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Dual-engineered cartilage-targeting extracellular vesicles derived from mesenchymal stem cells enhance osteoarthritis treatment via miR-223/NLRP3/pyroptosis axis:Toward a precision therapy被引量：1
《Bioactive Materials》2023年第12期169-183,共15页Weixuan Liu Anqi Liu Xujun Li Ziyang Sun Zhenghua Sun Yaru Liu Gang Wang Dan Huang Hao Xiong Shiyang Yu Xintao Zhang Cunyi Fan 
the Key Project of National Natural Science Foundation of China(81830076);the National Natural Science Foundation of China(82272568);the Shanghai Engineering Technology Research Center and Professional Technology Service Platform project of 2020“Science and Technology Innovation Action Plan”of Shanghai(20DZ2254100);the Biomedical Technology Support Special Project of Shanghai 2021“Science and Technology Innovation Action Plan”(21S31902300).
Osteoarthritis(OA)is the most common disabling joint disease with no effective disease modifying drugs.Extracellular vesicles released by several types of mesenchymal stem cells could promote cartilage repair and amel...
关键词：OSTEOARTHRITIS Extracellular vesicles NLRP3 inflammasome PYROPTOSIS Cartilage-targeting 
Intrinsically bioactive and biomimetic nanoparticle-derived therapies alleviate asthma by regulating multiple pathological cells被引量：2
《Bioactive Materials》2023年第10期12-26,共15页Jiajun Cai Hui Tao Huan Liu Yi Hu Songling Han Wendan Pu Lanlan Li Gang Li Chenwen Li Jianxiang Zhang 
supported by the National Natural Science Foundation of China(Nos.81971727 and 32271451);the Program for Scientific and Technological Innovation Leader of Chongqing(No.CQYC20210302362);the Program for Distinguished Young Scholars of TMMU,and the Graduate Supervisor Team Program of Chongqing in 2022.
Asthma is a serious global public health concern. Airway neutrophilic inflammation is closely related to severe asthma, for which effective and safe therapies remain to be developed. Here we report nanotherapies capab...
关键词：Neutrophilic asthma Nanotherapy Neutrophil extracellular traps INFLAMMASOME Precision therapy 
Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer被引量：2
《Bioactive Materials》2022年第5期1-14,共14页Jialun Duan Chunjie Bao Ying Xie Haitao Guo Yixuan Liu Jianwei Li Rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling Wang Wanliang Lu 
supported by the Natural Science Foundation of Beijing Municipality(Key Grant No.7181004);the National Natural Science Foundation of China(No.81874303).
Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast cancer.However,how to efficiently deliver the CRISPR syst...
关键词：Core-shell nanoparticles Non-viral gene delivery Precise gene editing CTCF Metastatic breast cancer 
Development of a novel RNAi therapy:Engineered miR-31 exosomes promoted the healing of diabetic wounds被引量：8
《Bioactive Materials》2021年第9期2841-2853,共13页Jinghuan Huang Muyu Yu Wenjing Yin Bo Liang Ang Li Jingfeng Li Xiaolin Li Shichang Zhao Fang Liu 
The authors acknowledge the support of the National Natural Science Foundation of China(81572178,81270397,81702317,81871752 and 81770802);the National Key R&D Program of China(2017YFC1309601 to Fang Liu);Shanghai Municipal Commission of Health and Family Planning under the fund(20124356);a Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant(20152232).
Rationale:Chronic wounds associated with diabetes exact a heavy burden on individuals and society and do not have a specific treatment.Exosome therapy is an extension of stem cell therapy,and RNA interference(RNAi)-ba...
关键词：Engineered exosomes Diabetes chronic wounds RNAi therapy miR-31-5p Precision therapy 
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