supported by the National Natural Science Foundation of China(31271547);the Natural Science Foundation of Tianjin,China(14JYBJC23600);the National Key Basic Research and Development Program of China(2010CB833603);the Program for New Century Excellent Talents(NCET-13-0293);the 111 Project Grant(B08011);the Funds for National Basic Science Personnel Training(J1103503)
Non-coding RNAs(nc RNAs),such as micro RNAs and large intergenic non-coding RNAs,have been shown to play essential roles in regulating pluripotency.Yet,it is not clear the role of natural antisense transcripts(NATs),a...
supported by the grants from the Ministry of Science and Technology of China(No.2011CBA01101 to X.-J.W.);the Chinese Academy of Sciences(Nos. XDA01020105,KSCX2-EW-R-01-03 and 2010-Biols-CAS- 0303 to X.-J.W.)
Oct4 is one of the key pluripotent factors essential for embryonic stem cells and induced pluripotent stem (iPS) cells. Oct4 belongs to the POU domain family, which contains multiples genes with various important fu...
supported by the Ministry of Science and Technology of China(Nos.2010CB944900 and 2011CB964800)
Embryonic stem (ES) cells derived from the pre-implantation blastocyst-stage embryos have been widely used to investigate the molecular events determining pluripotency and cell lineage differentiation. As the first ...
supported by the National Basic Research Program of China (973 Program) (No 2006CB943601);the National Natural Science Foundation of China (NSFC) (No 90919042)
OCT4 is one of the key transcription factors in maintaining the pluripotency and self-renewal of embryonic stem (ES) cells.Human OCT4 can generate two isoforms OCT4A and OCT4B by alternative splicing.OCT4B1 is a rec...