supported by grants from the National Natural Science Foundation of China[82070574,818004580];the Nature Science Foundation Team Project of Guangdong Province[2018B03031200].
Background:Intestinal barrier defect is an essential inflammatory bowel disease(IBD)pathogenesis.Mitochondrial dysfunction results in energy deficiency and oxidative stress,which contribute to the pathogenesis of IBD....
BACKGROUND Portal hypertension,a common complication associated with liver cirrhosis,can result in variceal bleeding,which greatly impacts patient survival.Recently,β-arrestin-2 has been shown to predict the acute he...
Supported by the National Natural Science Foundation of China,No.81470848;the Breeding Foundation for Young Pioneers’Research of Sun Yat-sen University,No.14ykpy27
AIM To study the role and the possible mechanism of β-arrestin 2 in lipopolysaccharide(LPS)-induced liver injury in vivo and in vitro.METHODS Male β-arrestin 2^(+/+) and β-arrestin 2^(-/-)C57 BL/6 J mice were used ...