CODON

作品数：119被引量：255H指数：8
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相关机构：南京林业大学北京大学广西医科大学第一附属医院天津医科大学更多>>
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Strategic codon selection for enhanced genetic code expansion
《Science China(Life Sciences)》2025年第3期884-886,共3页Zhouqing Luo Junbiao Dai 
supported by the National Key Research and Development Program of China(2021YFF1200300);the National Natural Science Foundation of China(32122050,32370074);Guangdong Basic and Applied Basic Research Foundation(2021B1515020060);Guangdong Provincial Science and Technology Projects(2022A0505090009);Innovation Program of Chinese Academy of Agricultural Science,and Shenzhen Outstanding Talents Training Fund.
Incorporating noncanonical amino acids(ncAAs)beyond these naturally occurring ones into proteins has proven to be a powerful method for modifying their properties,leading to significant advancements in both fundamenta...
关键词：EXPANSION system FIGURE 
Trends in oxycodone and oxycodone-containing analgesics administration for back pain in emergency departments in the USA(2007–2018)
《World Journal of Emergency Medicine》2024年第3期169-174,共6页Jonathan Chabon Jemer Garrido Deanna Schreiber-Gregory Jefferson Drapkin Sergey Motov 
BACKGROUND:To describe trends in oxycodone and oxycodone-containing analgesic prescribing for the treatment of back pain among adults in emergency departments(EDs) in the USA from 2007 to 2018.METHODS:Data were gather...
关键词：OXYCODONE Back pain Emergency department 
罕见β-珠蛋白基因Codon 24(GGT>GGA)突变导致β-地中海贫血1例及文献分析
《广西医科大学学报》2024年第4期585-589,共5页梁文雪 陈成 李琦 陈萍 张学 
广西科技基地和人才专项项目(No.桂科AD23026025);国家自然科学基金资助项目(No.81960574)。
目的:分析罕见β-珠蛋白基因突变类型、血液学及临床特征。方法:收集疑为β-地中海贫血的病例120例。对病例进行全血细胞分类及计数、血红蛋白(Hb)电泳分析检测。用跨越断裂点PCR方法、荧光PCR熔解曲线方法、DNA测序等分析α-和β-珠蛋...
关键词：Β-地中海贫血 Codon 24(GGT>GGA) 基因突变 临床表型 
Bioorthogonal Engineered Virus‑Like Nanoparticles for Efficient Gene Therapy被引量：2
《Nano-Micro Letters》2023年第11期119-135,共17页Chun‑Jie Bao Jia‑Lun Duan Ying Xie Xin‑Ping Feng Wei Cui Song‑Yue Chen Pei‑Shan Li Yi‑Xuan Liu Jin‑Ling Wang Gui‑Ling Wang Wan‑Liang Lu 
supported by the National Natural Science Foundation of China(Grant No.81874303 and No.82173752 W.L.Lu).
Gene therapy offers potentially transformative strategies for major human diseases.However,one of the key challenges in gene therapy is developing an effective strategy that could deliver genes into the specific tissu...
关键词：Virus-like nanoparticle Site-specific codon mutation Recombinant biosome Bioorthogonal chemistry Gene therapy 
Different oncological features of colorectal cancer codon-specific KRAS mutations:Not codon 13 but codon 12 have prognostic value被引量：3
《World Journal of Gastroenterology》2023年第32期4883-4899,共17页Hong-Min Ahn Duck-Woo Kim Tae Gyun Lee Hye-Rim Shin In Jun Yang Jeehye Lee Jung Wook Suh Heung-Kwon Oh Sung-Bum Kang 
BACKGROUND Approximately 40%of colorectal cancer(CRC)cases are linked to Kirsten rat sarcoma viral oncogene homolog(KRAS)mutations.KRAS mutations are associated with poor CRC prognosis,especially KRAS codon 12 mutatio...
关键词：Genes Ras CODON Colonic neoplasms Rectal neoplasms 
Phylogeny,molecular evolution,and dating of divergences in Lagerstroemia using plastome sequences被引量：2
《Horticultural Plant Journal》2023年第2期345-355,共11页Jie Wang Wenchuang He Xuezhu Liao Jin Ma Wei Gao Haoqi Wang Dili Wu Luke R.Tembrock Zhiqiang Wu Cuihua Gu 
supported by the Zhejiang Provincial Natural Science Foundation of China(Grant No.LY21C160001);Zhejiang Provincial Key Laboratory of Germplasm Innovation and Utilization for Garden Plants.
Lagerstroemia L.(Lythraceae)is a widely distributed genus of trees and shrubs native to tropical and subtropical environments from Southeast Asia to Australia,with numerous species highly valued as ornamentals.Althoug...
关键词：Lagerstroemia L Evolutionary rate Single-nucleotide variants Molecular dating Chloroplast CODON Covarion 
Constitutive expression of codon optimized Trichoderma reesei TrCel5A in Pichia pastoris using GAP promoter
《Systems Microbiology and Biomanufacturing》2022年第3期498-506,共9页Yun Hu Renhui Bai Shaohua Dou Zhimeng Wu Ali Abdulkhani Mohammad Ali Asadollahi Abd El-Fatah Abomohra Fubao Sun 
supported by the National Key Research and Development Program of China(2019YFE0114600);National Natural Science Foundation of China(21776114).
To address the deficient activity of TrCel5A in naturally secreted cellulase preparation,this study used the GAP promoter to induce constitutive expression of Trichoderma reesei TrCel5A in Pichia pastoris.A recombinan...
关键词：Trichoderma reesei endoglucanase(Cel5A) Pichia pastoris GAP promoter Constitutive expression Fermentation optimization CMC enzyme activity 
Toward efficient multiple-site incorporation of unnatural amino acids using cell-free translation system
《Synthetic and Systems Biotechnology》2022年第1期522-532,共11页Jiaqi Hou Xinjie Chen Nan Jiang Yanan Wang Yi Cui Lianju Ma Ying Lin Yuan Lu 
the National Key R&D Program of China(Grant No.2018YFA0901700);the National Natural Science Foundation of China(Grant No.21878173);the Beijing Natural Science Foundation(Grant No.2192023).
Amber suppression has been widely used to incorporate unnatural amino acids(UNAAs)with unique structures or functional side-chain groups into specific sites of the target protein,which expands the scope of protein-cod...
关键词：Cell-free protein synthesis Orthogonal translation system Unnatural protein Unnatural amino acid Terminal codon suppression 
p53 codon 72基因多态性与中国女性乳腺癌发生风险关系的系统评价与Meta分析被引量：5
《医学新知》2022年第1期23-32,共10页徐文斌 龚乘丙 李尧 钟广鑫 沈翔 徐斌 蒋文龙 刘江波 
河南省医学科技攻关计划(201504009);河南科技大学2019年度大学生研究训练计划(2019340,2019343)。
目的探讨p53 codon 72基因多态性与中国女性乳腺癌发生风险的关系。方法计算机检索PubMed、Embase、Web of Science、中国知网、万方数据库,收集有关p53 codon 72基因多态性与乳腺癌发生风险的相关研究,检索时限为建库至2021年3月31日...
关键词：P53 基因多态性 乳腺癌 发生风险 META分析 
Codon Usage of Chloroplast Gene rbcL in Laurencia sensu lato(Rhodophyta)species
《Journal of Marine Science》2021年第4期1-16,共16页Ruben Cabrera Jhoana Díaz-Larrea Arsenio JAreces Laura Nuñez García JRicardo Cruz-Aviña Gabriela Vázquez Silva 
UAM-I-117“Macroalgas Marinas y Salobres”of the CBS-UAMI Division,and the Ministry of Science and Innovation of the Spanish Government(CGL2010-14881).
Recent advances in molecular biology make it possible to sequence not only genes or genomes,but also to understand codon dynamics.For the organelle genes of these organisms,a small set of preferred codons are used for...
关键词：CODON Laurencia sensu lato SYSTEMATICS RHODOPHYTA Marine algae 
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