supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education of the Republic of Korea(No.2020R1I1A1A01073545 to E.M.S.,2020R1A2C1010786 to C.M.M.,2021R1A6A1A10044154 to J.K).
Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted ...
supported by the Key R&D Program of the Science and Technology Ministry of China(No.2021YFC2701100);the National Natural Science Foundation of China(No.82150008,81930036)。
Alzheimer’s disease(AD)remains clinically incurable,raising a significant public health issue,particularly with its continuously increased incidence.1 Inflammatory bowel disease,including ulcerative colitis and Crohn...
This editorial comments on the article by Wu et al in the World Journal of Gastroenterology.The article explored the relationship between mesenteric adipose tissue,creeping fat,inflammation,and gut microbiota in Crohn...
Supported by the National Natural Science Foundation of China,No.81873297;the Fundamental Research Funds for the Central Public Welfare Research Institutes,No.ZZ13-YQ-006;China Academy of Chinese Medical Sciences Innovation Fund,No.CI2021A01003;the Hospital Capability Enhancement Project of Xiyuan Hospital,China Academy of Chinese Medical Sciences,No.XYZX0303-07.
Eukaryotic cells contain the endoplasmic reticulum(ER),a prevalent and intricate membranous structural system.During the development of inflammatory bowel disease(IBD),the stress on the ER and the start of the unfolde...
Supported by General Hospital Integrated Guidance Project of Shanghai Municipal Health Commission and Municipal Administration of Traditional Chinese Medicine(Phase I),No.ZXXT-202210;"Science and Technology Innovation Action Plan"Medical Innovation Research Project of Shanghai Municipal Science and Technology Commission,No.22Y11907900.
BACKGROUND Epstein-Barr virus(EBV)infection of the intestinal mucosa is associated with surgical risk in ulcerative colitis(UC);however,the exact effect remains unclear.AIM To determine whether EBV infection can predi...
supported by the National Key Research and Development Program of China(2023YFF1103802)。
The anti-inflammatory properties of silkworm pupa peptide(SPP)have been recognized for their potential benefits in colitis treatment.However,the underlying mechanism of SPP in colitis animal models remains unclear.The...
BACKGROUND Intestinal ultrasound(IUS)is a safe and effective way for the diagnosis and surveillance of patients with inflammatory bowel disease(IBD).It allows a noninvasive and reproducible follow-up for patients with...
National Natural Science Foundation of China(82274641,81873372,and 82105012).
Objective To investigate the mechanism of in alleviating colonic mucosal inflammation in ten-eleven translocation(TET)protein 2 gene knockout(TET2^(-/-))mice with ulcerative colitis(UC)by regulating DNA methyltransfer...
Supported by China Academy of Chinese Medical Sciences Outstanding Young Talents(Innovative)Cultivation Project,No.ZZ17-YQ-007;Special Project of the National Natural Science Foundation of China,No.82341233.
BACKGROUND The interleukin-17(IL-17)mediated aberrant immune-inflammatory response plays a paramount role in ulcerative colitis(UC).γδT17 cells are one of the critical sources of IL-17,but the role they play in UC r...