A novel synthesis of C2-spiroindoline derivatives based on the cascade reaction of 2-aryl-3H-indoles with cyclo- propanols is presented. The formation of product involves Rh(III)-catalyzed aryl C(sp2)—H bond alkylati...
supported by National Natural Science Foundation of China(Nos.U23A20516,81922070,82273897 and 52303191);National Key Research and Development Program of China(No.2022YFC3502000);Shanghai Science and Technology Innovation Action Plans(21S21900600,China);the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02,China);Shanghai Municipal Health Commission’s TCM research project(No.2022CX005,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004,China);the State Key Laboratory of Fine Chemicals,Dalian University of Technology(No.KF 2202,China);Shanghai University of Traditional Chinese Medicine(No.2021LK023,China).
The aryl hydrocarbon receptor(AhR)plays a crucial role in regulating many physiological processes.Activating the AhReCYP1A1 axis has emerged as a novel therapeutic strategy against various inflammatory diseases.Here,a...
financial support from the National Natural Science Foundation of China(Nos.22071062,22001077 and 22271096);Guangdong Science and Technology Department(Nos.2021A1515012331,2023A1515011001);the Fundamental Research Funds for the Central Universities(No.2022ZYGXZR016);South China University of Technology for start-up funds。
Axially chiral binaphthol have achieved great success in asymmetric catalysis.Compared toα-binaphthol,axially chiral aryl-β-naphthol are far less reported.Here,we report a method of asymmetric catalysis to construct...
supported by the National Natural Science Foundation of China(22071028,21921003).
Conjugate addition and allylic substitution are two essential chemical transformations,and they could be competitive for substrates with multiple reactive sites.Herein,we report the diversified enantioselective synthe...
Tertiary phosphines and their oxides react with oxalyl bromide to generate corresponding quaternary phosphonium salts,which can be further transformed as active intermediates to facilitate the bromination of alcohols ...
Innovation Capability Support Program of Shaanxi,Grant/Award Number:2024RS‐CXTD‐57;Innovation Foundation for Doctor's Dissertation of Northwestern Polytechnical University,Grant/Award Number:CX2023026;Undergraduate Innovation&Business Program in Northwestern Polytechnical University,Grant/Award Number:202310699253。
Fluorene-containing branched poly(aryl-ether-ketone)(BFPAEK)with terminal hydroxyl groups is synthesized by random copolycondensation reaction;then,the CF@BFPAEK/PEEK laminated composite is prepared by the“powder imp...
the National Natural Science Foundation of China(No.22078150);the Natural Science Foundation of Jiangsu Province,Frontier Project(No.BK20212003)for their financial support;the RGC of Hong Kong(No.14308922);the Guangdong Research Fund(No.2022A1515010955);CUHK Direct Grant(No.4053559)。
An oxidative annulation of 2-arylidene-1,3-indanediones with Meldrum's acid has been developed for the divergent syntheses of spirolactones with a spirocenter located at theγ-position with respect to the carbonyl gro...
Atomically-dispersed metal-based materials represent an emerging class of photocatalysts attributed to their high catalytic activity,abundant surface active sites,and efficient charge separation.Nevertheless,the roles...
An efficient and sustainable protocol for regioselective hydrocarboxylation of alkynes to construct diverse propionic acid derivatives is disclosed.Under photoinduced conditions,the anti-Markovnikov hydrocarboxylation...
Allylic amines and 1,3-oxazinanes are valuable molecular skeletons in organic synthesis and pharmaceutical industry.A straightforward way to such two types of compounds by solvent-controlled rare-earth metal Lewis aci...