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Deciphering 3D periodontal fibroblast-macrophage crosstalk in bioactive nanoparticle-guided immunomodulation for treating traumatic dental avulsion
《Bioactive Materials》2024年第11期400-412,共13页Hadagalu Revana Siddappa Rajeshwari Emily Bishop Aiman Ali Anil Kishen 
American Association of Endodontists Foundation(#1208771);Natural Sciences and Engineering Research Council of Canada(Discovery grant)(AK-RGPIN-2020-05844);Canada Research Chair Program,and Dr.Lloyd and Mrs.Kay Chapman Chairship.
Prolonged extra-oral period in dental avulsion is often associated with loss of viability of Periodontal fibroblasts (PDLF) and increased risk of ankylosis. Root surface treatment with bioactive agents to reduce the r...
关键词：Root resorption Chitosan nanoparticles IMMUNOMODULATION Periodontal fibroblasts Macrophages 
Bioinspired drug-delivery system emulating the natural bone healing cascade for diabetic periodontal bone regeneration被引量：9
《Bioactive Materials》2023年第3期324-339,共16页He Wang Xiaowei Chang Qian Ma Boyang Sun Han Li Jinmin Zhou Yiyao Hu Xiaoyu Yang Jie Li Xin Chen Jinlin Song 
National Natural Science Foundation of China(Grant No.31971282 and 82071072);Chongqing Graduate Tutor Team 2019(dstd201903).
Diabetes mellitus(DM)aggravates periodontitis,resulting in accelerated periodontal bone resorption.Disordered glucose metabolism in DM causes reactive oxygen species(ROS)overproduction resulting in compromised bone he...
关键词：Periodontal bone regeneration Diabetes mellitus BIOINSPIRED HYDROGEL Drug delivery 
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes被引量：14
《Bioactive Materials》2022年第12期213-227,共15页Yazhen Li Lu Yang Yue Hou Zhenzhen Zhang Miao Chen Maoxia Wang Jin Liu Jun Wang Zhihe Zhao Chaoming Xie Xiong Lu 
grants from Sichuan Key Research and Development Program of China(22ZDYF2034);National Natural Science Foundation of China(grant no.82072071,82072073);Key-Area Research and Development Program of Guang Dong Province(2019B010941002);Shenzhen Funds of the Central Government to Guide Local Scientific and Technological Development(2021SZVUP123);Sichuan Science and Technology Program(2020YFS0170);Fundamental Research Funds for the Central Universities(2682020ZT79);Guangdong Basic and Applied Basic Research Foundation(2021B1515120019);Research and Develop Program,West China Hospital of Stomatology Sichuan University(RD-03-202012,RD-03-202101).
Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great challenge.Here,a polydopamine-mediated graphene oxide(PGO)and hydroxyapatite nanop...
关键词：POLYDOPAMINE Graphene oxide Conductive scaffold ROS-Scavenging Macrophage polarization 
L-cysteine-modified chiral gold nanoparticles promote periodontal tissue regeneration被引量：1
《Bioactive Materials》2021年第10期3288-3299,共12页Shuang Zhang Hong Zhou Na Kong Zezheng Wang Huangmei Fu Yangheng Zhang Yin Xiao Wenrong Yang Fuhua Yan 
This work was supported by The National Natural Science Foundation Project[grant numbers 81771078,81570982,21675074,21675075];Jiangsu Provincial Medical Innovation Team,The Project of Invigorating Health Care through Science,Technology and Education[grant number CXTDB2017014];the Nanjing Clinical Research Center for Oral Diseases[grant number 2019060009];The Natural Science Foundation of Shandong Province(ZR2018ZC0231).
Gold nanoparticles(AuNPs)with surface-anchored molecules present tremendous potential in tissue regeneration.However,little is known about chiral-modified AuNPs.In this study,we successfully prepared L/D-cysteine-anch...
关键词：CHIRALITY Gold nanoparticles PERIODONTAL Tissue regeneration AUTOPHAGY 
Recent advances in periodontal regeneration: A biomaterial perspective被引量：26
《Bioactive Materials》2020年第2期297-308,共12页Yongxi Liang Xianghong Luan Xiaohua Liu 
supported by NIH/NIDCR(DE024979,DE019463).
Periodontal disease(PD)is one of the most common inflammatory oral diseases,affecting approximately 47%of adults aged 30 years or older in the United States.If not treated properly,PD leads to degradation of periodont...
关键词：PERIODONTAL eventually PROPERLY 
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