云南高校图书馆联盟文献共享服务平台- NHEJ

NHEJ: 作品数：42被引量：65H指数：4; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：杨志伟孙永森闫娜娜陈子兴傅松滨更多>>; 相关机构：苏州大学苏州金唯智生物科技有限公司西北农林科技大学中国科学院更多>>; 相关期刊：《National Science Review》《Biophysics Reports》《中国老年学杂志》《Frontiers of Medicine》更多>>; 相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划北京市教委科技发展计划更多>>

Single-molecule techniques in studying the molecular mechanisms of DNA synapsis in non-homologous end-joining repair: 《Biophysics Reports》2025年第1期46-55,共10页Yuhao Jiang Chao Zhao Chenyang Zhang Weilin Li Di Liu Bailin Zhao; supported by the National Natural Science Foundation of China(22104120);the Three Qin Talents Introduction Program for Youths of Shaanxi Province(2023SYJ26);the Fundamental Research Funds for the Central Universities(xtr052023008);the“Young Talent Support Plan”of Xi’an Jiaotong University to Bailin Zhao;by the National Natural Science Foundation of China(32400427);the China Postdoctoral Science Foundation(2022M712546);the Fundamental Research Funds for the Central Universities(xzy012023018);the Postdoctoral Research Project of Shaanxi Province(2023BSHEDZZ07)to Di Liu;by the Fundamental Research Funds for the Central Universities(xzy022024035)to Chenyang Zhang。; DNA double-strand breaks(DSBs)are the most severe form of DNA damage,primarily repaired by the non-homologous end joining(NHEJ)pathway.A critical step in this process is DNA synapsis,where the two broken ends are brou...; 关键词：Single-molecule techniques smFRET Magnetic tweezers Non-homologous end joining(NHEJ) DNA Synapsis

DNA损伤修复通路因子53BP1的功能: 《解剖科学进展》2025年第1期144-148,共5页尤放曹流王美莲; 国家自然科学基金(81770001)。; DNA损伤应答(DNA damage response, DDR)在生命体遗传稳定性(尤其是DNA序列完整性)的维持中扮演着核心角色。53BP1作为该信号通路的关键效应因子,在DNA损伤发生后迅速被募集至损伤部位,对于控制DSBs修复、促进NHEJ、抑制HDR所需的5′端...; 关键词：DNA损伤应答 DSBs修复 NHEJ HDR DNA损伤修复

Genes and proteins expressed at different life cycle stages in the model protist Euplotes vannus revealed by both transcriptomic and proteomic approaches: 《Science China(Life Sciences)》2025年第1期232-248,共17页Yaohan Jiang Xiao Chen Chundi Wang Liping Lyu Saleh A.Al-Farraj Naomi A.Stover Feng Gao; supported by the Science&Technology Innovation Project of Laoshan Laboratory(LSKJ202203202);the National Natural Science Foundation of China(31922013,32270539);Natural Science Foundation of Shandong Province(ZR2020JQ13);Fundamental Research Funds for the Central Universities(202141004);the Researchers Supporting Project(RSP2024R7)King Saud University,Riyadh,Saudi Arabia.; Sexual reproduction first appeared in unicellular protists and has continued to be an essential biological process in almost all eukaryotes.Ciliated protists, which contain both germline and somatic genomes within a s...; 关键词：sexual reproduction TRANSCRIPTOMIC PROTEOMIC genome rearrangement PIWI NHEJ

A highly efficient method for genomic deletion across diverse lengths in thermophilic Parageobacillus thermoglucosidasius: 《Synthetic and Systems Biotechnology》2024年第4期658-666,共9页Zhiheng Yang Bixiao Li Ruihong Bu Zhengduo Wang Zhenguo Xin Zilong Li Lixin Zhang Weishan Wang; supported by the National Key Research and Development Program of China(2020YFA0907800);the National Natural Science Foundation of China(32170095 and 32100066);the Youth Innovation Promotion Association CAS(Y202027)to W.W.; Parageobacillus thermoglucosidasius is emerging as a highly promising thermophilic organism for metabolic engineering.The utilization of CRISPR-Cas technologies has facilitated programmable genetic manipulation in P.t...; 关键词：Type I CRISPR system Thermostable NHEJ enzymes THERMOPHILE Long-range genomic deletions

Epigenetic silencing of BEND4,a novel DNA damage repair gene,is a synthetic lethal marker for ATM inhibitor in pancreatic cancer被引量：1: 《Frontiers of Medicine》2024年第4期721-734,共14页Yuanxin Yao Honghui Lv Meiying Zhang Yuan Li James G.Herman Malcolm V.Brock Aiai Gao Qian Wang Francois Fuks Lirong Zhang Mingzhou Guo; supported by grants from the National Key Research and Development Program of China(Nos.2018YFA0208902 and 2020YFC2002705);the National Natural Science Foundation of China(Nos.82272632 and 81672138);Beijing Science Foundation of China(No.7171008)。; Synthetic lethality is a novel model for cancer therapy.To understand the function and mechanism of BEN domain-containing protein 4(BEND4)in pancreatic cancer,eight cell lines and a total of 492 cases of pancreatic ne...; 关键词：BEND4 DNA methylation synthetic lethality NHEJ pathway

DNA-PKcs在DNA损伤修复中的作用及机制被引量：1: 《中国老年学杂志》2024年第5期1276-1279,共4页李炜娟梁斌黄雄峰李亮荣; 国家自然科学基金资助项目(81160342);江西省自然科学基金资助项目(20122BAB205047);江西省教育厅科技研究重点项目(GJJ208902);江西省教育厅科技研究项目(GJJ11312);抚州市科技计划项目(抚科计字[2015]13号);南昌大学抚州医学院校级科技项目(fykj202204)。; 机体在体内因素如DNA碱基错配、自身不稳定性、机体代谢产生活性氧自由基(ROS)等,体外因素如辐射、化学毒物、药物、病毒和霉菌等作用下,可以造成DNA损伤。DNA损伤有碱基损伤、错配、DNA单链或双链断裂、嘧啶二聚体形成等多种类型。其中...; 关键词：DNA损伤修复 DNA依赖性蛋白激酶亚单位(DNA-PKcs) 非同源末端连接(NHEJ) 抑制剂

CA-NHEJ系统对大肠杆菌链霉素耐药基因rpsL的编辑效率及其耐药性研究: 《江苏农业科学》2023年第23期17-21,共5页谢钰珍覃鸿妮吴凡胡杨晓然薛高旭赵雪张勇; 国家自然科学基金面上项目(编号:22077092);江苏省精准诊疗药物创制工程研究中心(苏州大学)开放课题(编号:SDGC2239);2022年江苏省高校“青蓝工程”资助项目。; 以控制质粒拷贝数的pcnB基因与链霉素耐药性rpsL基因为靶标基因,研究CA-NHEJ系统对大肠杆菌的基因编辑效率,及rpsL相关基因与链霉素耐药性的关系。通过CA-NHEJ系统成功实现了对大肠杆菌MG1655的pcnB和rpsL基因编辑,其中,pcnB基因编辑效...; 关键词：CA-NHEJ系统 CA-HR系统 RPSL基因耐药性

The biological principles and advanced applications of DSB repair in CRISPR-mediated yeast genome editing被引量：1: 《Synthetic and Systems Biotechnology》2023年第4期584-596,共13页Wenxin Bai Meilan Huang Chun Li Jun Li; supported by the National Key Research and Development Program of China(No.2021YFC2101203);the General project of National Natural Science Foundation of China(No.22078021).; To improve the performance of yeast cell factories for industrial production,extensive CRISPR-mediated genome editing systems have been applied by artificially creating double-strand breaks(DSBs)to introduce mutations...; 关键词：Yeast genome editing CRISPR Double-strand break(DSB) Homologous recombination(HR) Nonhomologous end joining(NHEJ) Illegitimate recombination(IR)

ZNF451通过调控53BP1/MDC1促进A549和HeLa细胞DNA损伤修复被引量：2: 《中华放射医学与防护杂志》2022年第4期248-255,共8页夏琪赵国平吴李君; 国家自然科学基金(Y99JZ12502)。; 目的探究SUMO E3连接酶(zinc finger protein 451,ZNF451)介导非小细胞肺癌A549细胞和宫颈癌HeLa细胞DNA损伤修复的功能及机制。方法采用γ射线或依托泊苷处理A549细胞和HeLa细胞,CCK-8法检测细胞增殖活力,蛋白免疫印迹法检测蛋白表达量...; 关键词：ZNF451 DNA损伤修复放疗敏感性 NHEJ 53BP1/MDC1

沉默NHEJ修复通路中关键蛋白Ku70在牙髓干细胞增殖和凋亡中的作用及其机制研究: 《现代生物医学进展》2021年第5期819-824,共6页林红杰王迪叶艳艳熊宇税桦桦黄文静丁大莲谭力芯; 教育部留学回国人员科研启动基金项目(HG2015-002);院级军科基金项目(SWH2016JSTSYB-40N)。; 目的:研究沉默非同源重组修复(non-homologous endjoining,NHEJ)通路中关键蛋白Ku70在牙髓干细胞增殖和凋亡中的作用,分析其机制。方法:提取健康恒牙牙髓组织,进行牙髓干细胞培养。采用脂多糖诱导人牙髓干细胞,分为对照组、阴性对照组...; 关键词：非同源重组修复通路 KU70 牙髓干细胞

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