PRODRUG

作品数：209被引量：333H指数：7
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相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>
相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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GSH-responsive camptothecin prodrug-based hybrid micellar nanoparticles enable antitumor chemo-immunotherapy by PD-L1 knockdown被引量：1
《Nano Research》2023年第1期834-848,共15页Xi Tan Hong Zhou Chenhui Wang Xuhan Liu Xiangliang Yang Wei Liu 
The authors acknowledge the support by the National Basic Research Program of China(Nos.2020YFA0710700 and 2018YFA0208900);the National Natural Science Foundation of China(No.31470968).
The combinational chemo-immunotherapy as a novel treatment strategy has been widely studied and applied in clinic to enhance antitumor therapeutic efficacy and relieve side effects.RNA interference(RNAi)targeting PD-L...
关键词：camptothecin prodrug hybrid micellar nanoparticles glutathione(GSH)-responsive PD-L1 knockdown chemoimmunotherapy 
A ROS-Stimulus-Responsive Nanocarrier Loading with Guanidine-Modified Hydroxycamptothecin Prodrug for Enhanced Anti-Tumor Efficacy被引量：2
《CCS Chemistry》2020年第5期305-316,共12页Zhilin Liu Haiyang Yu Na Shen Zhaohui Tang Xuesi Chen 
support for this work was provided by the Ministry of Science and Technology of China(no.2018ZX09711003-012);National Natural Science Foundation of China(Project nos.51503202,51673189,51873206,51833010,and 51520105004).
We report a reactive oxygen species(ROS)-stimulus-responsive phenylboronic acid pinacol ester nanocarrier,loaded with guanidine-modified 10-hydroxycamptothecin(HCPT)prodrug,to create a drug delivery-base nanomedicine....
关键词：ROS NANOMEDICINE cancer therapy PRODRUG NANOCARRIER 
A novel o-nitrobenzyl-based photocleavable antitumor prodrug with the capability of releasing 5-fluorourail被引量：2
《Science Bulletin》2016年第6期459-467,共9页Shuli Mo Ying Wen Fengfeng Xue Haichuang Lan Yueyuan Mao Guanglei Lv Tao Yi 
supported by the National Basic Research Program of China (2013CB733700);the China National Funds for Distinguished Young Scholars (21125104);the National Natural Science Foundation of China (51373039);Specialized Research Fund for the Doctoral Program of Higher Education (20120071130008)
An o-nitrobenzyl-based photocleavable antitumor prodrug with a terminal carboxyl group was designed and synthesized.The photolysis properties of the prodrug were investigated by means of1H NMR,HPLC,UV,and MTT methods....
关键词：Antitumor prodrug 5-Fluorourail Photocleavable o-Nitrobenzyl 
Synthesis and Anti-HIV Activity of a Series of 6-Modified 2＇,3＇-Dideoxyguanosine and 2＇,3＇-Didehydro-2＇,3＇- dideoxyguanosine Analogs被引量：2
《Chinese Journal of Chemistry》2013年第9期1207-1218,共12页Lujia Xie Xiantao Yang Delin Pan Yingli Cao Mou Cao Guichun Lin Zhu Guan Ying Guo Lihe Zhang Zhenjun Yang 
The research was supported by the fund of the National Natural Science Foundation of China，the Ministry of Science and Technology of China (No.2008ZX10303).Anti-HIV activity evaluation in pseudotyped HIV system was performed by Institute of Materia Medica,Chinese Academy of Medical Science and Peking Union Medical College.Anti-HIV activity evaluation in HIV-1/MT2 cells was performed by HD
In search of potential 2＇,3＇-dideoxyguanosine （ddG） and 2＇,3＇-didehydro-2＇,3＇-dideoxyguanosine （D4G） prodrugs, a series of 6-modified ddG, D4G analogs were synthesized and evaluated for their anti-HIV activi...
关键词：2＇ 3＇-dideoxyguanosine （ddG） 2＇ 3＇-didehydro-2＇ 3＇-dideoxyguanosine （D4G） PRODRUG anti-HIV activity 
Preparation, Characterization and in vitro Release of Chitosan-stavudine Conjugate Nano-prodrug被引量：1
《Journal of Wuhan University of Technology(Materials Science)》2013年第3期617-621,共5页曾戎 WANG Zehu WANG Hongran CHEN Liqiang 乔仁忠 HU Liming LI Zelin 
Funded by the National Natural Science Foundation of China(Nos.20504018,20972014,20604010,20872010 and 20732004);the National Basic Research Program of China(No.2009CB930203)
Chitosan-stavudine （d4T） conjugate with a succinic spacer was synthesized via carbodiimide coupling reaction and structurally characterized. In order to nanosize it for improving its therapeutic properties, the chit...
关键词：CHITOSAN STAVUDINE nano-prodrug polymeric conjugate 
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