阿尔茨海默氏病

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Re-mention of an old neurodegenerative disease:Alzheimer's disease被引量：2
《Chinese Science Bulletin》2013年第15期1731-1736,共6页ZHANG Peng ADAMS Ursula YUAN ZengQiang 
supported in part by the National Natural Science Foundation of China (81030025 and 81125010);the National Basic Research Program of China (2009CB918704)
Alzheimer's disease(AD),the most common form of neuropsychiatric disorder,is characterized by neuronal degeneration and inexorably progressing dementia,especially in the elderly population.With a rapidly aging populat...
关键词：神经退行性疾病 阿尔茨海默氏症 阿尔茨海默氏病 Complex 老年痴呆症 神经细胞死亡 淀粉样蛋白 精神障碍 
Amyloid precursor protein-mediated modulation of capacitive calcium entry
《Chinese Science Bulletin》2012年第35期4552-4559,共8页MA Tuo NIU Ying ZHAO Chang SU ZuQi AO Qiang ZHANG XiuFang ZHAO NanMing GONG YanDao 
supported by the State Key Laboratory of Biomembrane and Membrane Biotechnology;the National Natural Science Foundation of China(NSFC)/Research Grants Council of Hong Kong(RGC) Joint Research Scheme(81161160570);Tsinghua-Yue-Yuen Medical Sciences Fund(20240000514)
Alzheimer's disease(AD) is a progressive neurodegenerative disorder.In the present study,the function of amyloid precursor protein(APP) in modulating capacitive calcium entry(CCE),a refilling mechanism for depleted in...
关键词：淀粉样前体蛋白 细胞内钙库 电容 调制 蛋白质 神经变性疾病 阿尔茨海默氏病 胚胎成纤维细胞 
What can false memory tell us about memory impairments in Alzheimer's disease?被引量：3
《Chinese Science Bulletin》2010年第35期3989-3997,共9页ZHANG Fan GENG HaiYan 
supported by the National Natural Science Foundation of China (30870763);Beijing Municipal Natural Science Foundation (7093123);the Fundamental Research Funds for the Central Universities
The range of memory impairments associated with Alzheimer's disease(AD) has been a focus for psychological and clinical researchers for many years.In addition to investigations of AD patients' veridical memory using t...
关键词：阿尔茨海默氏病 记忆障碍 虚假广告 监控能力 联想记忆 精神障碍 记忆能力 老年人 
Modulation of long-term potentiation in the hippocampus by pharmacological approach:A novel strategy for the development of cognitive enhancers
《Chinese Science Bulletin》2010年第30期3374-3382,共9页YANG YuanJian WU PengFei WANG Fang CHEN Jian Guo 
supported by the National Basic Research Program of China (2007CB507404);the Chang Jiang Scholar Program of the Ministry of Education of China,the Key Project of National Natural Science Foundation of China (30930104);the Program for New Century Excellent Talents in Universities of China (NCET-08-0225)
Learning and memory not only provide the foundations of cognition, but are also closely related to sensory and motor function. Neurodegenerative conditions such as Alzheimer's disease and Parkinson's disease are accom...
关键词：药物治疗 海马 生物活性物质 阿尔茨海默氏病 突触传递 电位 调制 分子机制 
The mitochondrial function was impaired in APP knockout mouse embryo fibroblast cells被引量：2
《Chinese Science Bulletin》2009年第10期1725-1731,共7页SHENG BaiYang NIU Ying ZHOU Hui ZHOU Hui YAN JiaXin ZHAO NanMing ZHANG XiuFang GONG YanDao 
Supported by Tsinghua-Yue-Yuen Medical Sciences Fund (Grant No. 20240000514);Science and Technology Planning Project of Beijing Municipal (Grant No. H060920050430);State Key Laboratory of Biomembrane and Membrane Bio-technology
The amyloid precursor protein (APP) is recognized as the source of Aβ, which plays an important role in Alzheimer’s disease. However, the biological function of APP is obscure. Previous studies showed that mitochond...
关键词：胚胎成纤维细胞 线粒体膜电位 亚洲 功能障碍 小鼠 细胞色素C氧化酶 阿尔茨海默氏病 应用程序 
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