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DSB: 作品数：251被引量：439H指数：8; 导出分析报告; 相关领域：政治法律医药卫生更多>>; 相关作者：庄志雄贺小勇蒋奋孙卫国江高峰更多>>; 相关机构：武汉大学华东政法大学浙江大学复旦大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家社会科学基金中国法学会部级法学研究课题国家重点基础研究发展计划更多>>

锅炉燃烧器低负荷超低排放的优化改造被引量：1: 《锅炉技术》2024年第5期8-13,共6页吴家欢李志涛陈雨新何明峰; 国家重点研发计划专项课题(2021YFF0601002)。; 对一种新型低负荷燃烧器(低NO_(x)双分级旋流燃烧器)的结构特点及主要特性进行了介绍;对其在某电厂2×600MW燃煤锅炉机组灵活性改造中的优化改造方案及性能测试结果进行了分析.结果表明:采用该燃烧器可有效解决锅炉在低负荷下的燃烧器...; 关键词：低负荷稳燃性能 DSB低NOx燃烧器火电机组灵活性改造

Exploiting the unique interaction characteristics of fast neutrons for improved cancer therapy:A radiobiological perspective: 《Radiation Medicine and Protection》2024年第1期24-29,共6页Festo Kiragga Konstantin Brazovskiy; Fast neutrons have sufficient energy to liberate recoil protons,alpha particles,and other products when they interact with the nuclei of the target material through scattering and absorption processes.Physical interac...; 关键词：Neutrons Radiation therapy ENERGY Double-strand break(DSB)

The biological principles and advanced applications of DSB repair in CRISPR-mediated yeast genome editing被引量：1: 《Synthetic and Systems Biotechnology》2023年第4期584-596,共13页Wenxin Bai Meilan Huang Chun Li Jun Li; supported by the National Key Research and Development Program of China(No.2021YFC2101203);the General project of National Natural Science Foundation of China(No.22078021).; To improve the performance of yeast cell factories for industrial production,extensive CRISPR-mediated genome editing systems have been applied by artificially creating double-strand breaks(DSBs)to introduce mutations...; 关键词：Yeast genome editing CRISPR Double-strand break(DSB) Homologous recombination(HR) Nonhomologous end joining(NHEJ) Illegitimate recombination(IR)

DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms被引量：2: 《Science China(Life Sciences)》2023年第6期1392-1407,共16页Wei Xu Chao Liu Zhe Zhang Changbin Sun Qin Li Kuan Li Hui Jiang Wei Li Qianwen Sun; supported by the National Natural Science Foundation of China (91740105,31822028,32071437,31900302);Central Public-interest Scientific Institution Basal Research Fund (Y2022QC33)。; Programmed DNA double-strand break(DSB)formation is a crucial step in meiotic recombination,yet techniques for highefficiency and precise mapping of the 3’ends of DSBs are still in their infancy.Here,we report a nove...; 关键词：MEIOSIS DSB DNA break fragile site ENHANCER SPERMATOGENESIS

DsbC介导HCV优势抗原表位原核可溶性表达与间接ELISA分析: 《国际检验医学杂志》2023年第1期63-68,共6页肖彭莹黄国红王丽君孙卫国张灵霞侯江厚; 昆明创新团队项目(2019-1-R-23676);国家科技重大专研项目(2017ZX10201301-007)。; 目的DsbC蛋白与丙型肝炎病毒(HCV)优势抗原表位原核融合表达并纯化,获得一种特异优良的HCV血清抗体诊断抗原。方法通过生物信息学软件,筛选我国HCV主要流行株优势抗原片段并进行串联融合形成组合肽命名为P367,将P367与DsbC蛋白进行融合...; 关键词：丙型肝炎病毒抗原表位筛选 DsbC蛋白间接酶联免疫吸附试验

CRISPR-Cas9技术介导蔬菜作物遗传改良研究进展: 《湖北农业科学》2022年第24期100-109,共10页万丽丽王转茸汤谧张学军曾红霞任俭张娜孙玉宏熊建顺朱志坤; 湖北省重点研发项目(2021BBA101;2022D14015);新疆农业科学院天山创新团队项目(2022D14015);武汉市农业科学院创新项目(XKCX202204-1);武汉市生物育种关键技术及新品种培育重大专项(2022021302024852)。; 在植物中,CRISPR-Cas基因组编辑技术是一种改变基因功能并改良作物品种的新技术。与传统育种相比,CRISPR-Cas是一种操作简单、低成本、高效精准的技术,并且脱靶风险较低。蔬菜作物富含膳食纤维、维生素和矿物质,对人类健康至关重要。然...; 关键词：CRISPR-Cas9 蔬菜双链断裂(DSB) DNA修复精准编辑性状改良

Alternative end-joining in BCR gene rearrangements and translocations被引量：2: 《Acta Biochimica et Biophysica Sinica》2022年第6期782-795,共14页Wanyu Bai Bo Zhao Mingyu Gu Junchao Dong; the grants from the National Natural Science Foundation of China(Nos.,81871304,32070892);Guangdong Innovative and Entrepreneurial Research Team Program(No.,2016ZT06S252);Guangzhou Municipal Science and Technology Bureau(No.,202002030064);the Fundamental Research Funds for the Central Universities(No.,18ykzd11);Sanming Project of Medicine in Shenzhen(No.,SZSM202011004);Open project of Key Laboratory of Tropical Disease Control(Sun,Yat-sen,University);Ministry of Education(No.,2020ZX01)。; Programmed DNA double-strand breaks(DSBs)occur during antigen receptor gene recombination,namely V(D)J recombination in developing B lymphocytes and class switch recombination(CSR)in mature B cells.Repair of these DSB...; 关键词：classical nonhomologous end-joining alternative end-joining V(D)J recombination chromosomal translocation DSB end resection ENDONUCLEASE

CRISPR/Cas9系统诱导DNA断裂的修复机制研究进展被引量：3: 《中国细胞生物学学报》2022年第3期500-511,共12页杨丽芸陈丽娇李善刚; 国家自然科学基金(批准号:31960215)资助的课题。; 近年来,聚类规则间隔的短回文重复序列(clustered regularly interspaced short palindromic repeats,CRISPR)及其相关蛋白(CRISPR-associated protein 9,Cas9)介导的基因编辑技术已广泛应用在生物学、基础医学等研究领域中,通过该技术...; 关键词：CRISPR/Cas9 DSB 同源重组非同源末端连接疾病模型基因治疗

A novel copper-sensing two-component system for inducing Dsb gene expression in bacteria被引量：1: 《Science Bulletin》2022年第2期198-212,M0004,共16页Liang Yu Qiao Cao Weizhong Chen Nana Yang Cai-Guang Yang Quanjiang Ji Min Wu Taeok Bae Lefu Lan; supported by the National Key R&D Program of China(2016YFA0501503);the National Mega-project for Innovative Drugs of China(2019ZX09721001-004-003);the National Natural Science Foundation of China(31670136 31870127 and 81861138047);the Science and Technology Commission of Shanghai Municipality(19JC1416400);the State Key Laboratory of Drug Research(SIMM2003ZZ-03).; In nature, bacteria must sense copper and tightly regulate gene expression to evade copper toxicity. Here,we identify a new copper-responsive two-component system named DsbRS in the important human pathogen Pseudomona...; 关键词：Pseudomonas aeruginosa Two-component system Disulfide bond formation Gene regulation Copper resistance

The molecular control of meiotic double-strand break (DSB) formation and its significance in human infertility被引量：2: 《Asian Journal of Andrology》2021年第6期555-561,共7页Yang Li Yu-Fan Wu Han-Wei Jiang Ranjha Khan Qi-Qi Han Furhan Iqbal Xiao-Hua Jiang Qing-Hua Shi; This work was supported by the National Key Research and Developmental Program of China(2018YFC1003700,2018YFC1003400,and 2016YFC1000600);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB19000000);the National Natural Science Foundation of China(31890780,31630050,32061143006,82071709,and 31871514);the Fundamental Research Funds for the Central Universities(YD2070002006).; Meiosis is an essential step in gametogenesis which is the key process in sexually reproducing organisms as meiotic aberrations may result in infertility. In meiosis, programmed DNA double-strand break (DSB) formation...; 关键词：DNA double-strand break(DSB) INFERTILITY MEIOSIS MUTATION

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