TALE

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Visualization of aging-associated chromatin alterations with an engineered TALE system被引量：5
《Cell Research》2017年第4期483-504,共22页Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu 
We thank Drs Lusheng Gu and Wei Ji and the Center for Bio- logical Instrument Development （CBID）, Institute of Biophysics, Chinese Academy of Sciences （CAS）, for their help in analyzing CLEM images, as well as Shuoguo Li and Center for Biological Imaging （CBI）, Institute of Biophysics, CAS, for technical as- sistance in SIM imaging. We are grateful to Yang Zhao and Lei Bai for administrative assistance. This work was supported by the National Basic Research Program of China （973 Program; 2015CB964800, 2014CB910503 and 2014CB964600）, the Nation- al High Technology Research and Development Program of China （2015AA020307）, CAS （XDA01020312, KJZDEW-TZ-L05, and CXJJ-16M271）, the National Natural Science Foundation of China （NSFC; 81625009, 81330008, 31222039, 81371342, 81300261, 81300677, 81271266, 81471414, 81422017, 81401159, 31671429, 81601233, 81671377, 31601109, and 31601158）, Beijing Natural Science Foundation （7141005 and 5142016）, Pro- gram of Beijing Municipal Science and Technology Commission （Z 151100003915072）, Key Research Program of the Chinese Academy of Sciences （KJZDEW-TZ-L05）, the Thousand Young Talents Program of China, and the State Key Laboratory of Stem Cell and Reproductive Biology （2016SRLabKF13）. TX was sup- ported by NSFC （31127901, 31421002, 81427802, and 31130065） and the Instrument Developing Project of the Chinese Acade- my of Sciences （YZ201443）. ZYJ was supported by the NSFC （81420108017 and 81525010） and the National Basic Research Program of China （973 Program; 2016YFA0100600）. WZ was supported by Youth Innovation Promotion Association of CAS and Early Career Fellowship of Chinese Society of Cell Biology. JQ was supported by the NSFC （31230047） and the National Ba- sic Research Program of China （973 Program; 2014CB943203）. LS was supported by NSFC （81571385）. YY was supported by the Key Special Fund （2016YFC1000601）, the National Basic Research Program of China （973 Program; 2014CB943203） and Beijing Nova
Visualization of specific genomic loci in live cells is a prerequisite for the investigation of dynamic changes in chro- matin architecture during diverse biological processes, such as cellular aging. However, current...
关键词：thioredoxin-fused TALE aging ribosomal DNA repeat TELOMERE CENTROMERE 
TALEN-based generation of a cynomolgus monkey disease model for human microcephaly被引量：13
《Cell Research》2016年第9期1048-1061,共14页Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang 
Acknowledgments This work was supported by the National Basic Research Program of China （2012CBA01302）, the National Natural Science Foundation of China （81425016, 31301219 and 81570593）, the Fundamental Research Funds for the Central Universities （15ykjc01c）, PhD Programs Foundation of Ministry of Education of China （20130171120061）, the Key Scientific and Technological Projects of Guangdong Province （2014B020226002, 2014B020228003, 2014B020225007, 2015B020228002 and 2016B030229002）, Key Scientific and Technological Program of Guangzhou City （201400000003-3, 201508020262, 201300000089 and 2010U 1-E00551）, Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme （GDUPS, 2013） and Pearl River S＆T Nova Program of Guangzhou （2014J2200037）.
Gene editing in non-human primates may lead to valuable models for exploring the etiologies and therapeutic strategies of genetically based neurological disorders in humans. However, a monkey model of neurological dis...
关键词：MCPH1 MICROCEPHALY TALEN gene mutant cynomolgus monkey 
DNA double-strand break repair： a tale of pathway choices被引量：7
《Acta Biochimica et Biophysica Sinica》2016年第7期641-646,共6页Jing Li Xingzhi Xu 
This work was supported by the grants from the National Natural Science Foundation of China （Nos. 31461143012 and 31530016）, the National Basic Research Program of China （Nos. 2013CB911002 and 2015CB910601） to X.X., and from Young Talent Development Plan in Institutions of Higher Learning under the Jurisdiction of Beijing Municipality （No. CIT＆TCD201404158） and Beijing Nova Program Interdisciplinary Cooperation Project to J.L.
Deoxyribonucleic acid double-strand breaks （DSBs） are cytotoxic lesions that must be repaired either through homologous recombination （HR） or non-homologous end-joining （NHEJ） pathways. DSB repair is critical fo...
关键词：DSB 53BP1 RIF1 PTIP BRCA1 
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