SHIGELLA

作品数：48被引量：85H指数：5
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相关领域：医药卫生更多>>
相关作者：顾兵郝柏林赵丽华周勇万成松更多>>
相关机构：锦州医科大学复旦大学南京医科大学南方医科大学更多>>
相关期刊：《Journal of Animal Science and Biotechnology》《Cellular & Molecular Immunology》《Science China(Life Sciences)》《Open Journal of Medical Microbiology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划广东省科技计划工业攻关项目更多>>
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Research progress in Shigella in the postgenomic era被引量：2
《Science China(Life Sciences)》2010年第11期1284-1290,共7页PENG JunPing, YANG Jian & JIN Qi State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology,Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100176, China 
supported by the National Natural Science Foundation of China (Grant No. 30700033);National Basic Research Program of China (Grant Nos. 2009CB522603 and 2005CB522904)
Gram-negative,facultative intracellular anaerobes of the genus Shigella,the principal etiologic agents of shigellosis,continue to pose a threat to public health. Shigellosis causes 1.1 million deaths with over 164 mil...
关键词：SHIGELLA GENOMICS TRANSCRIPTOMICS PROTEOMICS structural BIOLOGY 
Construction, detection and microarray analysis on Shigella dysenteriae A1 IroN, ShuA single, double mutants被引量：1
《Science China(Life Sciences)》2006年第3期251-258,共8页BIN Wen, LIU Moqing, PENG Junping, SUN Lilian, XU Xingye, ZHANG Jinghai& JIN Qi Shengyang Pharmaceutical University, School of Pharmaceutical Engineering, Shengyang 110016, China State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China 
In this study, we constructed single mutants MTS-1, MTS-2 of IroN and ShuA gene and double mutant MTS of them in Shigella dysenteriae A1 strain 51197 by insert and absence. The functional detection of every mutant was...
关键词：SHIGELLA dysenteriae A1  gene knockout  functional detection  MICROARRAY analysis. 
Comparison of the virulence plasmid genomes of two strains of Shigella which lost the ability to bind Congo red
《Science China(Life Sciences)》2006年第2期141-148,共8页XIONG Zhaohui1, TANG Xudong1,2, YANG Fan1, ZHANG Xiaobing1, YANG Jian1, CHEN Lihong1, NIE Huan1, YAN Yongliang1, JIANG Yan1, WANG Jing1, XUE Ying1, XU Xingye1, ZHU Yafang1, DONG Jie1, AN Lizhe2, WANG Xunling2 & JIN Qi1 1. State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100052, China 2. School of Life Science, Lanzhou University, Lanzhou, 743000) 
We determined; analyzed the Shigella flexneri serotype 5 (pSF5); S. dysenteriae serotype 1 (pSD1) virulence plasmid genomes. The total length of pSF5 is 136513 bp, including 165 open reading frames (ORFs). Of these OR...
关键词：SHIGELLA flexneir SEROTYPE 5  SHIGELLA dysenteriae SEROTYPE 1  virulence plasmid  CONGO red  genome comparison. 
Construction of a trivalent candidate vaccine against Shigella species with DNA recombination被引量：1
《Science China(Life Sciences)》2002年第1期10-20,共11页王恒樑 廖翔 苏国富 冯尔玲 金明 黄翠芬 林云 黄留玉 
In this work asd gene of Shigella flexneri 2a strain T32 was replaced by Vibrio cholerae toxin B subunit (ctxB) gene with DNA recombination in vivo and in vitro. The resulting derivative of T32, designed as FWL01, cou...
关键词：SHIGELLA spp.  ctxB gene  balanced-lethal system  vaccine. 
Construction of a trivalent candidate Shigella vaccine strain with host-vector balanced-lethal system被引量：2
《Science China(Life Sciences)》1997年第1期52-59,共8页芮贤良 徐永强 吴旭东 苏国富 黄翠芬 
A trivalent live Shigella vaccine candidate FSD01 against S. flexneri 2a, S. sonnei and S. dysen-teriae I was constructed. This candidate strain was based on the S. flexneri 2a vaccine T32. By homologous recombi-natio...
关键词：SHIGELLA spp balanced-lethal SYSTEM RECOMBINANT VACCINE strain immune protection. 
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