PRECORE

作品数：21被引量：182H指数：8
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相关领域：医药卫生更多>>
相关作者：谢英陈冠州吴贻琛万志红张爱民更多>>
相关机构：北京协和医学院台湾大学河北医科大学解放军第302医院更多>>
相关期刊：《Virologica Sinica》《World Journal of Gastroenterology》《World Journal of Hepatology》《Journal of Hainan Medical University》更多>>
相关基金：国家自然科学基金安徽省自然科学基金广东省自然科学基金北京市自然科学基金更多>>
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Precore mutation enhances viral replication to facilitate persistent infection especially in HBeAg-negative patients被引量：1
《Virologica Sinica》2024年第2期319-330,共12页Guixin Li Danli Yang Xin Liu Ting Zhang Hui Liu Jun Zou Zimeng Xu Xiangmei Chen Lizhong Dai Hongsong Chen Fengmin Lu 
supported by National Key R&D Program of China(2023YFC2306800);National Natural Science Foundation of China(No.82072280 and No.82272315);Beijing Municipal Natural Science Foundation(No.7212063 and No.7222108).
Naturally occurred precore(PC,G1896A)and/or basal core promoter(BCP,A1762T/G1764A)mutations are prevalent in chronic HBV-infected patients,especially those under HBeAg-negative status.However,the replicative capacity ...
关键词：Hepatitis B virus Precore mutation Basal core promoter mutations Endoplasmic reticulum stress 
HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathway被引量：2
《Virologica Sinica》2023年第5期680-689,共10页Baoxin Zhao Hongxiu Qiao Yan Zhao Zhiyun Gao Weijie Wang Yan Cui Jian Li Zhanjun Guo Xia Chuai Sandra Chiu 
This work was supported by the S&T Program of Hebei(20372601D);the Natural Science Foundation of Hebei Province,China(H2020206352,C2021206004);the Science and Technology Project of Hebei Education Department(QN2018150,QN2020268),Hebei Medical Science Research Project(20220973);Chinese Medicine Research Program of Hebei Province(2021119).
Chronic hepatitis B virus(HBV)infection is one of the leading causes of hepatocellular carcinoma(HCC).The HBV genome is prone to mutate and several variants are closely related to the malignant transformation of liver...
关键词：HBV G1896A mutation Hepatocellular carcinoma(HCC) Proliferation Apoptosis ERK/MAPK 
Systematic evaluation of HBV BCP/PC mutations on the risk of hepatocarcinogenesis
《Journal of Hainan Medical University》2023年第8期49-59,共11页FU Wei HUANG Sheng‑kai SUN Long 
Hainan Natural Science Foundation Project(No.819MS122);Hainan Provincial Department of Education Fund Project(No.hnky 2017‑38)。
Objective:To evaluate of the effects of mutations in BCP-A1762T/G1764A and PC-G1896A genes on hepatocarcinogenesis.Methods:Computer searches for PubMed,SCI,CNKI,VIP and WanFang Data databases were conducted to collect...
关键词：NHepatitis B virus MUTATION Basal core promoter PRECORE Hepatocellular carcinoma 
Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severity被引量：5
《World Journal of Hepatology》2022年第4期708-718,共11页Rajesh Kumar 
Of 350 million people worldwide are chronically infected with hepatitis B virus(HBV)and are at risk of developing cirrhosis and hepatocellular carcinoma(HCC)later in life.HBV is the most diverse DNA virus,and its geno...
关键词：Hepatitis B virus Hepatitis B virus e antigen Hepatocellular carcinoma Basal core promoter Core promoter region Precore region Fulminant hepatitis Acute hepatitis 
Conservative Evolution of Hepatitis B Virus Precore and Core Gene During Immune Tolerant Phase in Intrafamilial Transmission被引量：1
《Virologica Sinica》2020年第4期388-397,共10页Yuqian Luo Le Zhang Yimin Dai Yali Hu Biyun Xu Yi-Hua Zhou 
supported by the National Natural Science Foundation of China(81672002);the Science and Technology Department of Jiangsu Province(BK20161105);the Jiangsu Provincial Department of Health(H201537),China。
Hepatitis B virus(HBV)is characterized with high mutations,which is attributed to the lack of proof-reading of the viral reverse transcriptase and host immune pressure.In this study,31 HBV chronic carriers from 14 fam...
关键词：Hepatitis B virus(HBV) Pre-C/C gene Sequence evolution 
Precore/core region mutations of hepatitis B virus related to clinical severity被引量：10
《World Journal of Gastroenterology》2016年第17期4287-4296,共10页Hong Kim Seoung-Ae Lee Seung Yeon Do Bum-Joon Kim 
Supported by A National Research Foundation grant of Ministry of Science, ICT and Future Planning, South Korea, No. NRF-2015R1C1A1A02037267;a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, the Ministry of Health and Welfare, South Korea, No. HI14C0955
Despite the availability of an effective vaccine, hepatitis B virus (HBV) infection remains a major health problem, with more than 350 million chronically infected people worldwide and over 1 million annual deaths due...
关键词：Hepatitis B virus infection Precore/core mutations Hepatocellular carcinoma HBeAg serostatus Disease severity 
Precore/basal core promoter mutants quantification throughout phases of hepatitis B virus infection by Simpleprobe被引量：8
《World Journal of Gastroenterology》2015年第21期6639-6648,共10页Wen-Hui Tu Ying Lv Yong-Mei Zhang Wei Hou Jin-Yu Wang Yi-Jun Zhang Hong-Yan Liu Hao-Xiang Zhu Yan-Li Qin Ri-Cheng Mao Ji-Ming Zhang 
Supported by National Science and Technology Major Project of China,No.2012ZX10002007-001-002 and No.2013ZX10002001(to Zhang JM);the National Natural Science Foundation of China,No.81271833 and No.81471933(to Zhang JM);the Science and Technology Plan Project of Taizhou,Zhejiang province,No.1402ky19(to Tu WH and Hou W);the Scientific Research Project of Taizhou University,Zhejiang province,No:2014PY054(to Tu WH and Hou W)
AIM:To investigate precore/basal core promoter(PC/BCP) mutants throughout hepatitis B virus(HBV) infection and to determine their relationship to hepatitis B early antigen(HBeA g) titers.METHODS:We enrolled 191 patien...
关键词：PRECORE mutant BASAL core promotermutant HEPATITIS B virus Quantification HEPATITIS Bearly ANTIGEN titers 
HBeAg negative variants and their role in the natural history of chronic hepatitis B virus infection被引量：24
《World Journal of Gastroenterology》2014年第24期7644-7652,共9页Alexra Alexopoulou Peter Karayiannis 
Molecular virology methods including polymerase chain reaction, cloning and sequencing have revolutionised our understanding of viral genome variation. In the case of hepatitis B virus (HBV), sequencing studies have i...
关键词：Precore stop codon variants basal core promoter variants hepatitis B e antigen negative chronic hepatitis B Re-activation Hepatitis B virus-DNA replication 
The relationship between the hepatitis B virus base core and precore/core promoter mutations and the development of cirrhotic hepatocellular carcinoma and noncirrhotic hepatocellular carcinoma
《China Medical Abstracts(Internal Medicine)》2013年第1期13-13,共1页徐尧江 
Objective To investigate the mutations of basal core promoter(BCP) and precore(PreC) region of hepatitis B virus(HBV) and the association with the development of hepatocellular carcinoma in patients with chronic HBV i...
关键词：cirrhotic promoter UNTREATED BASAL independently mutation GENOTYPE sequencing 
Characterization of hepatitis B virus genotypes/subgenotypes in 1301 patients with chronic hepatitis B in North China被引量：26
《Chinese Medical Journal》2011年第24期4178-4183,共6页LI Xiao-dong WANG Lin LIU Yan XU Zhi-hui DAI Jiu-zeng LI Le YAO Zeng-tao XIN Shao-jie XU Dong-ping ZHAO Jing-ming 
This work was supported by the grants from the Beijing Natural Science Foundation （No. 7091006）, the National Key Basic Research Developing Project （No. 2007CB512803）, and the National 11th Five-Year Special Grand Project for Infectious Diseases （No. 2008ZX10002-011 and No. 2009ZX10004-314）. Conflict of interests： None.
Background There is still a paucity of data on hepatitis B virus （HBV） subgenotype prevalence in North China based on sequencing of large-size samples. In addition, whether HBV genotypes impact drug-resistance-assoc...
关键词：hepatitis B virus GENOTYPE drug resistance PRECORE basal core promoter mutation 
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