Our previous work demonstrated that microinjection of OFQ into PAG antagonized e lectroacupuncture (EA) analgesia; increased the release of Glu in spinal dorsal horn and decreased the release of GABA, 5 HT and NE; and...
Nociceptin (also named Orphanin FQ), plays a very important role in spinal pain modulation. The present study was designed to explore the effect of nociceptin o n neuropathic pain in rats with chronic constrictive inj...
It was suggested that the nucleus submedius (Sm) in the medial thalamus and the ventrolateral orbital cortex (VLO) in the prefrontal cortex were involved not only in nociception, but also in modulation of nociception....