By synchronizing the first wave of spermatogenesis, Chen and colleagues profile gene levels and regulation dynamics in 20 stages of sperm development. From this, newfound molecular signatures of sperm maturation are u...
Acknowledgments We are grateful to Xiaole Shirley Liu and Jianhua Yang for thoughtful discussions and valuable comments on the manuscript. This work was supported by grants from the Ministry of Science and Technology of China (2011 CB504605 and 2014AA021103), the National Natural Science Foundation of China (31090253, 31210103912, 31325008 and 91419307), the Chinese Academy of Sciences (CAS; KJZD-EW-L01-2), the Key Laboratory of the Zoological Systematics and Evolution of the Chinese Academy of Sciences (O529YX5105), and the National Science Fund for Fostering Talents in Basic Research (Special subjects in animal taxonomy, NSFC-J1210002). This work was also supported by NIH grants (GM052872 and HG004659). The computing resource was supported by HPC Platform, Scientific Information Center, Institute of Zoology, CAS.
The piRNA machinery is known for its role in mediating epigenetic silencing of transposons. Recent studies suggest that this function also involves piRNA-guided cleavage of transposon-derived transcripts. As many piRN...
Transcriptionally silent sperm contains a variety of RNA frag- ments of both coding and non-coding transcripts. A recent article by Peng and colleagues reveals several new families of small RNAs enriched in sperm, whi...
In the journey from the male to female reproductive tract, mammalian sperm experience a natural osmotic decrease (e.g., in mouse, from ~415 mOsm in the cauda epididymis to -310 mOsm in the uterine cavity). Sperm hav...
supported by foundations from Chinese Academy of Sciences;Special Funds for Major State Basic Research Development program of China(G19990539).
It is well documented that γ-aminobutyric acid (GABA) system existed in reproductive organs. Recent researches showed that GABA_A and GABA_B receptors were present in testis and sperm, and might mediate the acrosome ...
supported by grants from the National Natural Science Foundation of China(No.30130240 and 30070379);the Project of Chinese Academy of Sciences(KSCX2-SW-303);the Frontier Science Projects Program of the Institute of Hydrobiology,Chinese Academy of Sciences(No.220309).
A cell-free system based upon the egg extracts from gynogenetic gibel carp (Carassius auratus gibelio)or bisexual red common carp (Cyprinus carpio red variety) was developed to investigate developmentalbehaviors of th...
supported by the grant from National Key Basic Research Project,“973”(No.G199905592)
Mouse sp56 is considered as one of the candidates for mouse zona pellucida 3 (mZP3) receptor. Up to date, its homologue has only been cloned from guinea pig. namely AM67. Based on the cDNA sequence of mouse sp56, we d...
grants of National "Pan Deng" program; LMCBand National Natural Science FOundation!No: 39770776
Some recent studies indicated that GABAergic system is involved in mammalian sperm acrosome reaction (AR), but direct evidence pertaining to the expression of gat1 in mammalian sperm is not yet demonstrated. In this s...
A cell-free preparation obtained from extracts of activated Xenopus laevis eggs induced chromatin decondensation and nuclear formation from demembranated Xenopus sperm nuclei. Electron microscopy revealed that the rea...