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NGU: 作品数：272被引量：480H指数：9; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李学斌任军于志湖李明成卢桂玲更多>>; 相关机构：天津市长征医院中国医学科学院北京协和医学院北华大学山东省立医院更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广州市医药卫生科技项目更多>>

Diagnostic Efficiency of Tongue-Coating Microbiome in Patients With SARS-CoV-2 Omicron Variant Infection and Recovery: 《Infectious Microbes & Diseases》2025年第1期54-64,共11页Junyi Sun Ying Sun Yawen Zou Haiyu Wang Benchen Rao Xinyue Zhang Liwen Liu Guizhen Zhang Guangying Cui Qi Liu Jiyuan Xing Ning Xu Chunfu Zheng Zujiang Yu Zhigang Ren; supported by grants from the National Key Research and Development Program of China(2022YFC2303100);the Henan Province Epidemic Prevention and Control Emergency Scientific Research Project(221111311700 and 221111311600);the Independent and Innovation Project for Graduate Students of Zhengzhou University(20230444);Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University(QNCXTD2023002).; SARS-CoV-2 variants still pose threats to human public health.However,there has been little research regarding alterations in the tongue-coating microbiome in patients infected with the Omicron variant(PIOVs).Herein,w...; 关键词：COVID-19 SARS-CoV-2 Omicron variant recovery patients tongue-coating microbiome

Protein engineering in the deep learning era: 《mLife》2024年第4期477-491,共15页Bingxin Zhou Yang Tan Yutong Hu Lirong Zheng Bozitao Zhong Liang Hong; supported by the National Natural Science Foundation of China(11974239 and 62302291);Innovation Program of Shanghai Municipal Education Commission(2019‐01‐07‐00‐02‐E00076);Shanghai Jiao Tong University Scientific and Technological Innovation Funds(21×010200843)。; Advances in deep learning have significantly aided protein engineering in addressing challenges in industrial production,healthcare,and environmental sustainability.This review frames frequently researched problems in...; 关键词：artificial intelligence geometric deep learning protein engineering protein language model synthetic biology

Optimizing enzyme thermostability by combining multiple mutations using protein language model: 《mLife》2024年第4期492-504,共13页Jiahao Bian Pan Tan Ting Nie Liang Hong Guang‐Yu Yang; supported by the Key‐Area Research and Development Program of Guangdong Province,China(2022B1111050001);the National Natural Science Foundation of China(Grant Nos.32030063 and 32371483);the Shanghai Pilot Program for Basic Research‐Shanghai Jiao Tong University.; Optimizing enzyme thermostability is essential for advancements in protein science and industrial applications.Currently,(semi‐)rational design and random mutagenesis methods can accurately identify single‐point mut...; 关键词：combinatorial mutants CREATINASE EPISTASIS protein language model thermostability

TPpred-SC:multi-functional therapeutic peptide prediction based on multi-label supervised contrastive learning: 《Science China(Information Sciences)》2024年第11期132-143,共12页Ke YAN Hongwu LV Jiangyi SHAO Shutao CHEN Bin LIU; supported by National Natural Science Foundation of China(Grant Nos.62325202,62102030,U22A2039);Beijing Natural Science Foundation(Grant No.L232067)。; Therapeutic peptides contribute significantly to human health and have the potential for personalized medicine.The prediction for the therapeutic peptides is beneficial and emerging for the discovery of drugs.Although...; 关键词：therapeutic peptide prediction multi-label classification pretrained protein language model multi-label supervised contrastive learning

Investigation of the first quasi-rectangular metro tunnel constructed by the 0-θ method: 《Frontiers of Structural and Civil Engineering》2023年第11期1707-1722,共16页Peinan LI Xue LIU Xi JIANG Xuehui ZHANG Jun WU Peixin CHEN; theSSocial Development Project of Science and Technology Commission of Shanghai Municipality(No.21DZ1201105);the Fundamental Research Funds for the Central Universities(No.21D111320);the National Natural Science Foundation of China(Grant No.42201489).; Quasi-rectangular shield tunneling is a cutting-edge trenchless method for constructing metro tunnels with double tubes,owing to its advantages in saving underground space and reducing ground disturbance.However,the c...; 关键词：quasi-rectangular tunnel O-0 method pipe jacking shield tunneling underground space

Tongue-coating microbiome reflects cardiovascular health and determines outcome in blood pressure intervention被引量：1: 《Journal of Genetics and Genomics》2023年第10期803-806,共4页Hairong Chen Yue Ma Min Li Qingwei Li Mengya Zhang Zixiong Wang Hongmei Liu Jun Wang Xiaolin Tong Yixin Zeng; supported by the Key Research Program of the Chinese Academy of Sciences under Grant KJZD-SW-L05 to Yixin Zeng and KJZD-SW-L05-04 to Hairong Chen;the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Nos.ZYYCXTD-D-202001)to Jun Wang。; Tongue-coating microbiome,as a part of oral microbiome,is an important part of commensal microbes in human body.Despite technical difficulties in gaining functional insights using metagenomic approaches due to high le...; 关键词：CARDIOVASCULAR diseases coating

NetGO 3.0:Protein Language Model Improves Large-scale Functional Annotations被引量：1: 《Genomics, Proteomics & Bioinformatics》2023年第2期349-358,共10页Shaojun Wang Ronghui You Yunjia Liu Yi Xiong Shanfeng Zhu; supported by the National Natural Science Foundation of China(Grant Nos.61872094 and 62272105);the Shanghai Municipal Science and Technology Major Project(Grant No.2018SHZDZX01);the ZJ Lab,and the Shanghai Research Center for Brain Science and Brain-Inspired Intelligence Technology.Shaojun Wang and Ronghui You have been supported by the lll Project(Grant No.B18015);the Shanghai Municipal Science and Technology Major Project(Grant No.2017SHZDZX01);the Information Technology Facility,CAS-MPG Partner Institute for Computational Biology,Shanghai Institute for Biological Sciences,Chinese Academy of Sciences.Yi Xiong has been supported by the National Natural Science Foundation of China(Grant Nos.61832019 and 62172274).; As one of the state-of-the-art automated function prediction(AFP)methods,NetGO 2.0 integrates multi-source information to improve the performance.However,it mainly utilizes the proteins with experimentally supported f...; 关键词：Protein function prediction Web service Protein language model Learning to rank Large-scale multi-label learning

Genetic differentiation between and within Northern Native American language groups:an argument for the expansion of the Native American CODIS database: 《Forensic Sciences Research》2022年第4期662-672,共11页Jessica A.Weise Jillian Ng Robert F.Oldt Joy Viray Kelly L.McCulloh David Glenn Smith Sreetharan Kanthaswamy; This study was funded by a National Institute of Justice grant[grant number 2014-DN-BX-K024]to Sreetharan Kanthaswamy,and a research grant from the UC Davis Forensic Science Graduate Program to Jessica A.Weise.; The National Research Council recommends that genetic differentiation among subgroups of ethnic samples be lower than 3%of the total genetic differentiation within the ethnic sample to be used for estimating reliable ...; 关键词：Forensic sciences population genetics Native Americans North America languages short tandem repeats(STRs or microsatellites)

Comparison of algorithms for monitoring wheat powdery mildew using multi-angular remote sensing data被引量：3: 《The Crop Journal》2022年第5期1312-1322,共11页Li Song Luyuan Wang Zheqing Yang Li He Ziheng Feng Jianzhao Duan Wei Feng Tiancai Guo; supported by the National Natural Science Foundation of China (31971791);the National Key Research and Development Program of China (2017YFD0300204)。; Powdery mildew is a disease that threatens wheat production and causes severe economic losses worldwide. Its timely diagnosis is imperative for preventing and controlling its spread. In this study, the multiangle cano...; 关键词：Characteristic wavelength selection Estimation model Machine learning Multi-angular remote sensing Wheat powdery mildew

Siberian Fan Reliefs and the Tunguska Cosmic Body被引量：2: 《Natural Science》2021年第12期510-517,共8页Valery V. Burmakin Alexander Yastrebov; Unusual reliefs on the Earth’s surface were found in aerial photographs of Eastern Siberia in the late 20^th century. The ...; 关键词：Siberian Fan Reliefs Tunguska Catastrophe Tunguska Cosmic Body

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