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Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease
《Neural Regeneration Research》2025年第11期3193-3206,共14页Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou 
supported by Singapore National Medical Research Council(NMRC)grants,including CS-IRG,HLCA2022(to ZDZ),STaR,OF LCG 000207(to EKT);a Clinical Translational Research Programme in Parkinson's Disease;Duke-Duke-NUS collaboration pilot grant(to ZDZ)。
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogene...
关键词：dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches 
Review of Research on Underwater Explosions Related to Ship Damage and Stability
《哈尔滨工程大学学报(英文版)》2025年第2期285-300,共16页Ruiyao Zhang Wei Xiao Xiongliang Yao Xiaochao Zou 
Supported by the Key R&D Program of Heilongjiang Province(Grant No.JD22A024);the Science Fund for Excellent Youth Foundation of Heilongjiang Province of China(Grant No.YQ2021E010).
Researchers have achieved notable advancements over the years in exploring ship damage and stability resulting from underwater explosions(UNDEX).However,numerous challenges and open questions remain in this field.In t...
关键词：Underwater explosion Load characteristics Structural damage STABILITY Non-displacement ships 
Ethnic heterogeneity of juvenile arthritis in the Republic of Sakha(Yakutia)related to a high human leukocyte antigen B27 frequency
《World Journal of Clinical Pediatrics》2025年第2期69-78,共10页Sargylana Boeskorova Marina Afonskaya Vera Argunova Polina Sleptsova Liudmila Leonteva Tatiana Burtseva Mikhail Mikhailovich Kostik 
BACKGROUND Prevalence of the main rheumatic diseases in the Republic of Sakha(Yakutia)[RS(Y)],one of the regions of the Russian Federation,differs from the other regions of the Russian Federation due to its ethnic and...
关键词：Juvenile idiopathic arthritis Human leukocyte antigen B27 Seronegative spondyloarthritis Enthesitis-related arthritis Epidemiology ARTHRITIS YAKUTIA Sakha Human leukocyte antigen B27-associated arthritis Ethnic variation 
Logistic regression analysis of pathological features of bone metastasis in colorectal cancer and related influencing factors after surgery
《World Journal of Gastrointestinal Surgery》2025年第4期31-37,共7页Qiu-Yan Tang Wei Yu 
BACKGROUND Colorectal cancer(CRC)is a common malignant tumor in the digestive system,whose main treatment comprises surgical resection,radiotherapy and chemotherapy,and targeted drug therapy.At present,the radical res...
关键词：Colorectal cancer Bone metastasis Pathological characteristics Influencing factors Clinic treatment 
The effect of long-term administration of green tea catechins on aging-related cardiac diastolic dysfunction and decline of troponin I
《Genes & Diseases》2025年第2期337-349,共13页Junjun Quan Zhongli Jia Lingjuan Liu Jie Tian 
supported by grants from the Science and Technology Foundation of Chongqing,China (No.cstc2021jcyj-bshX0056);the Key Grant from the National Clinical Research Center for Child Health and Disorders (China) (No.NCRCCHD-2021-KP-01);the National Natural Science Foundation of China (No.81974030);the National Key Clinical Specialty (China).
Aging is an independent risk factor for cardiovascular diseases.Cardiac diastolic dysfunction(CDD),ultimately leading to heart failure with preserved ejection fraction(HFpEF),is prevalent among older individuals.Altho...
关键词：AGING Cardiac diastolic dysfunction Cardiac troponin I Epigallocatechin gallate Histone deacetylase 1 
Rethinking carnitine palmitoyltransferase II and liver stem cells in metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma
《World Journal of Gastroenterology》2025年第15期136-143,共8页Hong Cai Chun-Hui Yang Peng Gao 
This article discusses a recent study by Wang et al that sheds light on the metabolic and immunological mechanisms driving the progression of metabolic dysfunction-associated fatty liver disease(MAFLD)to hepatocellula...
关键词：Metabolic dysfunction-associated fatty liver disease Carnitine palmitoyltransferase II Hepatocellular carcinoma Liver cancer stem cells Mitochondrial dysfunction Metabolic dysfunction 
Machine learning algorithms reveal gut microbiota signatures associated with chronic hepatitis B-related hepatic fibrosis
《World Journal of Gastroenterology》2025年第16期30-48,共19页Ying Zhu Shi-Yu Geng Yao Chen Qing-Jing Ru Yi Zheng Na Jiang Fei-Ye Zhu Yong-Sheng Zhang 
Supported by the Zhejiang Provincial Natural Science Foundation,No.LZ22H270001.
BACKGROUND Hepatic fibrosis(HF)represents a pivotal stage in the progression and potential reversal of cirrhosis,underscoring the importance of early identification and therapeutic intervention to modulate disease tra...
关键词：Chronic hepatitis B virus infection Hepatic fibrosis Liver stiffness Fecal microbiomes Serum intestinal mucosal barrier 
Factors related to adversity quotient in junior high school students
《Frontiers of Nursing》2025年第1期19-26,共8页Wanita Kwansumran Jinjutha Chaisena Dallas Sawitree Wonginjun Nattaya Sangsai 
supported by the Faculty of Nursing Burapha University(No.19/2561).
Objectives: To determine the level of adversity quotient and its associations with rumination, optimism, and authoritative parenting style in junior high school students. Adversity quotient is the adaptation ability t...
关键词：adversity quotient authoritative parenting early adolescence OPTIMISM RUMINATION 
Establish and validate an artificial neural networks model used for predicting portal vein thrombosis risk in hepatitis B-related cirrhosis patients
《World Journal of Hepatology》2025年第3期90-101,共12页Pei-Pei Meng Fei-Xiang Xiong Jia-Liang Chen Yang Zhou Xiao-Li Liu Xiao-Min Ji Yu-Yong Jiang Yi-Xin Hou 
Supported by The Beijing Hospitals Authority Youth Programme,No.QMl220201802.
BACKGROUND The portal vein thrombosis(PVT)can exacerbate portal hypertension and lead to complications,increasing the risk of mortality.AIM To evaluate the predictive capacity of artificial neural networks(ANNs)in qua...
关键词：Machine learning Portal vein thrombosis RISK Hepatitis B-related cirrhosis 
Integrative analysis of cuproptosis-related IncRNAs:Unveiling prognostic significance,immune microenvironment,and copper-induced mechanisms in prostate cancer
《Cancer Pathogenesis and Therapy》2025年第1期48-59,共12页Haitao Zhong Yiming Lai Wenhao Ouyang Yunfang Yu Yongxin Wu Xinxin He Lexiang Zeng Xueen Qiu Peixian Chen Lingfeng Li Jie Zhou Tianlong Luo Hai Huang 
supported by grants from the National Natural Science Foundation of China(Nos.82372912,81802527,81972471,82073408,81974395,and 82173036);National Key Research and Development Program of China(Nos.2022YFC3602900 and 2022YFC3602904);BeijingBethune CharitableFoundation(Nos.mnzl202001 and mnzl202026);Guangzhou Science and Technology Project(Nos.202206010078 and 202201020574);Sun Yat-sen University Clinical Research 5010 Program(Nos.2018007 and 2019005);Sun Yat-sen Clinical Research Cultivating Program(No.SYS-C-201801);Guangdong Medical Science and Technology Program(No.A2020558);Tencent Charity Foundation(No.7670020025);Scientific Research Launch Project of Sun Yat-sen Memorial Hospital(No.YXQH202209);GuangdongBasicand AppliedBasicResearchFoundation(No.2019A1515011437);International Science and Technology Cooperation Project Plan of Guangdong Province(No.2021A0505030085);Guangzhou Science and Technology Key R&D Project(No.202206010117);Beijing CSCO Clinical Oncology Research Foundation(No.Y-tongshu2021/ms-0162);Guangdong Provincial Clinical Research Center for Urological Diseases(No.2020B1111170006);Guangdong Science and Technology Department(No.2020B1212060018);open research funds from the Sixth Affiliated Hospital of Guangzhou Medical University,Qingyuan People's Hospital.
Background:Long non-coding ribonucleic acids(lncRNAs)regulate messenger RNA(mRNA)expression and influence cancer development and progression.Cuproptosis,a newly discovered form of cell death,plays an important role in...
关键词：Prostate cancer Cuproptosis Deep learning IncRNAs 
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