CROTOXIN

作品数:5被引量:17H指数:3
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相关领域:医药卫生生物学更多>>
相关作者:颜次慧吴祥胜龚珊吴殿臣秦正红更多>>
相关机构:苏州大学更多>>
相关期刊:《苏州大学学报(医学版)》《Acta Pharmacologica Sinica》更多>>
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Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38 MAPK signaling pathway被引量:4
《Acta Pharmacologica Sinica》2014年第10期1323-1332,共10页Rong HAN Hui LIANG Zheng-hong QIN Chun-yu LIU 
Aim: Crotoxin (CrTX) is the primary toxin in South American rattlesnake (Crotalus durissus terrificus) venom, and exhibits antitumor and other pharmacological actions in vivo and in vitro. Here, we investigated t...
关键词:human lung carcinoma snake venom CROTOXIN cell cycle arrest APOPTOSIS AUTOPHAGY caspase-3 proliferating cell nuclearantigen p38 MAPK SB203580 
Growth inhibitory effects and molecular mechanisms of crotoxin treatment in esophageal Eca-109 cells and transplanted tumors in nude mice被引量:3
《Acta Pharmacologica Sinica》2013年第2期295-300,共6页Jing-kang HE Xiang-sheng WU Yan WANG Rong HAN Zheng-hong QIN Yan XIE 
Aim: To investigate the antitumor actions of the Crotalus durissus neurotoxin (crotoxin) on human esophageal carcinoma (Eca-109) cells in vitro and transplanted esophageal Eca-109 tumors in nude mice. Methods: T...
关键词:Crotalus durissus neurotoxin (Crotoxin) human esophageal Eca-109 cells apoptosis p15 caspase-3 p17 Bcl-2 G1 phaseblock transplant tumor 
Anti-tumor activity of CrTX in human lung adeno- carcinoma cell line A549被引量:7
《Acta Pharmacologica Sinica》2011年第11期1397-1401,共5页Bin YE Yan XIE Zheng-hong QIN Jun-chao WU Rong HAN Jing-kang HE 
Aim: To assess the cytotoxic effect of crotoxin (CrTX), a potent neurotoxin extracted from the venom of the pit viper Crotalus durissus terrificus, in human lung adenocarcinoma A549 cells and investigated the under...
关键词:crotoxin (CrTX) human lung adenocarcinoma apoptosis  P38MAPK caspase-3 cell cycle p53 ANGIOGENESIS 
Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells被引量:3
《Acta Pharmacologica Sinica》2007年第4期540-548,共9页Ci-hui YAN Ya-ping YANG Zheng-hong QIN Zhen-lun GU Paul REID Zhong-qin LIANG 
Aim: To investigate the role of crotoxin (CrTX)-induced autophagy in the death of MCF-7 cells, a caspase-3-deficient, human breast cancer cell line. Methods: Cultured MCF-7 cells were treated with various doses of...
关键词:CROTOXIN AUTOPHAGY APOPTOSIS CYTOCHROMEC apoptosis inducing factor 
南美洲响尾蛇神经毒素对丘脑束旁核神经元痛诱发放电的影响
《苏州大学学报(医学版)》2006年第5期728-733,共6页吴殿臣 蒋星红 龚珊 秦正红 周希平 
美国Receptogen公司;苏州大学基础医学系神经细胞分化发育重点实验室资助
目的以大鼠丘脑束旁核(Pf)神经元痛诱发放电为指标,来验证南美洲响尾蛇神经毒素(crotoxin)的镇痛作用。方法用玻璃微电极细胞外记录Pf神经元的单位放电,用电脉冲刺激坐骨神经作为伤害性刺激,诱发伤害性反应,观察侧脑室注射(i.c.v.)不同...
关键词:南美洲响尾蛇神经毒素(crotoxin) 束旁核 单位放电 镇痛 
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