COLOCALIZATION

作品数：30被引量：39H指数：4
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相关领域：医药卫生生物学更多>>
相关作者：赵志奇熊南翔李云庆向正华陶元祥更多>>
相关机构：第二军医大学第四军医大学清华大学华中科技大学同济医学院附属协和医院更多>>
相关期刊：《Journal of Pharmaceutical Analysis》《National Science Review》《中国生物学文摘》《Journal of Animal Science and Biotechnology》更多>>
相关基金：国家自然科学基金更多>>
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An overview of detecting gene-trait associations by integrating GWAS summary statistics and eQTLs被引量：1
《Science China(Life Sciences)》2024年第6期1133-1154,共22页Yang Zhang Mengyao Wang Zhenguo Li Xuan Yang Keqin Li Ao Xie Fang Dong Shihan Wang Jianbing Yan Jianxiao Liu 
supported by the National Key Research and Development Program of China(2022YFD1201504);the Fundamental Research Funds for the Central Universities(2662022YLYJ010,2021ZKPY018,2662021JC008,SZYJY2021003);the Major Science and Technology Project of Hubei Province(2021AFB002);the Major Project of Hubei Hongshan Laboratory(2022HSZD031);the Yingzi Tech&Huazhong Agricultural University Intelligent Research Institute of Food Health(IRIFH202209)。
Detecting genes that affect specific traits(such as human diseases and crop yields)is important for treating complex diseases and improving crop quality.A genome-wide association study(GWAS)provides new insights and d...
关键词：gene-trait association GWAS EQTL COLOCALIZATION transcriptome-wide association study(TWAS) Mendelian randomization(MR) 
Identification of novel drug targets for diabetic retinopathy:proteome-wide mendelian randomization and colocalization analyses
《Eye Science》2024年第1期26-44,共19页杨少鹏 朱梓瑜 刘日乾 黄文勇 王伟 
funded by the Hainan Province Clinical Medical Center(82171084);the National Natural Science Foundation of China(82371086).
Background:Diabetic retinopathy(DR)urgently needs novel and effective therapeutic targets.Integrated analyses of plasma proteomic and genetic markers can clarify the causal relevance of proteins and discover novel tar...
关键词：plasma proteome mendelian randomization therapeutic targets genome-wide analysis study colocalization analysis diabetic retinopathy 
The eQTL colocalization and transcriptome‑wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle被引量：1
《Journal of Animal Science and Biotechnology》2023年第5期1909-1925,共17页Wentao Cai Yapeng Zhang Tianpeng Chang Zezhao Wang Bo Zhu Yan Chen Xue Gao Lingyang Xu Lupei Zhang Huijiang Gao Jiuzhou Song Junya Li 
supported by grants from the Central Public-interest Scientific Institution Basal Research Fund(2020-YWF-YB-02);the Young Scientists Fund of the National Natural Science Foundation of China(32202652);China Agriculture Research System of MOF and MARA(CARS-37);the Science and Technology Project of Inner Mongolia Autonomous Region(2020GG0210).
Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle.To prioritize the putative variants and genes,we ra...
关键词：Cattle COLOCALIZATION eQTL mapping GWAS TWAS 
Identification of new aptamer BC-3 targeting RPS7 from rapid screening for bladder carcinoma被引量：1
《Genes & Diseases》2023年第5期2137-2150,共14页Yunyi Liu Juan Li Hailong Ou Dan Qi Bei Hu Yuxi Xu Jian Hu Yi Xiong Luling Xia Jason HHuang Xiaoxiao Hu Erxi Wu 
supported by the National Natural Science Foundation of China(No.31970692)(X.Hu);the Corbett Estate Fund for Cancer Research(USA)(No.62285-531021-41800,62285-531021-51800,62285-531021-61800,and 62285-531021-71800)(E.Wu).
Aptamers,short single DNA or RNA oligonucleotides,have shown immense application potential as molecular probes for the early diagnosis and therapy of cancer.However,conventional cell-SELEX technologies for aptamer dis...
关键词：Bladder cancer Cell-SELEX Clathrin-mediated endocytosis Intracellular colocalization Ribosomal protein S7 X-aptamer selections 
Gaining access to acetyl-CoA by peroxisomal surface display
《Synthetic and Systems Biotechnology》2023年第2期224-226,共3页Thomas Perrot Sebastien Besseau Nicolas Papon Vincent Courdavault 
funding from the EU Horizon 2020 research and innovation program(MIAMi project-Grant agreement N°814645);ARD-CVL Biopharmaceutical program of the Region Centre Val de Loire(ETOPOCentre project),Le Studium Institute(Consortium Fellowship)and ANR(project MIACYC-ANR-20-CE43-0010).
Synthetic biology is constantly making progress for producing compounds on demand.Recently,Yocum and collaborators have developed an outstanding approach based on the anchoring of biosynthetic enzymes to the peroxisom...
关键词：Synthetic biology Enzymes colocalization Peroxisomal membrane ACETYL-COA POLYKETIDES 
ezQTL:A Web Platform for Interactive Visualization and Colocalization of QTLs and GWAS Loci
《Genomics, Proteomics & Bioinformatics》2022年第3期541-548,共8页Tongwu Zhang Alyssa Klein Jian Sang Jiyeon Choi Kevin M.Brown 
the Intramural Research Program(Grant No.1ZIACP010201);the Division of Cancer Epidemiology and Genetics Informatics Tool Challenge of NCI.
Genome-wide association studies(GWAS)have identified thousands of genomic loci associated with complex diseases and traits,including cancer.The vast majority of common traitassociated variants identified via GWAS fall...
关键词：Genome-wide association study Expression quantitative trait locus COLOCALIZATION Linkage disequilibrium VISUALIZATION 
Colocalization of dopamine receptors in BDNF-expressing peptidergic neurons in the rat paraventricular nucleus
《解剖学杂志》2021年第S01期76-76,共1页Wang Zhiyong Zhou Li Zhang Yang Lian Hui Li Yong 
Brain derived neurotrophic factor(BDNF)in the paraventricular nucleus of the hypothalamus(PVN)can regulate food intake and energy expenditure.However,the regulatory mediator of BDNF positive neurons in the PVN remains...
关键词：DOPAMINE INTAKE HYPOTHALAMUS 
Advances and challenges in quantitative delineation of the genetic architecture of complex traits
《Quantitative Biology》2021年第2期168-184,共17页Hua Tang Zihuai He 
This work is supported by NIH R35GM127063(HT)and NIH AG066206(ZH).
Background:Genome-wide association studies(GWAS)have been widely adopted in studies of human complex traits and diseases.Results:This review surveys areas of active research:quantifying and partitioning trait heritabi...
关键词：genome-wide association study HERITABILITY rare variants BIOBANK COLOCALIZATION EQTL polygenic risk scores transcriptome-wide association study 
Enduring alterations in hippocampal astrocytesynaptic proximity following adolescent alcohol exposure: reversal by gabapentin被引量：1
《Neural Regeneration Research》2020年第8期1496-1501,共6页Kati L.Healey Sandra Kibble Sierra Hodges Kathryn J.Reissner Anze Testen Tiffany A.Wills Shawn K.Acheson Benjamin M.Siemsen John A.McFaddin Michael D.Scofield H.Scott Swartzwelder 
supported by the National Institute on Alcohol Abuse and Alcoholism(NIAAA)Neurobiology of Adolescent Drinking In Adulthood(NADIA)Grant#2U01AA019925(to HSS);the National Institute on Alcohol Abuse and Alcoholism(NIAAA)R00AA022651(to TAW);the National Institute on Drug Abuse(NIDA)R01DA041455(to KJR)
Adolescent alcohol abuse is a substantive public health problem that has been the subject of intensive study in recent years.Despite reports of a wide range of effects of adolescent intermittent ethanol(AIE)exposure o...
关键词：ADOLESCENT ALCOHOL ASTROCYTE astrocyte morphology astrocyte-neuronal colocalization CA1 GABAPENTIN GluA1 hippocampus tripartite synapse 
Role of Interleukin 17A in Aortic Valve Inflammation in Apolipoprotein E-deficient Mice被引量：1
《Current Medical Science》2020年第4期729-738,共10页Fa-yuan LIU Peng BAI Ye-fan JIANG Nian-guo DONG Geng LI Chong CHU 
This project was supported by grants from the National Key Research and Development Program of China(No.2016YFA0101100);National Natural Science Foundation of China(No.81700339 and No.31330029);Scientific Research Training Program for Young Talents sponsored by Union Hospital,Tongji Medical College,Huazhong University of Science and Technology。
Summary:Interleukin 17A(IL 17A)is reported to be involved in many inflammatory processes,but its role in aortic valve diseases remains unknown.We examined the role of IL17A based on an ApoE^-/-mouse model with strateg...
关键词：aortic valve inflammation interleukin 17A NF-kB pathway intensity correlation analysis COLOCALIZATION 
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