BACKGROUND Hepatocellular carcinoma(HCC)is a prevalent malignancy in China,primarily diagnosed at advanced stages,which limits treatment options and increases mortality rates.Conversion therapy,which includes systemic...
supported by the National Natural Science Foundation of China(82203447);the Natural Science Foundation of Sichuan,China(2022NSFSC1424);the Postdoctoral Research Project,West China Hospital,Sichuan University(18HXBH068)。
In cancer,the proto-oncogene RAS frequently mutates at codons 12,13,and 61,with these mutations propelling tumor progression by locking RAS proteins in their active,GTP-bound state(Pylayeva-Gupta et al.,2011;Yang et a...
Supported by the Shanghai Science and Technology Commission Project,No.21010504300;Shanghai Jiading District Traditional Chinese Medicine Key Specialty Construction Project,No.2020-JDZYYZDZK-01.
BACKGROUND In recent years,numerous reports have been published regarding the relationship between the gut microbiota and the tumor immune microenvironment(TIME).However,to date,no systematic study has been conducted ...
It’s that time of the year again when we find ourselves reflecting on the year that was and the year ahead.On the African continent,many countries are still recovering from the aftershocks of the COVID-19 pandemic an...
supported by the National Natural Science Foundation of China(81930078 and 82330083 to Q.Y.and 81902838 to L.L.);the National Key Research and Development Program of China(2022YFA1104003 to Q.Y.);Natural Science Foundation of Beijing(7204284 to L.L.);Basic and Clinical Collaborative Research Enhanced Program of Anhui Medical University(2021xkjT025 to B.Y.);the Doctoral Start-up Foundation of Anhui Medical University(0110050201 to B.Y.).
Aerobic glycolysis is a hallmark of cancer and is regulated by growth factors,protein kinases and transcription factors.However,it remains poorly understood how these components interact to regulate aerobic glycolysis...