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Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer
《Genes & Diseases》2025年第2期98-101,共4页Ruizhi Chang Ganxun Li Guan-nan Jin Bixiang Zhang Ze-yang Ding 
supported by the National Nature Science Foundation of China (No.82273441,81874065);the National Basic Research Program of China (No.2020YFA0710700);the Knowledge Innovation Program of Wuhan-Shuguang Project (China) (No.2022020801020456);Tongji Hospital (HUST)Foundation for Excellent Young Scientist (China) (No.2020YQ05);the First Level of the Public Health Youth Top Talent Project of Hubei Province (China) (No.2022SCZ051).
Despite the improvement of programmatic screening,adjuvant chemotherapy,and curative resection,colon cancer,with increasing incidence and mortality rates,still poses a significant public health challenge as the third ...
关键词：COLON cancer MORTALITY 
Targeting novel sites represents an effective strategy for combating drug resistance
《Chinese Chemical Letters》2025年第1期3-5,共3页Shaoqing Du Xinyong Liu Xueping Hu Peng Zhan 
Drug resistance poses an escalating global challenge in the battle against infections.The effectiveness of conventional antibiotics and other anti-infective drugs is waning as microbes develop heightened resistance to...
关键词：resistance DRUGS HUMANITY 
SARS-CoV-2 ORF10 hijacking ubiquitination machinery reveals potential unique drug targeting sites
《Acta Pharmaceutica Sinica B》2024年第9期4164-4173,共10页Kaixiang Zhu Lili Song Linyue Wang Lei Hua Ziyu Luo Tongyun Wang Bo Qin Shuofeng Yuan Xiaopan Gao Wenyi Mi Sheng Cui 
the following staff members and grant support.BL19U1 beamline of the National Facility for Protein Science in Shanghai(NFPS),BL17U1 beamline,and BL10U2 beamline at the Shanghai Synchrotron Radiation Facility.We thank the staff of PX III beamline at the Swiss Light Source,PaulScherrer Institute(Villigen Switzerland)for assistance in data collection.We thank the staffs from the Core Facility of National Institute of Pathogen Biology,Chinese Academy of Medical Sciences.This work was supported by National Key Research and Development Program of China(2023YFC2307803);Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2022-I2M-1-021,China);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2023-PT310-04,China);National Natural Science Foundation of China(82341095,82261160398,82072291,82272308);the Fundamental Research Funds for the Central Universities(3332021092,China).
Viruses often manipulate ubiquitination pathways to facilitate their replication and pathogenesis.CUL2ZYG11B known as the substrate receptor of cullin-2 RING E3 ligase,is bound by SARS-CoV-2 ORF10 to increase its E3 l...
关键词：SARS-CoV-2 ORF10 Crystal structure cullin-2 RING E3 ligase Drug design 
Erythrocytes serve as a template to create nanozymes with uniform Fe single-atom sites for healing bacteria-infected wound
《Science China(Life Sciences)》2024年第9期2048-2050,共3页Thinh Viet Dang Moon Il Kim 
supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(Ministry of Science and ICT(NRF-2023R1A2C2007833));the Basic Science Research Program through the NRF funded by the Ministry of Education(2021R1A6A1A03038996)。
Bacterial infection is recognized as one of the biggest global health threats,causing millions of people's death every year(Wang et al.,2020).Traditional antibiotics-based therapies have been widely utilized to contro...
关键词：TEMPLATE HEALING utilized 
Assessment of albendazole efficacy against Ascaris lumbricoides at three sites of Andhra Pradesh,Odisha,and Kerala in India
《Asian Pacific Journal of Tropical Medicine》2024年第7期310-316,共7页Vinay Garg Ankur Garg Shubha Garg Sudhir Kumar Jain Tanzin Dikid Saurabh Jain Jitendra Manjhi Antonio Montresor Atul Goel 
Objective:To assess efficacy of albendazole against Ascaris(A.)lumbricoides among school-children at three sites of Rajahmundry,Sundergarh and Wayanad.Methods:Sites were selected based on soil-transmitted helminths pr...
关键词：Soil transmitted helminths Ascaris lumbricoides ALBENDAZOLE EFFICACY 
Visceral Leishmaniasis at the National Reference University Hospital Center of N’Djamena (Chad): Epidemiological, Clinical, Diagnostic, Therapeutic and Prognostic Aspects
《Advances in Infectious Diseases》2024年第2期478-486,共9页Joseph Mad-Toïngué Mahamat Ali Ahmat Oumaïma Mahamat Djarma Alifa Adjibera Philippe Ali Mahamat Moussa Ngakoutou Rangar Choua Ouchemi Mahamat Ali Bolti Djiddi Ali Sougoudi Mamissou Didi Mahamat Doungous Atim 
Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is...
关键词：Visceral Leishmaniasis Gold Mining Sites CHAD 
Application of sentiment and word frequency analysis of physician review sites to evaluate refractive surgery care
《Advances in Ophthalmology Practice and Research》2024年第2期78-83,共6页Victoria Vought Rita Vought Andrew S.Lee Irene Zhou Mansi Garneni Steven A.Greenstein 
Background:Online physician reviews increase transparency in health care,helping patients make informed de-cisions about their provider.Language processing techniques can quantify this data and allow providers to bett...
关键词：Patient sentiment Quality improvement Physician reviews 
Protein acetylation sites with complex-valued polynomial model
《Frontiers of Computer Science》2024年第3期217-226,共10页Wenzheng BAO Bin YANG 
supported by the National Natural Science Foundation of China(Grant No.61902337);Xuzhou Science and Technology Plan Project(KC21047);Jiangsu Provincial Natural Science Foundation(No.SBK2019040953);Natural Science Fund for Colleges and Universities in Jiangsu Province(No.19KJB520016);Young Talents of Science and Technology in Jiangsu,the Key Research Program of the Science Foundation of Shandong Province(ZR2020KE001);the talent project of“Qingtan Scholar”of Zaozhuang University,the PhD research startup foundation of Zaozhuang University(No.2014BS13);Zaozhuang University Foundation(No.2015YY02).
Protein acetylation refers to a process of adding acetyl groups(CH3CO-)to lysine residues on protein chains.As one of the most commonly used protein post-translational modifications,lysine acetylation plays an importa...
关键词：protein acetylation complex-valued polynomial model machine learning 
Pseudomonas aeruginosa regulator PvrA binds simultaneously to multiple pseudo-palindromic sites for efficient transcription activation
《Science China(Life Sciences)》2024年第5期900-912,共13页Yibo Zhu Bingnan Luo Xingyu Mou Yingjie Song Yonghong Zhou Yongbo Luo Bo Sun Youfu Luo Hong Tang Zhaoming Su Rui Bao 
supported by the Ministry of Science and Technology of China(2022YFC2303700,2021YFA1301900);The National Natural Science Foundation of China(81871615,32222040,32070049);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Action(TSBICIP-KJGG-008);supported in part by a Tibet Science Foundation grant(XZ202001ZY0036 N)to Yonghong Zhou。
Tetracycline repressor(TetR)family regulators(TFRs)are the largest group of DNA-binding transcription factors and are widely distributed in bacteria and archaea.TFRs play vital roles in controlling the expression of v...
关键词：Pseudomonas aeruginosa transcription regulator TetR protein-structure VIRULENCE 
Screening, Treatment and Control of High Blood Pressure on Five Sites in Mali
《World Journal of Cardiovascular Diseases》2024年第5期322-332,共11页Mamadou Touré Sagara Ibrahima Youssouf Camara Hamidou Oumar Bâ Ibrahima Sangaré Djénébou Traoré Noumou Sidibé Fousseyni Samassékou Massama Konaté Coumba Thiam Doumbia Asmaou Maiga Réné-Marie Dakouo Hamidou Camara Sako Mariam Sidibé Samba Adama Sogodogo Boubacar Diarra Boubacar Sonfo Aladji Traoré Mamadou Diakité Ilo Bella Diall Ichaka Menta 
Introduction: High blood pressure is defined as blood pressure greater than or equal to 140 mm Hg for systolic and or 90 mm Hg for diastolic. It constitutes a major public health problem, the leading chronic disease i...
关键词：High Blood Pressure SCREENING Control Rate MALI 
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