supported by the National Natural Science Foundation of China(Nos.81874181,81902361,3213000192,and 91940305);the National Science and Technology Major Projects for“Major New Drug Innovation and Development”(No.2019ZX09301-158);the Shanghai Sailing Program(No.19YF1433000);the Open Project Program of State Key Laboratory of Oncogenes and Related Genes(No.KF2120).
Altered three-dimensional architecture of chromatin influences various genomic regulators and subsequent gene expression in human cancer.However,knowledge of the topological rearrangement of genomic hierarchical layer...