PANITUMUMAB

作品数：28被引量：49H指数：4
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相关领域：医药卫生更多>>
相关作者：李龙芸缪若羽王晶孟志云付守廷更多>>
相关机构：北京协和医院北京大学沈阳药科大学军事医学科学院更多>>
相关期刊：《中国癌症杂志》《中国实验血液学杂志》《Journal of Cancer Therapy》《Quantitative Biology》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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In silico designing and optimization of anti-epidermal growth factor receptor scaffolds by complementary-determining regions-grafting technique
《Quantitative Biology》2024年第3期301-312,共12页Razieh Rezaei Adriani Seyed Latif Mousavi Gargari Hamid Bakherad Jafar Amani 
Monoclonal antibodies are attractive therapeutic agents in a wide range of human disorders that bind specifically to their target through their complementary-determining regions(CDRs).Small proteins with structurally ...
关键词：CDR grafting technique EGFR molecular dynamic simulation PANITUMUMAB 
Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report
《World Journal of Gastrointestinal Oncology》2024年第2期557-562,共6页Toshiaki Tsurui Yuya Hirasawa Yutaro Kubota Kiyoshi Yoshimura Takuya Tsunoda 
BACKGROUND Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer(CRC).Effective drainage is often im-possible before initiating systemic chemotherapy,ow...
关键词：Colorectal neoplasms PANITUMUMAB Chemotherapy HYPERBILIRUBINEMIA JAUNDICE Case report 
Liquid biopsy to detect resistance mutations against anti-epidermal growth factor receptor therapy in metastatic colorectal cancer被引量：2
《World Journal of Gastrointestinal Oncology》2022年第9期1654-1664,共11页Guillermo Valenzuela Mauricio Burotto Katherine Marcelain Jaime Gonzalez-Montero 
Supported by Agencia Nacional de Investigación y Desarrollo de Chile,Fondo Nacional de Investigación en Salud (FONIS),No. SA20I0059。
Colorectal cancer(CRC) is a major cause of mortality worldwide, associated with a steadily growing prevalence. Notably, the identification of KRAS, NRAS, and BRAF mutations has markedly improved targeted CRC therapy b...
关键词：Colorectal neoplasms Precision medicine Liquid biopsy CETUXIMAB PANITUMUMAB 
Anti-EGFR therapy in metastatic colorectal cancer:mechanisms and potential regimens of drug resistance被引量：14
《Gastroenterology Report》2020年第3期179-191,I0001,共14页Qing-Hai Li Ying-Zhao Wang Jian Tu Chu-Wei Liu Yu-Jie Yuan Run Lin Wei-Ling He Shi-Rong Cai Yu-Long He Jin-Ning Ye 
supported by the National Natural Science Foundation of China[81871994 and 81701834];the Guangdong Natural Science Foundation[2019B151502063];the Guangdong Science and Technology Planning Program[20190202018].
Cetuximab and panitumumab,as the highly effective antibodies targeting epidermal growth factor receptor(EGFR),have clinical activity in the patients with metastatic colorectal cancer(mCRC).These agents have good curat...
关键词：metastatic colorectal cancer EGFR drug resistance CETUXIMAB PANITUMUMAB 
Management of skin toxicities during panitumumab treatment in metastatic colorectal cancer
《World Journal of Gastroenterology》2019年第29期4007-4018,共12页Olivier Bouche Meher Ben Abdelghani Jean-Luc Labourey Simon Triby René-Jean Bensadoun Thomas Jouary Gaétan Des Guetz 
Amgen 20090656POPEC
BACKGROUND Anti-epidermal growth factor receptor therapy is associated with skin adverse events not previously reported with conventional chemotherapy. Prophylactic actions are recommended, but routine clinical manage...
关键词：Metastatic colorectal cancer Epidermal growth factor receptor inhibitors PANITUMUMAB Skin toxicity Quality of life 
Natural killer cells activity in a metastatic colorectal cancer patient with complete and long lasting response to therapy被引量：1
《World Journal of Clinical Cases》2017年第11期390-396,共7页Alessandro Ottaiano Maria Napolitano Monica Capozzi Salvatore Tafuto Antonio Avallone Stefania Scala 
Here we report a case of a 70-year-old man who received adjuvant chemotherapy with fluorouracile, folinic acid and oxaliplatin after a left hemicolectomy for a stage Ⅲb adenocarcinoma in May 2009. During followup he ...
关键词：COLORECTAL cancer PANITUMUMAB Natural killers REGULATORY cells CHEMOTHERAPY 
Role of targeted therapy in metastatic colorectal cancer被引量：9
《World Journal of Gastrointestinal Oncology》2016年第9期642-655,共14页Yoshihito Ohhara Naoki Fukuda Satoshi Takeuchi Rio Honma Yasushi Shimizu Ichiro Kinoshita Hirotoshi Dosaka-Akita 
Colorectal cancer(CRC) is a significant cause of cancer-related morbidity and mortality all over the world.Improvements of cytotoxic and biologic agents have prolonged the survival in metastatic CRC(mC RC),with a medi...
关键词：METASTATIC colorectal cancer AFLIBERCEPT Ramucirumab REGORAFENIB CETUXIMAB PANITUMUMAB Targeted therapy BEVACIZUMAB 
Second-line panitumumab as a triweekly dose for patients with wild-type KRAS exon 2 metastatic colorectal cancer:a single-institution experience
《Cancer Biology & Medicine》2016年第1期136-141,共6页Mohamed A.Daoud Engy M.Aboelnaga Wael M.Mohamed 
Objective: Panitumumab administered as monotherapy in colorectal cancer(CRC) has shown response and disease stabilization rates of approximately 30%. The current study aimed to evaluate the progression-free survival(P...
关键词：Metastatic colorectal carcinoma panitumumab second-line KRAS 
Cetuximab and panitumumab in a patient with colon cancer and concomitant chronic skin disease:A potential beneficial effect on psoriasis vulgaris被引量：4
《World Journal of Gastroenterology》2015年第12期3746-3749,共4页Ken Okamoto Hiromichi Maeda Takeo Shiga Mai Shiga Ken Dabanaka Kazuhiro Hanazaki Michiya Kobayashi 
Monoclonal antibodies against epidermal growth factor receptor(EGFR) are used in the treatment of advanced colorectal cancer. However, these agents can induce severe dermatological side effects that discourage their a...
关键词：PSORIASIS CETUXIMAB PANITUMUMAB EPIDERMAL growth f 
Advances and new perspectives in the treatment of metastatic colon cancer被引量：2
《World Journal of Gastrointestinal Oncology》2014年第7期211-224,共14页Gonzalo Recondo Jr Enrique Díaz-Cantón Máximo de la Vega Martin Greco Gonzalo Recondo Sr Matias E Valsecchi 
During the last decade we have witnessed an unprec-edented outburst of new treatment approaches for the management of metastatic colon cancer.Anti-angio-genic drugs,epidermal growth factor receptor blockers and multi-...
关键词：Colon Cancer Stage Ⅳ Metastatic Review BEVACIZUMAB CETUXIMAB PANITUMUMAB AFLIBERCEPT REGORAFENIB 
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