POLYPEPTIDE

作品数：239被引量：460H指数：9
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A GSH-Responsive Immune-Stimulating Polypeptide Hydrogel Loaded with Chemotherapeutics,IDO Inhibitor and Immune Checkpoint Blocking Antibody for Enhanced Anti-Tumor Chemo-Immunotherapy
《Chinese Journal of Chemistry》2024年第23期2957-2969,共13页Junfeng Ding Tianran Wang Yan Rong Chaoliang He Xuesi Chen 
financially supported by the National Natural Science Foundation of China(Projects 52173147,52203202,51973218);the Scientific and Technological Development Projects of Jilin Province(20240202002GX).
Due to the immunosuppressive tumor microenvironment(TME),T cells are usually inactivated and tend to differentiate into regulatory T cells(Tregs)in the tumor tissues,which seriously hinders the anti-tumor efficiency o...
关键词：Immune-stimulating hydrogel POLYPEPTIDE Stimuli-responsive Immunotherapy Immunosuppressive microenvironment Cancertreatment Drug delivery 
Reduced Macrophage Uptake of Nanoparticles through Surface Modification of Polypeptides with Valine Residues被引量：1
《Chinese Journal of Chemistry》2024年第11期1209-1216,共8页Ning Li Shanshan Xiao Xiaoxiong Jin Ziyuan Song 
supported by the National Natural Science Foundation of China(22101194);Natural Science Foundation of Jiangsu Province(BK20210733);Suzhou Municipal Science and Technology Bureau(ZXL2021447)。
The structural and surface properties of nanomedicines play an important role in determining their biological fate. Surface chemistry of nanomedicines is one of the key parameters, where researchers used various strat...
关键词：NANOPARTICLES Copolymers Structure-activity relationships Surface chemistry POLYPEPTIDE Macrophage uptake 
Accelerated Ring-Opening Polymerization of α-Amino Acid N-Carboxyanhydride via Inorganic Nano-initiators被引量：1
《Chinese Journal of Chemistry》2023年第19期2476-2482,共7页Junliang Zhu Yunjie He Chenglong Ge Wenting Si Ziyuan Song Lichen Yin 
supported by the National Natural Science Foundation of China(22101194 and 52273144);Science and Technology Department of Jiangsu Province(BK20210733).
While the accelerated polymerization of N-carboxyanhydrides (NCAs) has been utilized to synthesize versatile polypeptide materials in an efficient manner with minimized side reactions, the preparation of polypeptide-b...
关键词：POLYPEPTIDE N-CARBOXYANHYDRIDE INORGANIC organic nano-hybrids Cooperative covalent polymerization Ring-opening polymerization Kinetics Synthetic methods 
Nitric Oxide-Releasing Poly(L-glutamic acid)Hybrid Hydrogels for Accelerating Diabetic Wound Healing被引量：2
《Chinese Journal of Chemistry》2023年第17期2103-2112,共10页Lin Teng Yingying Song Lingli Hu Qian Bai Xueliang Zhang Chang-Ming Dong 
financial support by National Natural Science Foundation of China(22075176);Natural Science Foundation of Shanghai(22ZR1429200).
Comprehensive Summary,Diabetic wound healing is threatening worldwide and challenging in wound dressings.Aiming to inhibit heavy inflammation and bacterial infection in diabetic wounds,herein,we facilely construct a k...
关键词：POLYPEPTIDE Hydrogel Nitric oxide Diabetic wound Wound healing Wound dressings 
Stimuli-Responsive Polypeptide-Based Supramolecular Hydrogels Mediated by Ca^2+ Ion Cross-Linking被引量：5
《Chinese Journal of Chemistry》2019年第11期1137-1141,共5页Fandong Meng Jing Sun Zhibo Li 
This work was supported by the National Basic Research Pro­gram of China(Nos.2015CB931900,2012CB215500);the National Natural Science Foundation of China(Nos.21632009,21421002);the Key Program of the Chinese Academy of Sciences(No.KGZD-EW-T08);the Key Research Program of Frontier Sciences of CAS(No.QYZDJ-SSWSLH049);the Shanghai Rising-Star Program(No.16QA1404600)for financial support.
Background and Originality Content Hydrogels,which retain a large amount of water,possess tunable porous three-dimensional nanostructure.They are known to resemble human tissue that can offer many advantages in biomed...
关键词：HYDROGEL CRITICAL POROUS 
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