SPHINGOSINE

作品数：80被引量：236H指数：8
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相关领域：医药卫生更多>>
相关作者：张翼肖琼尹大力徐美林王菁更多>>
相关机构：北京协和医学院首都医科大学天津市胸科医院天津医科大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金北京市自然科学基金国家重点基础研究发展计划更多>>
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Down-regulation of miR-155 inhibits inflammatory response in human pulmonary microvascular endothelial cells infected with influenza A virus by targeting sphingosine-1-phosphate receptor 1被引量：2
《Chinese Medical Journal》2020年第20期2429-2436,共8页Si-Mei Shen Hao Jiang Jiang-Nan Zhao Yi Shi 
a grant from the National Nature Science Foundation of China(No.81470206).
Background:Endothelial cells play a key role in the cytokine storm caused by influenza A virus. MicroRNA-155 (miR-155) is an important regulator in inflammation. Its role in the inflammatory response to influenza A in...
关键词：MicroRNA-155 Sphingosine 1-phosphate receptor 1 Influenza A virus Endothelial cells 
The sphingosine-1-phosphate/RhoA/Rho associated kinases/myosin light chain pathway in detrusor of female rats is down-regulated in response to ovariectomy被引量：1
《Chinese Medical Journal》2020年第10期1203-1210,共8页Wei Zhang Xiao-Dong Liu Jia-Wen Wang Ling-Feng Meng Yao-Guang Zhang Jian-Ye Wang 
This study was supported by a grant of the National Key Research&Development Program of China(No.2018YFC2002202).
Background:Dysuria is one of the main symptoms of genitourinary syndrome of menopause,which causes serious disruption to the normal life of peri-menopausal women.Studies have shown that it is related to decrease of de...
关键词：Myosin light chains OVARIECTOMY Rats Rho-associated kinases Sphingosine-1-phosphate Urinary bladder 
Sphingosine-1-phosphate signal transducer and activator of transcription 3 signaling pathway contributes to baicalein-mediated inhibition of dextran sulfate sodium-induced experimental colitis in mice被引量：6
《Chinese Medical Journal》2020年第3期292-300,共9页Jing Yao Tao Liu Rui-Jiao Chen Jing Liang Jun Li Chuan-Gong Wang 
This work was supported by the grants from the National Natural Science Foundation of China(Nos.81603143,21807041);Shandong Medical and Health Science and Technology Development Project(Nos.2017WS646,2017WS653);Teachers'Research Support Fund of Jining Medical University(No.JYFC2018KJ037);National Natural Science Foundation Breeding Programs of Jining Medical University(No.JYP201708).
Background:Baicalein has been shown to have anti-inflammatory and anti-tumor activities.However,the mechanisms underlying its anti-inflammatory effect on colitis remain unclear.Methods:A dextran sodium sulfate(DSS)-in...
关键词：BAICALEIN COLITIS STAT3 SPHINGOSINE kinase 1 
Sphingosine Kinase-1/sphingosine 1-phosphate pathway in diabetic nephropathy被引量：6
《Chinese Medical Journal》2014年第16期3004-3010,共7页Deng Yanhui Lan Tian Huang Juan Huang Heqing 
This work was supported by research grants from the Natural Science Foundation of China （No. 81170676, 81373457） and Natural Science Foundation of Guangdong Province （No.S2012020010991, S2013010015765）.
Objective Diabetic nephropathy （DN） is the major cause of end-stage renal disease worldwide and its prevalence continues to increase.Currently,therapies for DN provide only partial renoprotection; hence new targets ...
关键词：diabetic nephropathy sphingosine kinase-1 sphingosine 1-phosphate FIBROSIS transforming growth factor-β extracellular matrix 
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