supported by the National Natural Science Foundation of China(62174059,51872099,and 91963102);Hong Kong Research Grant Council(15300619);Science and Technology Program of Guangzhou(201905-0001);Guangdong Science and Technology ProjectInternational Cooperation(2021A0505030064);the Program for Chang Jiang Scholars and Innovative Research Teams in Universities(IRT_17R40);the 111 Project。