生物过程

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Research progress in quantifying the mechanical properties of single living cells using atomic force microscopy被引量：8
《Chinese Science Bulletin》2014年第31期4020-4029,共10页Mi Li Lianqing Liu Ning Xi Yuechao Wang 
supported by the NationalNatural Science Foundation of China(61175103,61327014);CASFEA International Partnership Program for Creative Research Teams
The advent of atomic force microscopy(AFM)provides a powerful tool for investigating the behaviors of single living cells under near physiological conditions.Besides acquiring the images of cellular ultra-microstructu...
关键词：单个活细胞 原子力显微镜 机械性能 AFM 生物过程 纳米分辨率 生物学功能 生理条件 
Applications of polymer single nanochannels in biosensors被引量：4
《Chinese Science Bulletin》2013年第13期1473-1482,共10页HOU GuangLei PENG ZhiJian TIAN Ye ZHANG HuaCheng JIANG Lei 
supported by the National Basic Research Program of China (2011CB935700);National Natural Science Foundation of China(21201170, 11290163, 21121001, 91127025, 21171171);Key Research Program of the Chinese Academy of Sciences (KJZD-EW-M01);Beijing National Laboratory for Molecular Sciences (CMS-PY-201243)
There are many elaborate masterpieces exist in natural world. Learning from nature, people developed serial intelligent biomimetic devices. Biomimetic smart nanochannels received widespread attention for mimicking bio...
关键词：生物传感器 纳米通道 聚合物 应用 纳米尺寸效应 仿生智能 生物过程 表面特性 
Single-molecule fluorescence imaging of membrane-bound proteins for studies of cell signal transduction被引量：1
《Chinese Science Bulletin》2011年第11期1063-1067,共5页YANG Yong, XIA Tie ZHANG Wei FANG XiaoHong 
supported by the National Basic Research Program of China(2007CB935601);the National Natural Science Foundation of China(90713024,20821003);the Chinese Academy of Sciences
Fluorescence imaging of single molecules is becoming a powerful tool to examine biological processes at the molecular level.Using total internal reflection fluorescence microscopy (TIRFM),it has been possible to study...
关键词：细胞信号转导 单分子膜 荧光成像 结合蛋白 生长因子受体 荧光显微镜 单分子成像 生物过程 
Ranking effects of candidate drugs on biological process by integrating network analysis and Gene Ontology被引量：7
《Chinese Science Bulletin》2010年第26期2974-2980,共7页LI LiSha ZHANG NingBo LI Shao 
supported by the National Natural Science Foundation of China (30873464 and 60934004);National High-Tech Research & Development Program of China (2006AA02Z311)
There are high preclinical attrition rates in current drug discovery. The efficient assessment approach in the high throughout candidate drugs screening still needs great improvement. We propose two hypotheses. First,...
关键词：基因本体论 药物作用 生物过程 网络分析 过程集成 人脐静脉内皮细胞 细胞迁移 产物分析 
Predicted methylation landscape of all CpG islands on the human genome被引量：2
《Chinese Science Bulletin》2010年第22期2353-2358,共6页FAN ShiCai ZOU JianXiao XU HongBing ZHANG XueGong 
supported by the National Natural Science Foundation of China (30625012 and 60721003);National Basic Research Program of China (2004CB518605)
CpG island methylation plays important role in various biological processes. To investigate methylation landscape of all CpG islands on the human genome, we develop a model for predicting the CpG island methylation st...
关键词：DNA甲基化 人类基因组 CPG岛 景观 预测 RNA聚合酶 基因启动子 生物过程 
Identifying changed protein-protein interactions in biological processes by gene coexpression analysis
《Chinese Science Bulletin》2010年第14期1396-1402,共7页ZHANG Ting ZHANG XueGong SUN ZhiRong 
supported in part by the National Natural Science Foundation of China (Grant Nos. 30770498, 30625012 and 60721003);the National High-Tech Research and Development Program of China (Grant No.2006AA020403);the National Basic Research Program of China (Grant No.2009CB918801)
The interaction strength between 2 proteins is not constant but variable under different conditions. For a given biological process, identification of protein-protein interactions (PPIs) undergoing dynamic change in i...
关键词：蛋白质相互作用 相互作用力 生物过程 表达分析 基因 识别 价格指数 转化生长因子 
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