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m6A reader YTHDF2 governs the onset of atrial fibrillation by modulating Cacna1c translation
《Science China(Life Sciences)》2025年第3期706-721,共16页Chuansheng Chen Guanghua Wang Qicheng Zou Ke Xiong Zhiwen Chen Beihua Shao Yi Liu Duanyang Xie Yong Ji 
supported by the National Natural Science Foundation of China(82121001,82222008,82070338,82470330);the Fundamental Research Funds for the Central Universities.
Atrial fibrillation(AF)is the most common arrhythmia,which is tightly associated with the abnormal expression and function of ion channels in the atrial cardiomyocytes.N^(6)-methyladenosine(m^(6)A),a widespread chemic...
关键词：YTHDF2 atrial fibrillation Cacna1c translation action potential duration effective refractory period 
Reading m^(6)A marks in mRNA:A potent mechanism of gene regulation in plants
《Journal of Integrative Plant Biology》2024年第12期2586-2599,共14页Thi Kim Hang Nguyen Hunseung Kang 
supported by a grant from the Mid-Career Re-searcher Program through the National Research Foundation of Korea funded by the Ministry of Science,ICT and Future Planning(NRF-2021R1A2C1004187),Republic of Korea.
Modifications to RNA have recently been recognized as a pivotal regulator of gene expression in living organisms.More than 170 chemical modifications have been identified in RNAs,with N6-methyladenosine(m^(6)A)being t...
关键词：epitranscriptomics m^(6)A modification m^(6)A reader RNA metabolism YTH 
Selective recognition of PTRE1 transcripts mediated by protein-protein interaction between the m^(6)A reader ECT2 and PTRE1
《Plant Communications》2024年第11期144-156,共13页Li Yang Bo Wang Duanmu Zhao Xuechun Li Yifei Qin Ning Ouyang Zhili Xiao Zhibing Zhang Gad Galili Jiayang Li Hadas Peled-Zehavi Jian Wu 
Double first-class discipline promotion project(2021B10564001);Laboratory of Lingnan Modern Agriculture Project(NT2021001 and NG2021004).
N^(6)-methyladenosine (m^(6)A) is a prevalent internal post-transcriptional modification in eukaryotic RNAs executed by m^(6)A-binding proteins known as “readers.” Our previous research demonstrated that the Arabido...
关键词：ECT2 20S proteasome m^(6)A RNA protein interaction ARABIDOPSIS 
Epigenetic reader ZMYND11 noncanonical function restricts HNRNPA1-mediated stress granule formation and oncogenic activity被引量：1
《Signal Transduction and Targeted Therapy》2024年第10期4708-4729,共22页Cheng Lian Chunyi Zhang Pan Tian Qilong Tan Yu Wei Zixian Wang Qin Zhang Qixiang Zhang Mengjie Zhong Li-Quan Zhou Xisong Ke Huabing Zhang Yao Zhu Zhenfei Li Jingdong Cheng Gong-Hong Wei 
National Key Research and Development Program of China(2022YFC2703600);National Natural Science Foundation of China(82073082,82311530050,81772948,81972617);Shanghai Interactional Collaborative Project(23410713300);Key Research and Development Program of Anhui Province(2022i01020023)。
Epigenetic readers frequently affect gene regulation,correlate with disease prognosis,and hold significant potential as therapeutic targets for cancer.Zinc finger MYND-type containing 11(ZMYND11)is notably recognized ...
关键词：INVASION thereby stress 
ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader
《Protein & Cell》2024年第7期493-511,共19页Chuanle Wang Yan Huang Yue Yang Ruofei Li Yingying Li Hongxin Qiu Jiali Wu Guang Shi Wenbin Ma Zhou Songyang 
National Natural Science Foundation(Grant Nos.82271598,81871109,82071587,31930058,32330023 and 32170757);National Key Research and Development Program of China(2018YFA0107003);Guang Dong Basic and Applied Basic Research Foundation(2020A1515010462).
Telomeres are specialized structures at the ends of linear chromosomes that protect genome stability.The telomeric repeat-containing RNA(TERRA)that is transcribed from subtelomeric regions can invade into double-stran...
关键词：ILF3 RNA:DNA hybrids telomeric R-loops homologous recombination telomeric DNA damage responses 
m^(6)A reader YTHDF1 promotes cardiac fibrosis by enhancing AXL translation
《Frontiers of Medicine》2024年第3期499-515,共17页Han Wu Weitao Jiang Ping Pang Wei Si Xue Kong Xinyue Zhang Yuting Xiong Chunlei Wang Feng Zhang Jinglun Song Yang Yang Linghua Zeng Kuiwu Liu Yingqiong Jia Zhuo Wang Jiaming Ju Hongtao Diao Yu Bian Baofeng Yang 
funded by the National Natural Science Foundation of China(Nos.82104168 and U21A20339);the China Postdoctoral Science Foundation(Nos.2021M693832);Heilongjiang Province Postdoctoral Science Foundation(No.LBH-Z20174).
Cardiac fibrosis caused by ventricular remodeling and dysfunction such as post-myocardial infarction(MI)can lead to heart failure.RNA N6-methyladenosine(m^(6)A)methylation has been shown to play a pivotal role in the ...
关键词：cardiac fibrosis YTHDF1 AXL ZBED6 heart failure 
Phase separation of SPIN1 through its IDR facilitates histone methylation readout and tumorigenesis
《Journal of Molecular Cell Biology》2024年第6期28-42,共15页Yukun Wang Yuhan Chen Mengyao Li Jiayue Wang Yuhan Jiang Rong Xie Yifeng Zhang Zhihua Li Zhenzhen Yan Chen Wu 
National Natural Science Foundation of China(32071277);Science and Technology Program of Hebei Province(216Z2602G);Natural Science Foundation of Hebei Province(C2021201012);Interdisciplinary Research Program of Natural Science of Hebei University(DXK202006).
Spindlin1(SPIN1)is a unique multivalent histone modification reader that plays a role in ribosomal RNA transcription,chromosome segregation,and tumorigenesis.However,the function of the extended N-terminal region of S...
关键词：SPIN1 IDR phase separation histone methylation reader TUMORIGENESIS 
Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)
《Oncology Research》2024年第3期503-515,共13页XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG 
the Chinese Scholarship Council(Grant No.202206240086);the National Natural Science Foundation of China(Grant No.82170432);programs from Science and Technology Department of Sichuan Province(Grant No.2020YFSY0024).
The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer ...
关键词：Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects 
The RNA binding protein EHD6 recruits the m^(6)A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering被引量：2
《Molecular Plant》2024年第6期935-954,共20页Song Cui Peizhe Song Chaolong Wang Saihua Chen Benyuan Hao Zhuang Xu Liang Cai Xu Chen Shanshan Zhu Xiangchao Gan Hui Dong Yuan Hu Liang Zhou Haigang Hou Yunlu Tian Xi Liu Liangming Chen Shijia Liu Ling Jiang Haiyang Wang Guifang Jia Shirong Zhou Jianmin Wan 
supported by the Key Laboratory of Biology,Genetics and Breeding of Japonica Rice in Mid-lower Yangtze River,Ministry of Agriculture and Rural Affairs,China,and the Jiangsu Collaborative Innovation Center for Modern Crop Production,China.Funding for this work was provided by the National Key Research and Development Program of China(2020YFE0202300 and 2021YFD1200504);the National Natural Science Foundation of China(31971910 and 32272115);the National Science Foundation of Jiangsu Province(BK20212010 and BK20230038);the Foundation of Biological Breeding Zhongshan Lab(BM2022008-03,ZSBBL-KY2023-04,and ZSBBL-KY2023-06).
N6-Methyladenosine(m^(6)A)is one of the most abundant modifications of eukaryotic mRNA,but its comprehensive biological functionality remains further exploration.In this study,we identified and characterized a new flo...
关键词：N6-methyladenosine m^(6)A EHD6 YTH domain-containing protein phase separation heading date 
An Avid Reader and His Dictionary
《Women of China》2024年第5期7-7,共1页
A dictionary caught the attention of Chinese President Xi Jinping during his visit to the China National Archives of Publications and Culture last June.Versions of the Xinhua Dictionary published in the 1950s and 1960...
关键词：DICTIONARY turned AVID 
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