PRODRUG

作品数：209被引量：333H指数：7
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相关作者：张礼和杨振军赵玉芬陈益崔永梅更多>>
相关机构：北京大学上海大学信息技术有限公司郑州大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划湖北省自然科学基金更多>>
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ROS-responsive nanoparticle delivery of ferroptosis inhibitor prodrug to facilitate mesenchymal stem cell-mediated spinal cord injury repair被引量：1
《Bioactive Materials》2024年第8期438-454,共17页Renshuai Hua Chenxi Zhao Zhengyu Xu Derong Liu Wenyuan Shen Wenlu Yuan Yan Li Jun Ma Zhishuo Wang Shiqing Feng 
supported by the National Key Research and Development Project of Stem Cell and Transformation Research(2019YFA0112100);Tianjin Key Medical Discipline(Specialty)Construct Project(TJYXZDXK-027A);International Innovation Summit for Academicians and Experts(22JRRCRC00010).We thank the Large Instrument Sharing Platform of Tianjin Medical University for the availability of the instruments.
Spinal cord injury(SCI)is a traumatic condition that results in impaired motor and sensory function.Ferroptosis is one of the main causes of neural cell death and loss of neurological function in the spinal cord,and f...
关键词：Spinal cord injury Huc-MSCs ROS-Responsive nanoparticles Ferroptosis inhibitor 
H_(2)O_(2)-responsive polymer prodrug nanoparticles with glutathione scavenger for enhanced chemo-photodynamic synergistic cancer therapy
《Bioactive Materials》2023年第7期189-200,共12页Guanchun Wang Yue Su Xinliang Chen Yongfeng Zhou Ping Huang Wei Huang Deyue Yan 
This work is supported by the National Natural Science Foundation of China(No.22275122,No.21702097,No.21875134No.52273281);the China Postdoctoral Science Foundation(No.2020M671096);the Medical Engineering Cross Project of Shanghai Jiao Tong University(No.YG2019ZDA05).
The combination of chemotherapy and photodynamic therapy(PDT)based on nanoparticles(NPs)has been extensively developed to improve the therapeutic effect and decrease the systemic toxicity of current treatments.However...
关键词：H_(2)O_(2)-responsiveness Alternating copolymer prodrug GSH-scavenger Photosensitizer Chemo-photodynamic synergistic cancer therapy 
Pt(Ⅳ) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy被引量：1
《Bioactive Materials》2023年第6期185-196,共12页Qingfei Zhang Xiaocheng Wang Gaizhen Kuang Yuanjin Zhao 
supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(52103196 and 52073060);Guangdong Basic and Applied Basic Research Foundation(2021B1515120054);the Shenzhen Fundamental Research Program(JCYJ20190813152616459 and JCYJ20210324133214038).
Multimodal treatment modalities hold great potential for cancer therapy,thus current efforts are focusing on the development of more effective and practical synergistic therapeutic platforms.Herein,we present a novel ...
关键词：MICROFLUIDICS Hydrogel microparticle Chemotherapy PHOTOTHERMAL Photodynamic Cancer therapy 
Macrophage membrane-biomimetic adhesive polycaprolactone nanocamptothecin for improving cancer-targeting efficiency and impairing metastasis被引量：6
《Bioactive Materials》2023年第2期449-462,共14页Kangkang Ying Yifeng Zhu Jianqin Wan Chenyue Zhan Yuchen Wang Binbin Xie Peirong Xu Hongming Pan Hangxiang Wang 
supported by grants from Zhejiang Provincial Natural Science Foundation of China(LR19H160002);National Natural Science Foundation of China(82073296 and 81773193);Research Project of Jinan Microecological Biomedicine Shandong Laboratory(JNL-2022010B).
The recent remarkable success and safety of mRNA lipid nanoparticle technology for producing severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines has stimulated intensive efforts to expand nanoparticle ...
关键词：Polymer prodrug Macrophage membrane Cancer nanomedicine Antimetastasis Nanocamptothecin 
Intelligent polymeric hydrogen sulfide delivery systems for therapeutic applications
《Bioactive Materials》2023年第1期198-216,共19页Fan Rong Tengjiao Wang Qian Zhou Haowei Peng Jingtian Yang Quli Fan Peng Li 
supports from National Natural Science Foundation of China(52003224,52073230);Natural Science Basic Research Program of Shaanxi Province(2020GXLH-Z-013,2019JQ-157);Natural Science Foundation of Ningbo(202003N4051).
Hydrogen sulfide(H_(2)S)plays an important role in regulating various pathological processes such as protecting mammalian cell from harmful injuries,promoting tissue regeneration,and regulating the process of various ...
关键词：Hydrogen sulfide prodrug Smart drug delivery Gas therapy Reactive sulfur species Precision medicine 
Formulation of pH-responsive PEGylated nanoparticles with high drug loading capacity and programmable drug release for enhanced antibacterial activity被引量：1
《Bioactive Materials》2022年第10期47-56,共10页Dawei Li Guoke Tang Hui Yao Yuqi Zhu Changgui Shi Qiang Fu Fei Yang Xing Wang 
supported by Youth Innovation Promotion Association CAS(2019031);National Natural Science Foundation of China(51973226,81972081 and 21604093);China Postdoctoral Science Foundation(2020M683733);Military Medical Science and Technology Youth Cultivation Project(20QNPY109);Military Medical Youth Growth Program of PLA General Hospital(QNC19028);Shanghai Changning Committee of Science and Technology of China(CNKW2020Y01).
In the current global crisis of antibiotic resistance,delivery systems are emerging to combat resistant bacteria in a more efficient manner.Despite the significant advances of antibiotic nanocarriers,many challenges l...
关键词：pH-responsive prodrug PEGylated Programmable drug release Schiff base Antibacterial activity 
2D-ultrathin MXene/DOXjade platform for iron chelation chemo-photothermal therapy被引量：5
《Bioactive Materials》2022年第8期76-85,共10页Yunjie Xu Yingwei Wang Jusung An Adam C.Sedgwick Mingle Li Jianlei Xie Weibin Hu Jianlong Kang Sajal Sen Axel Steinbrueck Bin Zhang Lijun Qiao Swelm Wageh Jonathan F.Arambula Liping Liu Han Zhang Jonathan L.Sessler Jong Seung Kim 
supported by the National Natural Science Foundation of China(Grant No.11904239,Y.W.W);the Creative Research Initiative of National Research Foundation of Korea(NRF)(CRI project No.2018R1A3B1052702,J.S.K.);Initial support for the work in Austin came from the National Institutes of Health(CA 68682 to J.L.S.)with subsequent funding from the Robert A.Welch Foundation(F-0018 to J.L.S.);supported by Brain Pool Program through the funded by the Ministry of Science and ICT(Grant No.2020H1D3A1A02080172,M.L.).
An increased demand for iron is a hallmark of cancer cells and is thought necessary to promote high cell proliferation,tumor progression and metastasis.This makes iron metabolism an attractive therapeutic target.Unfor...
关键词：2D MXene NANOMEDICINE PRODRUG Iron chelation Photothermal therapy 
Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy
《Bioactive Materials》2021年第10期3300-3313,共14页Jimin Zhang Meigui Deng Xiaoguang Shi Chuangnian Zhang Xiongwei Qu Xiuli Hu Weiwei Wang Deling Kong Pingsheng Huang 
We acknowledge the financial support from the National Natural Science Foundation of China(No.U20A20260,51973213);Natural Science Foundation of Hebei Province(C20202006)。
1.Introduction Chemotherapy is the traditional treatment for clinical cancer patient[1,2].However,the therapeutic effect is often severely limited by the multidrug resistance(MDR)[3,4],which was commonly mediated by i...
关键词：NO prodrug Supramolecular hydrogel Oxidative stress Multidrug resistance Synergistic therapy 
Cylindrical polymer brushes-anisotropic unimolecular micelle drug delivery system for enhancing the effectiveness of chemotherapy被引量：3
《Bioactive Materials》2021年第9期2894-2904,共11页Shuang Bai Die Jia Xianbin Ma Mengyun Liang Peng Xue Yuejun Kang Zhigang Xu 
This work was financially supported by National Natural Science Foundation of China(51703187,31671037);the Basic and Frontier Research Project of Chongqing(cstc2018jcyjAX0104).
Polymer systems can be designed into different structures and morphologies according to their physical and chemical performance requirements,and are considered as one of the most promising controlled delivery systems ...
关键词：Cylindrical polymer brushes Unimolecular micelles PRODRUG Reduction-responsive Cancer therapy 
A sulfur dioxide polymer prodrug showing combined effect with doxorubicin in combating subcutaneous and metastatic melanoma被引量：4
《Bioactive Materials》2021年第5期1365-1374,共10页Lin An Peng Zhang Wei Shen Xuan Yi Weitian Yin Rihua Jiang Chunsheng Xiao 
supported by the National Natural Science Foundation of China(51803209,51773196,and 51573184);the Jilin Provincial Science and Technology Development Program(20190201205JC,20190103022JH,and 20190103038JH);the Youth Innovation Promotion Association of Chinese Academy and Sciences(2017266).
Melanoma,as the most aggressive and treatment-resistant skin malignancy,is responsible for about 80%of all skin cancer mortalities.Prone to invade into the dermis and form distant metastases significantly reduce the p...
关键词：Glutathione-responsive Melanoma Polymer prodrug Sulfur dioxide 
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