supported by the National Key Research and Development Program of China (2020YFA0908200);the National Natural Science Foundation of China (T2225003,61927805,and 52073060);the Nanjing Medical Science and Technique Development Foundation (ZKX21019);the Clinical Trials from Nanjing Drum Tower Hospital (2022-LCYJ-ZD-01);Guangdong Basic and Applied Basic Research Foundation (2021B1515120054);the Shenzhen Fundamental Research Program (JCYJ20190813152616459 and JCYJ20210324133214038);Jiangsu Funding Program for Excellent Postdoctoral Talent (2022ZB710);China Postdoctoral Science Foundation (2022TQ0145 and 2022M721581)。