Subsequent to demyelination in multiple sclerosis, myelin repair occurs but, as lesions age, the ability to remyelinate diminishes. Molecular pathways underl ying oligodendrocyte behaviour during CNS remyelination rem...
Skin biopsy is a minimally invasive procedure and has been used in the evaluation of non-myelinated, but not myelinated nerve fibres, in sensory neuropathies . We therefore evaluated myelinated nerves in skin biopsies...
Background: Myelin protein zero gene (MPZ) mutations may account for a small p roportion of cases of Charcot-Marie-Tooth disease (CMT). Different MPZ mutatio ns may be associated with different clinical and electrophy...
Rituximab, a monoclonal antibody against B-cell membrane marker CD-20, is an effective treatment for immunoglobulinM (IgM) monoclonal anti-myelin-associat ed glycoprotein(MAG) neuropathies. We report a patient with an...
Anti-myelin-associated glycoprotein (anti-MAG) neuropathy is a chronic demy elinating neuropathy with predominant involvement of large sensory fibers and de posits of IgM and complement on sural nerve myelinated fiber...
Activated myelin specific T cells are thought to mediate inflammatory tissue damage in multiple sclerosis (MS). Applying a large panel of myelin antigens, we demonstrate the direct ex vivo detection of viable IFN γ/T...