supported by grants from the National Natural Science Foundation of China(21202066);the Natural Science Foundation of Yunnan Province,China(2012FB156);the project for Excelient Young Teccher of Kunming Medical University and Yunan Province(J1301306611,6011521120);the Foundation from Educational Department of Yunnan Province(2015Y151);the Open Research Foundation of Yunnan Key Laboratory of Pharmacology for Natural Products(2014G011)