Patients with azoospermia show a prevalence of varicocele of 10.9%and a 14.8%contribution to male infertility.Patients with azoospermia are thought to produce high-quality semen following varicocele treatment.Advising...
supported by the National Natural Science Foundation of China(No.81974226,No.32171264,and No.81974365);the Sichuan Science and Technology Program(No.2021YFS0026 and No.2022YFS0045).
Sperm head morphology is crucial for male factor infertility diagnosis and assessment of male reproductive potential.Severalcriteria are available to analyze sperm head morphology,but they are limited by poor methodol...
This study was supported by the National Natural Science Foundation of China(No.32200485);the University Synergy Innovation Program of Anhui Province(GXXT-2021-071);Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01).
Teratozoospermia with cephalic defects is one of the most severe types of sperm defects known to date.While several monogenic factors are linked to cephalic abnormalities,such as globozoospermia and macrozoospermia,th...
This work was supported by the Central Public Interest Scientific Institution Basal Research Fund of National Research Institute for Family Planning(No.2021GJZ09);the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2018-I2M-1-004)。
MicroRNAs(miRNAs)are mediators of the aging process.The purpose of this work was to analyze the miRNA expression profiles of spermatozoa from men of different ages with normal fertility.Twenty-seven donors were divide...
supported by grants from the National Natural Science Foundation of China(No.81803116 and No.32001072);Open Project Fund from NHC Key Laboratory of Male Reproductive Health/National Research Institute for Family Planning(2022GJP0102);Non-profit Central Research Institute Fund of National Research Institute For Family Planing(2022GJM02);Start-up Fund(Q410800320)from Soochow University.
Approximately 31%of patients with 22q11.2 deletion syndrome(22q11.2DS)have genitourinary system disorders and 6%of them have undescended testes.Haploinsufficiency of genes on chromosome 22q11.2 might contribute to the...
The present study was performed within the framework of the project Multicenter Research Bioresource Collection“Human Reproductive Health”of the Ministry of Science and Higher Education of the Russian Federation(No.15.BRK.21.0008).
We examined a cohort of 93 cystic fibrosis(CF)male patients who were pancreatic-sufficient(PS-CF;n=40)or pancreatic-insufficient(PI-CF;n=53).Complex semen examination was performed,including standard semen analysis,qu...
Advances in the oncology field have led to improved survival rates.Consequently,quality of life after remission is anticipated,which includes the possibility to conceive children.Since cancer treatments are potentiall...
We question whether,in men with an abnormal rate of sperm DNA fragmentation,the magnetic-activated cell sorting(MACS)could select spermatozoa with lower rates of DNA fragmentation as well as spermatozoa with unbalance...
The fatty acid composition of spermatozoa has been shown to be important for their function,and L-carnitine is crucial for fatty acid metabolism.Its levels in the seminal plasma positively correlate with semen quality...
supported by the National Natural Science Foundation of China(No.81801518 and No.82071646).
The present study aimed to evaluate the clinical outcomes of magnetic-activated cell sorting(MACS)in sperm preparation for male subjects with a sperm DNA fragmentation index(DFI)≥30%.A total of 86 patients who had un...