funded by University of Macao(File no.MYRG2018-00165-ICMS and MYRG2016-152-ICMS);National Natural Science Foundation of China(81973516);The Science and Technology Development Fund,Macao SAR(File no.176/2017/A3)。
Osimertinib(AZD9291)has been widely used for the treatment of EGFR mutant non-small cell lung cancer.However,resistance to osimertinib is inevitable.In this study we elucidated the molecular mechanisms of resistance i...