SITE-DIRECTED

作品数：34被引量：31H指数：2
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Optical biosensing of monkeypox virus using novel recombinant silica-binding proteins for site-directed antibody immobilization
《Journal of Pharmaceutical Analysis》2024年第10期1496-1504,共9页Xixi Song Ying Tao Sumin Bian Mohamad Sawan 
This research was supported by Westlake University,China(Startup funds);the Research Center for Industries of the Future of Westlake University,China(Grant No.:WU2022C040);the National Natural Science Foundation of China(Grant No.:82104122).
The efficient immobilization of capture antibodies is crucial for timely pathogen detection during global pandemic outbreaks.Therefore,we proposed a silica-binding protein featuring core functional domains(cSP).It com...
关键词：Site-directed immobilization Silica-binding proteins Optical biosensing Monkeypox virus Spiked clinical samples Multi-virus biosensor 
Site-directed cysteine coupling of disulfide-containing non-antibody carrier proteins(THIOCAPs)
《Science China Materials》2023年第10期4109-4120,共12页Ariana Rueda Julian I.Mendoza Lorena Alba-Castellon Eloi Parladé Eric Voltà-Durán David Paez Anna Avino Ramon Eritja Esther Vázquez Antonio Villaverde Ramón Mangues Ugutz Unzueta 
to ISCIII(PI20/00400)cofunded by European Regional Development Fund(ERDF,a way to make Europe);to CIBER-BBN(project NANOSCAPE and NANOLINK)granted to Unzueta U;to AEI(PID2019-105416RB-I00/AEI/10.13039/501100011033);to CIBER-BBN(NANOREMOTE)granted to Vázquez E;to ISCIII(PI21/00150)co-funded by European Regional Development Fund(ERDF,a way to make Europe);to CIBER-BBN(4NanoMets);to AGAUR(2021 SGR-01140)granted to Mangues R;to CIBER-BBN(VENOM4CANCER);AGAUR(2021 SGR-00092)granted to Villaverde A;supported by CIBER-Consorcio Centro de Investigación Biomédica en Red-(CB06/01/1031 and CB06/01/0014);Instituto de Salud Carlos III,Ministerio de Ciencia e Innovación and European Regional Development Fund(ERDF);by CERCA programme(Generalitat de Catalunya);supported by Miguel Servet contract(CP19/00028)from ISCIII co-funded by European Social Fund(ESF investing in your future);supported by the Spanish Association Against Cancer-AECC(POSTD20070ALBA);supported by a PFIS predoctoral fellowship(FI21/00012)from ISCIII co-funded by European Social Fund(ESF,investing in your future)and EVD by a predoctoral fellowship from Ministerio de Ciencia,Innovación y Universidades(FPU18/04615);support from the National Institutes of Health R01-GM129325;the Office of Cyber Infrastructure and Computational Biology,National Institute of Allergy and Infectious Diseases。
The development of a new generation of nonantibody protein drug delivery systems requires site-directed conjugation strategies to produce homogeneous,reproducible and scalable nanomedicines.For that,the genetic additi...
关键词：DISULFIDE directed BRIDGES 
Site-directed deuteration of dronedarone preserves cytochrome P4502J2 activity and mitigates its cardiac adverse effects in canine arrhythmic hearts被引量：2
《Acta Pharmaceutica Sinica B》2022年第10期3905-3923,共19页Aneesh V.Karkhanis Gopalakrishnan Venkatesan Ryuichi Kambayashi Jacqueline Wen Hui Leow Marcus Qingrui Han Hiroko Izumi-Nakaseko Ai Goto Jeremy Kah Sheng Pang Boon Seng Soh Pipin Kojodjojo Atsushi Sugiyama Eric Chun Yong Chan 
supported by the National University Heart Centre Singapore (NUHCS) Cardiovascular Research Institute (CVRI)Core Fund [Grant NUHSRO/2019/082/Core];SCEPTRE CG Seed Grant [Grant NMRC/CG/M008/2017, Singapore];Singapore Ministry of Education Tier 1 Academic Research Funding [Grant R-148-000-193-112];the National University of Singapore, Department of Pharmacy, Final Year Project Funding [Grant C148-000-003-001] provided to Eric Chun Yong Chan;from Japan Society for the Promotion of Science (JSPS) KAKENHI [grant number 20K16136] provided to Ryuichi Kambayashi
Cytochrome P4502J2(CYP2J2)metabolizes arachidonic acid(AA)to cardioprotective epoxyeicosatrienoic acids(EETs).Dronedarone,an antiarrhythmic drug prescribed for treatment of atrial fibrillation(AF)induces cardiac adver...
关键词：Arachidonic acid Atrial fibrillation CYP2J2 Drug-induced proarrhythmia Epoxyeicosatrienoic acids Mechanism-based inactivation DRONEDARONE 
Protection-Free Site-Directed Peptide or Protein S-Glycosylation and Its Application in the Glycosylation of Glucagon-like Peptide 1被引量：2
《CCS Chemistry》2022年第6期1930-1937,共8页Gefei Li Yuankun Dao Juan Mo Suwei Dong Shin-ichiro Shoda Xin-Shan Ye 
financially supported by grants from the National Natural Science Foundation of China(nos.21907004 and 81821004);the National Key R&D Program of China(no.2018YFA0507602);the Beijing Outstanding Young Scientist Program(no.BJJWZYJH01201910001001).
The development of a facile cysteine-directed S-glycosylation strategy would facilitate the intensive investigation of the effect of glycosylation on protein translational modification.Herein,we introduce glycosyl Bun...
关键词：site-selective S-glycosylation peptide/protein-modification glycosyl Bunte salt disulfide bond GLP-1 
Uncarialins J-M from Uncaria rhynchophylla and Their Anti-depression Mechanism in Unpredictable Chronic Mild Stress-Induced Mice via Activating 5-HT_(1A) Receptor被引量：2
《Chinese Journal of Chemistry》2021年第5期1331-1343,共13页Zhen-Long Yu Rong Bai Jun-Jun Zhou Hui-Lian Huang Wen-Yu Zhao Xiao-Kui Huo Ya-Hui Yang Zhi-Lin Luan Bao-Jing Zhang Cheng-Peng Sun Xiao-Chi Ma 
the Dalian Science and Technology Leading Talents Project(No.2019RD15);the Distinguished Professor of Liaoning Province,the Open Research Fund of the State Key Laboratory of Cognitive Neuroscience and Learning(No.CNLZD1801);the Natural Science Foundation of Liaoning Province(No.2020-MS-256);the Dalian Young Star of Science and Technology(No.2019RQ123);the Shanghai"Rising Stars of Medical Talent" Youth Development Program-Youth Medical Talents-Clinical Pharmacist Program(No.SHWJRS(2019)_072).
Uncaria rhynchophylla has been widely used to treat central nervous system diseases for a long history.After investigation of U.rhynchophylla,eleven monoterpene indole alkaloids,including four new compounds uncarialin...
关键词：Monoterpene indole alkaloids Hirsuteine DEPRESSION 5-HT_(1A)receptor Site-directed amino acid mutation 
Using multiple site-directed modification of epoxide hydrolase to significantly improve its enantioselectivity in hydrolysis of rac-glycidyl phenyl ether
《Chinese Journal of Chemical Engineering》2020年第8期2181-2189,共9页Yao Li Xiaoyang Ou Zewang Guo Minhua Zong Wenyong Lou 
the National Natural Science Foundation of China(21676104,21878105,21908070);the National Key Research and Development Program of China(2018YFC1603400,2018YFC1602100);the Key Research and Development Program of Guangdong Province(2019B020213001);the Science and Technology Program of Guangzhou(201904010360);the Fundamental Research Funds for the Central Universities(2019PY15,2019MS100);the China Postdoctoral Science Foundation(BX20180102)for partially funding this work。
The epoxide hydrolase gene(SpEH) from Sphingomonas sp. HXN-200 was synthesized and expressed in robust Escherichia coli cells that had a dual protection system. The enantioselectivity(E-value) of the recombinant SpEH ...
关键词：Epoxide hydrolase Phenyl glycidyl ether ENANTIOSELECTIVITY Directed modification 
An Assessment of the Surgical Results of the Site-Directed Surgical Treatment in Obstructive Sleep Apnoea Syndrome被引量：1
《International Journal of Otolaryngology and Head & Neck Surgery》2020年第4期111-123,共13页D. R. Kandel A. Thakar S. C. Sharma S. K. Sharma A. Trikha G. Shukla A. S. Bhalla R. Kumar R. C. Deka 
Background: Obstructive sleep apnea (OSA) has cardiovascular, neurological, and social complications. Surgical treatment has the potential to improve airway patency b...
关键词：Obstructive Sleep Apnoea POLYSOMNOGRAPHY Retroglossal Apnoea Hypopnoea Index 
Site-directed RNA editing(SDRE):Off-target effects and their countermeasures
《Journal of Genetics and Genomics》2019年第11期531-535,共5页Shaoshuai Mao Yajing Liu Shisheng Huang Xingxu Huang Tian Chi 
supported by the start-up package of the ShanghaiTech University.
Site-directed RNA editing(SDRE)is invaluable to basic research and clinical applications and has emerged as a new frontier in genome editing.The past few years have witnessed a surge of interest in SDRE,with SDRE tool...
关键词：Gene EDITING RNA EDITING Cas13 Off-target SPECIFICITY 
Identification of Residue Involved in Nucleotidyltransferase Activity of LinA from Staphylococci by Site-directed Mutagenesis
《Chinese Journal of Structural Chemistry》2019年第3期422-428,共7页ZOU Xiao-Ming JIANG Mei-Qin ZHAO Yan-He SUN Li-Fang YANG Wen-Di YE Xian-Ren WU Yun-Kun 
supported by the National Natural Science Foundation of China(31470741);Natural Science Foundation of Fujian Province(2016J01173);the Key Project of Fujian Province(2017N0031);the STS project of Chinese Academy of Sciences and Fujian Province(2016T3041);the medical talent training project of Fujian provincial health and family planning commission(2016-ZQN-19);National Thousand Talents Program of China
The lincosamide class of antibacterials is widely used for the treatment of a broad spectrum of infections, and one prevalent route of resistance to lincosamides in pathogenic gram-positive cocco is antibiotic modific...
关键词：LinA nucleotidyltransferase SITE-DIRECTED MUTAGENESIS ENZYMATIC assay ITC 
TALEN-Mediated Homologous Recombination Produces Site-Directed DNA Base Change and Herbicide-Resistant Rice被引量：16
《Journal of Genetics and Genomics》2016年第5期297-305,共9页Ting Li Bo Liu Chih Ying Chen Bing Yang 
provided by the grant(2013-33522-21091 to B.Y.) from the USDA Biotechnology Risk Assessment program
Over the last decades,much endeavor has been made to advance genome editing technology due to its promising role in both basic and synthetic biology.The breakthrough has been made in recent years with the advent of se...
关键词：TALEN Genome editing Homologous recombination Gene replacement Site-directed mutagenesis Acetolactate synthase Herbicide resistance Rice 
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