Ca^(2+)signals have a crucial role in the immune system for cell functions such as proliferation,differentiation,apoptosis and gene transcription as well as the activation of Nuclear factor of activated T Cell(NFAT)wh...
Basic and Applied Basic Research Foundation of Guangdong Province,Grant/Award Number:2019A1515110723;Key Laboratory of Guangdong Higher Education Institutes,Grant/Award Number:2021KSYS009。
Background:Overproduction and activation of osteoclasts result in various bone diseases,such as osteoporosis,Paget's disease,and rheumatoid arthritis.Thus,inhibiting osteoclast formation and overactivation may effecti...
supported by National Natural Science Foundation of China(82273368,82073196,82204455);the National Key Research and Development Program of China(2021YFC2501900);Natural Science foundation of Guangdong Province(2021A1515011158,2021A0505030035,China);Guangdong Basic and Applied Basic Research Foundation Outstanding Youth Project(2023B1515020012,China);Guangzhou Science and Technology Project(202201020032,China);Key Laboratory of Guangdong Higher Education Institutes(2021KSY009,China);Open Project funded by the MOE Key Laboratory of Tumor Molecular Biology(2023 Open Project-50411651-2020-1,China)。
Increasing evidences suggest the important role of calcium homeostasis in hallmarks of cancer,but its function and regulatory network in metastasis remain unclear.A comprehensive investigation of key regulators in can...
supported by the National Natural Science Foundation of China(31770953,81830047,and 81961138008 to CX and 32070877 to W-HL),1000 Young Talents Program of China(NX);the Fundamental Research Funds for the Central Universities of China-Xiamen University(20720170064 to CX).
Cellular immunity mediated by CD8+T cells plays an indispensable role in bacterial and viral clearance and cancers.However,persistent antigen stimulation of CD8+T cells leads to an exhausted or dysfunctional cellular ...