MULTIDRUG_RESISTANCE

作品数：306被引量：1254H指数：19
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Rising above:exploring the therapeutic potential of natural product-based compounds in human cancer treatment
《Traditional Medicine Research》2025年第3期56-74,共19页Li-Yan Yang Shi-Zeng Lei Wen-Jing Xu Yu-Xin Lai Ying-Ying Zhang Ying Wang Zhong-Lei Wang 
supported by the National Natural Science Foundation of China(grant number 22309103);Natural Science Foundation of Shandong Province(grant numbers ZR2022MH162,ZR2022QE202);PhD Research Start-up Foundation of Qufu Normal University(grant numbers 614901,615201);the project of introduction and cultivation for young innovation talents in the colleges and universities of Shandong Province(grant number 614202).
Tumors,due to their diversity and heterogeneity,pose a significant threat to human health.Multidrug resistance is a prevalent and grave issue in clinical treatment,resulting in treatment failure and cancer recurrence....
关键词：TUMORS multidrug resistance natural products CAMPTOTHECIN future challenges 
Overcoming antibiotic-resistant Helicobacter pylori infection:Current challenges and emerging approaches
《World Journal of Gastroenterology》2025年第10期7-29,共23页Gabriel Reis Rocha Fabian Fellipe Bueno Lemos Luis Guilherme de Oliveira Silva Marcel Silva Luz Gabriel Lima Correa Santos Samuel Luca Rocha Pinheiro Mariana Santos Calmon Fabrício Freire de Melo 
Supported by the Industrial Technological Initiation Scholarship of National Council for Scientific and Technological Development,CNPq,Brazil,No.0932204294929829 and No.7414780530977345;the Scientific Initiation Scholarship Programme(PIBIC)of National Council for Scientific and Technological Development,CNPq,Brazil,No.5763023359532159,No.6472982965854452,and No.7340128440641417;the Scientific Initiation Scholarship Programme(PIBIC)of Bahia State Research Support Foundation,FAPESB,Brazil,No.19.573.301.5418;the PERMANECER Programme of Pro-Rectory of Student Assistance at Federal University of Bahia,No.R8EZ-4V4W-6LQX-5LC8;the CNPq Research Productivity Fellow,No.4357511882624145.
Recent studies have shown a noticeable increase in global Helicobacter pylori(H.pylori)resistance,with clarithromycin resistance surpassing 15%in various areas.However,inadequate epidemiological monitoring,especially ...
关键词：Helicobacter pylori Antibiotic resistance Multidrug resistance HETERORESISTANCE Empirical treatment Antimicrobial susceptibility testing 
Tumor microenvironment-responsive drug self-delivery systems to treat cancer and overcome MDR
《Rare Metals》2025年第1期1-33,共33页Ling-Mei Li Yi-Pin Xie Yu-Rong Qin Hai-Ping Chu Hui Xie De-Jin Zang Teng Liu 
supported by the National Natural Science Foundation of China(No.21907059);Shandong Province Chinese Medicine Science and Technology Development Project(No.M-2022258);the Young Scientist Development Foundation of Shandong First Medical University(No.202201-002);the Academic Promotion Program of Shandong First Medical University(Nos.2019LJ003 and 2019QL011).
Tumor microenvironment-responsive drug self-delivery systems utilize tumor microenvironment-responsive chemical bonds to link anti-tumor drugs,exploiting the hydrophilic and hydrophobic properties of different drugs t...
关键词：Drug self-delivery system Metal drug Tumor microenvironment response Drug carrier Tumor multidrug resistance 
Sunlenca■(Lenacapavir):A first-in-class,long-acting HIV-1 capsid inhibitor for treating highly multidrug-resistant HIV-1 infection
《Acta Pharmaceutica Sinica B》2024年第12期5512-5514,共3页Chunhua Ma Junbiao Chang Bin Yu 
support from the National Natural Science Foundation of China(Nos.22277110 and 82003585)and Tianjian Laboratory of Advanced Biomedical Sciences.
Lenacapavir,also known as GS-6207,under the brand name Sunlenca,was developed by Gilead Sciences Inc.It has been approved in the EU,Canada,and US for use alongside other antiretrovirals in adults with multidrug-resist...
关键词：Lenacapavir Capsid inhibitor HIV-1 infection HIV prevention Multidrug resistance Antiretroviral medication 
Hyperkouytones A—O,New Polyprenylated Acylphloroglucinols from Hypericum kouytchense with Multidrug Resistance Reversal Activity
《Chinese Journal of Chemistry》2024年第24期3293-3307,共15页Hua-Yong Lou Mei-Jun Chen Ping Yi Jun Jin Yan-Rong Zeng Wei Gu Zhan-Xing Hu Jue Yang Xiao-Jiang Hao Chun-Mao Yuan 
supported by the National Natural Science Foundation of China(Nos.32270413,82060631,and 82304348);the Science and Technology Department of Guizhou Province(No.QKHJC-ZK[2023]YB156);Excellent Young Talents Plan of Guizhou Medical University(2023,No.106);the 13th batch of outstanding young scientific and technological talents in Guizhou Province(No.QKHPTRC[2021]5633);Guizhou Science and Technology Innovation Talent Team(No.QKHPTRCCXTD[2022j007);High-level Innovative Talents in Guizhou Province(Thousand Levels of Talent for Chunmao Yuan in 2018);Guiyang Science and Technology Talent Training Project([2023]48-5);the project of State Key Laboratory of Functions and Applications of Medicinal Plants,GuizhouMedical University(No.QJJ[2023]113);Guizhou Provincial Engineering Research CenterforNatural Drugs.
Given the lack of systematic polyprenylated acylphloroglucinols(PPAPs)research on traditional Chinese medicine of Hypericum kouytchense,this plant was applied for the phytochemical study,which led to fifteen new PPAP...
关键词：Natural products Hypericum kouytchense PHYTOCHEMISTRY Structure elucidation Multidrug resistance reversal activity 
SnoRNAs: The promising targets for anti-tumor therapy
《Journal of Pharmaceutical Analysis》2024年第11期1588-1602,共15页Xiaoyun Hu Wanlin Cui Min Liu Fangxiao Zhang Yingqi Zhao Mingrong Zhang Yuhang Yin Yalun Li Ying Che Xianglong Zhu Yuxuan Fan Xiaolan Deng Minjie Wei Huizhe Wu 
supported by grants from the National Natural Science Foundation of China(81872905,82272915,and 82073884);the Project of the Fourth Batch of Science and Technology Plan of Liaoning Province,China(Grant No.:2021JH210300133);Science and Technology Innovation Team Project of China Medical University,China(Grant No.:CXTD2022007);the Supporting the Highquality Development of Science and Technology Funding Projects at China Medical University(Grant No.:2022011963-JH2/202);China Postdoctoral Science Foundation(Grant No.:2023MD734246);Liaoning Province Natural Science Foundation Joint Fund(Grant No.:2023-MSLH-396)。
Recently,small nucleolar RNAs(snoRNAs)have transcended the genomic“noise”to emerge as pivotal molecular markers due to their essential roles in tumor progression.Substantial evidence indicates a strong association b...
关键词：SNORNA Cancer snoRNA host gene Multidrug resistance Targeted therapy Tumor immune microenvironment 
Study of the Multidrug Resistance of Enterobacteria Isolated from Waters and Tilapia Fishes from Fish Farms in the Sud-Comoé Region, Côte d’Ivoire
《Advances in Microbiology》2024年第11期567-577,共11页Affou Séraphin Wognin Aubin Cyrille Toulé Amoin Elise N’guessan Nangan Michel Koné Natalie Kouadio-Guessennd 
Microbial resistance to antibiotics is a global problem that threatens the lives of millions of people and affects several sectors, including aquaculture. The aim of the present study is to contribute to the monitorin...
关键词：Multidrug Resistance ENTEROBACTERIACEAE Tilapia Fish FISHPONDS 
Identification of FDA-Approved Drugs as Modulators of Multidrug Resistance Protein 2 (MRP2/ABCC2) Expression Levels in MRP2-Overexpressing Cells: Preliminary Data
《Journal of Biosciences and Medicines》2024年第10期32-44,共13页Vivian Osei Poku Surtaj Hussain Iram 
Multidrug Resistance Protein 2 (MRP2) is an ATP-dependent transmembrane protein that plays a pivotal role in the efflux of a wide variety of physiological substrates across the plasma membrane. Several studies have sh...
关键词：ABC Transporters Multidrug Resistance MRP2/ABCC2 MRP2 Modulators ELISA 
Abiotic Factors Associated with Abundance Dynamics and Antibiotic Multidrug Resistance of Escherichia coli and Enterococcus faecalis Isolated from Some Ombessa Aquatic Systems (Central Cameroon Region)
《Journal of Geoscience and Environment Protection》2024年第9期335-369,共35页Lucie Leme Banock Blandine Pulchérie Tamatcho Kweyang Fabrice Ezo’o Mengo Stephane Arthur Noah Eric Donald Mbo Zang Olive Vivien Noah Ewoti 
The present study conducted in the town of Ombessa aims to assess the influence of abiotic factors on the abundance dynamics and antibiotic susceptibility of Escherichia coli and Enterococcus faecalis isolated from so...
关键词：Bacterial Abundance MULTIRESISTANCE ABIOTIC AQUATIC 
Five-year analysis of isolated pathogens and antibiotic resistance of ocular infections from two large tertiary comprehensive hospitals in east China
《International Journal of Ophthalmology(English edition)》2024年第9期1707-1716,共10页Pan-Pan Li Li Li Jun-Fang Zhang Bai Qin Li-Hua Kang Min Ji Huai-Jin Guan 
Supported by National Natural Science Foundation of China(No.82101101).
AIM:To analyze the spectrum of isolated pathogens and antibiotic resistance for ocular infections within 5y at two tertiary hospitals in east China.METHODS:Ocular specimen data were collected from January 2019 to Octo...
关键词：ocular infections BACTERIA FUNGUS antibiotic resistance multidrug resistance 
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