supported by the National Chinese Medicine Clinical Research Base Construction Project[Science and Technology Letter of Traditional Chinese Medicine in China,No.[2018]131);Key Research and Development Project of Ministry of Science and Technology of the People's Republic of China(2018YFC1704100,2018YFC1704102);Science and Technology Planning Project of Hebei Provincial Administration of Traditional Chinese Medicine(2022043);Hebei Provincial Science and Technology Planning Project(21377724D,21377740D).