In a recent paper published in Cell, Wang et al. report that deficiency of triggering receptor expressed on myeloid cells 2 (TREM2) augments amyloid β accumulation and neuronal loss in a mouse model of Alzheimer's...
A recent study published in Nature by Keestra and colleagues addresses how the immune system detects the pathogenic potential of microbes and provides evidence that one strategy involves NOD1, which monitors the activ...
Intracellular NOD-like receptor (NLR) proteins are believed to play important roles in innate immune detection or immune regulation, but only a few NLR proteins are functionally defined. Recent intensive studies, la...
Dear Editor, Auxin-signaling F-box protein 4 (AFB4) encoded by At4g24390 shares a significant sequence similarity to auxin receptor TIR1. In this study, we used a combination of physiological, molecular, and geneti...
MHC molecules have been shown to play key roles in the immune system including regulating T-cell repertoire development through the process of positive and negative selection. MHC molecules also function to bridge the...