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Supported by the National Natural Science Foundation of China(No.42176101);the Ningbo Youth Science and Technology Innovation Leading Project(No.2024QL063);the National 111 Project of China(No.D16013);the Scientific Research Fund of Zhejiang Provincial Education Department(No.Y202250186);the Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Development Fund。
Marine natural products offer a promising source in the development of new antibiotic drugs.Two previously undescribed compounds,including one sulfur-bearing alkaloid named quinosumycin(1)along with one chromone deriv...
from the equipment and framework of the COMP-HUB Initiative,funded by the“Departments of Excellence"program of the Italian Ministry for Education,University and Research(MIUR,2018-2022);"ECOSISTER"funded under the National Recovery and Resilience Plan(NRRP),Mission 04 Component 2 Investment 1.5-NextGenerationEU(Call for tender n.3277,30/12/2021;Award Number 0001052,dated 23/06/2022).
A highly selective palladium-catalyzed carbonylation of 2-alkynylanilines bearing an amide moiety to condensed six-membered heterocyclic structures has been developed under mild conditions(room temperature and atmosph...
3-(5-(2.4-dichlorophyenyl)-4.5-dihydro-1H-pyrazol-3-yl)-4hydroxy-1-methylquinolin(1H)-one, 5-((4-hydroxy-8-methyl-2-oxo-1.2-dihydroquinolin-3-yl)methylene)-1-phenyl-2-hioxodihydropyrimidine-4.6(1H.5H)-dione, and 1-but...
To discover novel lead compounds with better antifungal activities, a series of novel strobilurin derivatives containing quinolin-2(1H)-one moiety was designed and synthesized via intermediate derivatization method....
SARS CoV 3CL^pro is known to be a promising target for development of therapeutic agents against the severe acute respiratory syndrome (SARS). A quinolinone compound 1 was selected via virtual screening, and it was ...
Quinolinone and its derivatives have been known as growth hormones, antibiotics, fragrance, fluorescent materials, etc. Although various photochemical behavior including photodimerization, photocycloaddition and photo...