SUMOYLATION

作品数：87被引量：165H指数：7
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相关作者：龚宇彭章龙张简尤圣武廖书胜更多>>
相关机构：中南大学上海交通大学华东师范大学中国科学院大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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Combining radiation and the ATR inhibitor berzosertib activates STING signaling and enhances immunotherapy via inhibiting SHP1 function in colorectal cancer被引量：2
《Cancer Communications》2023年第4期435-454,共20页Chaofan Liu Xi Wang Wan Qin Jingyao Tu Chunya Li Weiheng Zhao Li Ma Bo Liu Hong Qiu Xianglin Yuan 
Innovative Capacity Building Project of the Hubei Engineering Research Center for Radiotherapy and Radiation Protection of Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Grant/Award Number:2018-420114-35-03-071705;State Key Program of National Natural Science of China,Grant/Award Number:82130092;National Natural Science Foundation of China,Grant/Award Numbers:81372664,81902619。
Background:Immune checkpoint inhibitors(ICIs)targeting programmed cell death protein 1(PD-1)and programmed death-ligand 1(PD-L1)have shown a moderate response in colorectal cancer(CRC)with deficient mismatch repair(dM...
关键词：colorectal cancer ATR inhibitor radiotherapy immune checkpoint inhibitor PD-L1 innate immunity cGAS-STING DNA damage SHP1 SUMOYLATION 
SDCBP-AS1 destabilizesβ-catenin by regulating ubiquitination and SUMOylation of hnRNP K to suppress gastric tumorigenicity and metastasis被引量：2
《Cancer Communications》2022年第11期1141-1161,共21页Jing Han Menglin Nie Cong Chen Xiaojing Cheng Ting Guo Longtao Huangfu Xiaomei Li Hong Du Xiaofang Xing Jiafu Ji 
the National High Technology Research and Development Program of China,Grant/Award Number:2014AA020603;Clinical Medicine Plus X-Young Scholars Project of Peking University,Grant/Award Number:PKU2020LCXQ001;the Joint Fund for the Key Projects of National Natural Science Foundation of China,Grant/Award Number:U20A20371;“Double First Class”disciplinary development Foundation of Peking University,Grant/Award Number:BMU2019LCKXJ011;National Natural Science Foundation of China,Grant/Award Numbers:81802471,81872502,81972758,82103528;Beijing Municipal Medical Research Institutes,Grant/Award Number:2019-1;Beijing municipal administration of hospitals’youth program,Grant/Award Number:QML20181102。
Background:Gastric cancer(GC)is among the most malignant tumors,yet the pathogenesis is not fully understood,especially the lack of detailed information about the mechanisms underlying long non-coding RNA(lncRNA)-medi...
关键词：SDCBP2-AS1 gastric cancer hnRNP K Β-CATENIN post-transcriptional modifications tumori-genesis 
Post-translational modification of Parkin and its research progress in cancer被引量：3
《Cancer Communications》2019年第1期655-664,共10页Dan Ding Xiang Ao Ying Liu Yuan-Yong Wang Hong-Ge Fa Meng-Yu Wang Yu-Qi He Jian-Xun Wang 
This work was supported by the National Natural Science Foundation of China(81622005);Beijing Natural Science Foundation(7172213).
Clinical practice has shown that Parkin is the major causative gene found in an autosomal recessive juvenile parkin-sonism(AR-JP)via Parkin mutations and that the Parkin protein is the core expression product of the P...
关键词：PARKIN E3 ubiquitin ligase CANCER Post-translational modification Parkin/PTEN-induced kinase 1(PINK1) NIP3-like protein X UBIQUITINATION SUMOYLATION NEDDYLATION Phosphorylation 
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