽远张平茜叶亚林潘云李艳; 国家自然科学基金(82160044)。; 目的通过表达数量性状位点(eQTL)定位筛选乳腺癌免疫相关分子标志物,旨在为乳腺癌的诊断和治疗寻找潜在靶标。方法对来自GEO数据库的3个乳腺癌数据集进行系统分析,利用eQTL分析确定工具变量(IVs),利用公开的乳腺癌全基因组关联(GWAS)...; 关键词：表达数量性状位点定位乳腺癌孟德尔随机化肿瘤免疫生物标志物

Regulatory networks of coresident subgenomes during rapid fiber cell elongation in upland cotton: 《Plant Communications》2024年第12期178-194,共17页Lan Yang Wenqiang Qin Xi Wei Rui Liu Jiaxiang Yang Zhi Wang Qingdi Yan Yihao Zhang Wei Hu Xiao Han Chenxu Gao Jingjing Zhan Baibai Gao Xiaoyang Ge Fuguang Li Zhaoen Yang; National Key Research and Development Program of China(2021YFF1000102-1 and 2023YFD2301201);Innovation Program of the Chinese Academy of Agricultural Sciences(CAASASTIP-IVFCAAS);Fundamental Research Funds of State Key Laboratory of Cotton Biology(CB2021E03);Key Research and Development Project of Henan Province(231111110400).; Cotton, an intriguing plant species shaped by polyploidization, evolution, and domestication, holds particular interest due to the complex mechanisms governing fiber traits across its two subgenomes. However, the regu...; 关键词：cottonfiber EQTL regulatory network DOMESTICATION

An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs被引量：1: 《Science China(Life Sciences)》2024年第6期1133-1154,共22页Yang Zhang Mengyao Wang Zhenguo Li Xuan Yang Keqin Li Ao Xie Fang Dong Shihan Wang Jianbing Yan Jianxiao Liu; supported by the National Key Research and Development Program of China(2022YFD1201504);the Fundamental Research Funds for the Central Universities(2662022YLYJ010,2021ZKPY018,2662021JC008,SZYJY2021003);the Major Science and Technology Project of Hubei Province(2021AFB002);the Major Project of Hubei Hongshan Laboratory(2022HSZD031);the Yingzi Tech&Huazhong Agricultural University Intelligent Research Institute of Food Health(IRIFH202209)。; Detecting genes that affect specific traits(such as human diseases and crop yields)is important for treating complex diseases and improving crop quality.A genome-wide association study(GWAS)provides new insights and d...; 关键词：gene-trait association GWAS EQTL COLOCALIZATION transcriptome-wide association study(TWAS) Mendelian randomization(MR)

基因组转录调控元件内单核苷酸多态性调控基因表达介导扩张型心肌病: 《中国分子心脏病学杂志》2024年第2期5986-5995,共10页王珍婷曹唱唱; 中国医学科学院医学与健康科技创新工程(重大协同创新项目,项目编号:2021-1-I2M-019)。; 目的探究人类基因组转录调控元件区域单核苷酸多态性与扩张型心肌病发病之间的关联及潜在的致病机制。方法利用心脏组织表达数量性状基因座(expression quantitative trait locus,eQTL)数据与50例扩张型心肌病患者的H3K27ac组蛋白修饰的...; 关键词：扩张型心肌病 CHIP-SEQ EQTL 启动子增强子

Uncovering key salt-tolerant regulators through a combined eQTL and GWAS analysis using the super pan-genome in rice被引量：3: 《National Science Review》2024年第4期49-63,共15页Hua Wei Xianmeng Wang Zhipeng Zhang Longbo Yang Qianqian Zhang Yilin Li Huiying He Dandan Chen Bin Zhang Chongke Zheng Yue Leng Xinglan Cao Yan Cui Chuanlin Shi Yifan Liu Yang Lv Jie Ma Wenchuang He Xiangpei Liu Qiang Xu Qiaoling Yuan Xiaoman Yu Tianyi Wang Hongge Qian Xiaoxia Li Bintao Zhang Hong Zhang Wu Chen Mingliang Guo Xiaofan Dai Yuexing Wang Xiaoming Zheng Longbiao Guo Xianzhi Xie Qian Qian Lianguang Shang; supported by the National Natural Science Foundation of China (32188102 and 32372148);Shenzhen Science and Technology Program (RCBS20221008093339096);Innovation Program of Chinese Academy of Agricultural Sciences,Youth Innovation of Chinese Academy of Agricultural Sciences (Y2023QC36);China Postdoctoral Science Foundation (2023M733839);National Key R&D Program of China(2022YFE0139400); For sessile plants,gene expression plays a pivotal role in responding to salinity stress by activating or suppressing specific genes.However,our knowledge of genetic variations governing gene expression in response to...; 关键词：super pan-genome expression quantitative trait loci GWAS salt tolerance RICE

全基因组eQTL揭示猪11号染色体肉质性状新候选位点被引量：1: 《农业生物技术学报》2024年第4期807-819,共13页郑韵頔冉雪琴牛熙黄世会李升王嘉福; 国家自然科学基金(31960641);贵州省科技创新人才团队项目(黔科合平台人才[2019] 5615);贵州省“百”层次创新型人才培养项目(黔科合人才[2016]4012);贵州省科技支撑计划(黔科合支撑[2017]2585,黔科合支撑[2017]2987);贵州省农业农村厅生猪产业高质量发展计划[202208-5]。; 全基因组关联分析(genome-wide association study,GWAS)挖掘了大量猪肉肉质性状关联的遗传变异,但是多数变异的调控机制未知。遗传变异主要通过调控基因表达水平影响复杂性状,通过定位表达数量性状位点(expression quantitative trait ...; 关键词：猪全基因组测序(WGS) 转录组测序表达数量性状位点(eQTL) SNP 肉质性状

Genetic variants in the 6p21.3 region influence hepatitis B virus clearance and chronic hepatitis B risk in the Han Chinese population: 《Liver Research》2024年第1期54-60,共7页Jiancheng Huang Mingkuan Su Fanhui Kong Hongbin Chen Shuiqing Wu Jianfeng Guo Haiying Wu; funded by The Ningde Science and Technology Plan Project of China(Grant No.20170013).; Background and aim:A genome-wide association study has indicated the association of numerous genes in the 6p21.3 region with chronic hepatitis B virus(HBV)infection.In this study,we screened 12 representative single-n...; 关键词：Chronic hepatitis B(CHB) Expression quantitative trait loci(eQTL) HAPLOTYPE Hepatitis B virus(HBV) Human leukocyte antigen(HLA) Single-nucleotide polymorphism(SNP)

eQTL studies: from bulk tissues to single cells被引量：1: 《Journal of Genetics and Genomics》2023年第12期925-933,共9页Jingfei Zhang Hongyu Zhao; An expression quantitative trait locus (eQTL) is a chromosomal region where genetic variants are associated with the expression levels of specific genes that can be both nearby or distant. The identifications of eQTLs...; 关键词：EQTL Bulk samples Single cell TISSUES Cell-type-specific Context-dependent

The eQTL colocalization and transcriptome‑wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle被引量：1: 《Journal of Animal Science and Biotechnology》2023年第5期1909-1925,共17页Wentao Cai Yapeng Zhang Tianpeng Chang Zezhao Wang Bo Zhu Yan Chen Xue Gao Lingyang Xu Lupei Zhang Huijiang Gao Jiuzhou Song Junya Li; supported by grants from the Central Public-interest Scientific Institution Basal Research Fund(2020-YWF-YB-02);the Young Scientists Fund of the National Natural Science Foundation of China(32202652);China Agriculture Research System of MOF and MARA(CARS-37);the Science and Technology Project of Inner Mongolia Autonomous Region(2020GG0210).; Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle.To prioritize the putative variants and genes,we ra...; 关键词：Cattle COLOCALIZATION eQTL mapping GWAS TWAS

联合多组学数据鉴定猪脂肪沉积的候选基因被引量：1: 《中国畜牧杂志》2023年第8期123-130,共8页刘华涛马福平赵卿尧杨金艳汪佳豪王露露丁向东王楚端; 财政部和农业农村部:国家现代农业产业技术体系;国家重点研发计划项目(2019YFE0106800)。; 脂肪沉积是猪生产及育种中最为重要的经济性状指标之一,其调控机制一直是研究热点,单一组学的研究方法不足以推测与还原出猪脂肪沉积复杂的调控过程。因此本研究联合多组学数据共同进行分析以鉴定猪脂肪沉积的候选基因。首先对同一猪场...; 关键词：大白猪脂肪沉积 eQTL分析 GWAS 共定位分析

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