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Trivalent SARS-CoV-2 virus-like particle vaccines exhibit broad-spectrum neutralization and protection against XBB.1 and BA.2.86 variants
《Virologica Sinica》2024年第5期836-839,共4页Lu Zhang Siyu Tian Jun Dai Yuanyuan Li Yu Zhou Yan Li Jiao Xu Shuyun Liu Zhiwei Lin Zhaoyong Zhang Jiantao Chen Peilan Wei Jingxian Zhao Jing Jin Yanqun Wang Jincun Zhao 
supported by a grant from the National Key R&D Program of China(2023YFC3041600 YW,the National Natural Science Foundation of China(82025001 JZ,92369113 YW,82172240 YW);Guangdong Basic and Applied Research Projects(2023B1515020040 YW,2021B1515130005 JZ,2021B1212030016 JD,2021A1111100009 JD);Science and Technology Planning Project of Guangzhou City(2023A04J1279 LZ);ZhongNanShan Medical Foundation of Guangdong Province(ZNSA-2020013 JZ);the Science and Technology Project of General Administration of Customs,P.R.China(2023HK065 LZ);State Key Laboratory of Respiratory Disease(SKLRD-Z-202214,SKLRD-OP-202309 YW,SKLRD-Z-202411 LZ);the Self-supporting Program of Guangzhou Laboratory(GZNL2023A01006,SRPG22-001);Guangzhou Medical University(YP2022005 YW);Korea Institute of Planning and Evaluation for Technology in Food,Agriculture and Forestry(IPET)through Animal Disease Management Technology Advancement Support Program,funded by the Ministry of Agriculture,Food and Rural Affairs(MAFRA)(122012-2,122060-2 JZ);the National Clinical Research Center for Respiratory Disease(BRD-NCRCRD,Guangzhou,Southern China).Patronus Biotech is a company researching virus-like particle display technology and vaccines.Yu Zhou and Jing Jin are named inventors on a patent invention relating to the described novel SARS-CoV-2 virus-like particle vaccine.All BALB/c mouse experiments complied with relevant ethical regulations for animal research and were approved by the LUYE PHARMA Animal Experimentation Ethics Committee.The K18-hACE2 mouse experiment was reviewed and approved by the Institutional Animal Care and Use Committees of Guangzhou Medical University(2023-0451).All authors declare that they have no conflict of interests.
Dear Editor,The newly emerged severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron subvariants(XBB.1,EG.5 and JN.1)and sublineages have been circulating globally with superior growth advantages over othe...
关键词：VACCINE vaccines acute 
RNA barcode segments for SARS-CoV-2 identification from HCoVs and SARSr-CoV-2 lineages
《Virologica Sinica》2024年第1期156-168,共13页Changqiao You Shuai Jiang Yunyun Ding Shunxing Ye Xiaoxiao Zou Hongming Zhang Zeqi Li Fenglin Chen Yongliang Li Xingyi Ge Xinhong Guo 
supported by grants from Key Research&Development Project of Nanhua Biomedical Co.,Ltd.(No.H202191490139);National Natural Science Foundation of China(No.31872866);China Postdoctoral Science Foundation(Nos.2021M701160 and 2022M721101);Funds of Hunan university(521119400156).
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the pathogen responsible for coronavirus disease 2019(COVID-19),continues to evolve,giving rise to more variants and global reinfections.Previous research ha...
关键词：RNA barcode segments SARS-CoV-2 variants and related lineages HCoVs Genetic tests Complete genome sequences 
Delta(B.1.617.2)inactivated vaccine candidate elicited neutralizing antibodies to SARS-CoV-2 and circulating variants in rhesus macaques
《Virologica Sinica》2023年第4期627-630,共4页Yanjun Zhang Haiyan Mao Ju Li Jianhua Li Chen Huang Jiaxuan Li Minglei Chu Fengbo Xue Linhui Wang Zhongbiao Fang Zhen Wang Jinan Wu Keda Chen 
supported by the Science and Technology Program of Zhejiang Province (#2022C03017);Key Research and Development Program of Zhejiang Province (#2021C03044);Major Health Science and Technology Projects of Zhejiang Province (#WKJ-ZJ-2105);National Key R&D Program of China (#2021YFC2301200).
Dear Editor,The coronavirus disease 2019(COVID-19)pandemic has resulted in 763 million cases and over 6 million deaths as of April 2023.Given the high prevalence and widespread distribution of coronaviruses,the geneti...
关键词：ANTIBODIES VACCINE 
Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees被引量：1
《Virologica Sinica》2023年第2期233-243,共11页Pei Yu Zijian Liu Zhuoqi Zhu Jiaqing Yang Min Deng Mingxiao Chen Changchun Lai Weiya Kong Shilong Xiong Li Wan Weikang Mai Lu Chen Yu Lei Shahzad Akbar Khan Jianfeng Ruan An Kang Xuguang Guo Qiang Zhou Wenrui Li Zheng Chen Yuemei Liang Pingchao Li Lei Zhang Tianxing Ji 
Guangzhou Health Science and Technology Project(20201A011078);Guangzhou Science and Technology Project(202102010094);Guangdong Basic and Applied Basic Research Foundation(2021A1515012550);Clinical research project of Guangzhou Medical University Second Affiliated Hospital(2021-LCYJ-05);Guangdong Medical Research Fund(A2022255);Key Clinical Specialty of Guangzhou Medical University(0F03031);Guangzhou Laboratory(EKPG21-30-3);Guangzhou key discipline of urology.The funding sources had no role in the study design,data collection,analysis,interpretation,or writing of the report.
Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron variants.Questions concerning about memory B cells(MBCs)and T cells immunity a...
关键词：Inactivated vaccine booster Ad5-nCoV booster Omicron variants breakthrough infection Memory immunity Binding antibody 
Hybridoma-derived neutralizing monoclonal antibodies against Beta and Delta variants of SARS-CoV-2 in vivo
《Virologica Sinica》2023年第2期257-267,共11页Qianran Wang Lu Peng Yanqiu Nie Yanni Shu Huajun Zhang Zidan Song Yufeng Li Hengrui Hu Liushuai Li Xi Wang Jia Liu Jiang Li Zhengli Shi Fei Deng Yu Guo Yiwu Zhou Bing Yan Zhihong Hu Manli Wang 
supported by grants from the National Key R&D Program of China(2021YFC2301700);National Natural Science Foundation of China(82061138021);the Key Biosafety Science and Technology Program of Hubei Jiangxia Laboratory(JXBS001);Hubei Natural Science Foundation for Distinguished Young Scholars(2021CFA050).
Neutralizing monoclonal antibodies(mAb)are a major therapeutic strategy for the treatment of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection.The continuous emergence of new SARS-CoV-2 variants wor...
关键词：COVID-19 SARS-CoV-2 B.1.351 B.1.617.2 Monoclonal antibody 
Structures of SARS-CoV-2 spike protein alert noteworthy sites for the potential approaching variants
《Virologica Sinica》2022年第6期938-941,共4页Xiaorui Xing Lei Wang Zhen Cui Wangjun Fu Tao Zheng Lili Qin Pingju Ge Aidong Qian Nan Wang Shuai Yuan 
supported by funding from Beijing Natural Science Foundation-Haidian Primitive Innovation Joint fund(L192008);the National Key R&D Program(2020YFA0707500,2018YFA0900801,2021YFA1301400);the National Natural Science Foundation of China(31872730 and 32070947)
Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane sur...
关键词：ACE2 al. ACUTE 
Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum
《Virologica Sinica》2022年第6期831-841,共11页Yuqi Zhu Xinyi Yang Jingna Xun Jun Liu Qing Wen Yixiao Lin Xiaoting Shen Jun Chen Songhua Yuan Xiaying Zhao Jing Wang Hanyu Pan Jinlong Yang Zhiming Liang Yue Liang Qinru Lin Huitong Liang Min Li Jianping Liu Yinzhong Shen Xiaoyan Zhang Pengfei Wang Daru Lu Chunhua Yin Jianqing Xu Shibo Jiang Hongzhou Lu Huanzhang Zhu 
supported by the National Natural Science Foundation of China (82041001, 81761128020)
The prevalence of SARS-CoV-2 variants of concern(VOCs) is still escalating throughout the world. However, the level of neutralization of the inactivated viral vaccine recipients’ sera and convalescent sera against al...
关键词：SARS-CoV-2 Variants of concern(VOCs) Convalescent BBIBP-CorV vaccine NEUTRALIZATION 
Nasal delivery of broadly neutralizing antibodies protects mice from lethal challenge with SARS-CoV-2 delta and omicron variants被引量：6
《Virologica Sinica》2022年第2期238-247,共10页Jia Lu Qiangling Yin Rongjuan Pei Qiu Zhang Yuanyuan Qu Yongbing Pan Lina Sun Ding Gao Cuiqin Liang Jingwen Yang Wei Wu Jiandong Li Zongqiang Cui Zejun Wang Xinguo Li Dexin Li Shiwen Wang Kai Duan Wuxiang Guan Mifang Liang Xiaoming Yang 
supported by National Key Research and Development Program of China(2021YFC2600200,2017YFA0205100)。
Multiple new variants of severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)have constantly emerged,as the delta and omicron variants,which have developed resistance to currently gained neutralizing antibodie...
关键词：Coronavirus disease 2019(COVID-2019) Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Prophylactic protection Omicron variant K18-h ACE2 
Antibody Cocktail Exhibits Broad Neutralization Activity Against SARS-CoV-2 and SARS-CoV-2 Variants被引量：6
《Virologica Sinica》2021年第5期934-947,共14页Yuanyuan Qu Xueyan Zhang Meiyu Wang Lina Sun Yongzhong Jiang Cheng Li Wei Wu Zhen Chen Qiangling Yin Xiaolin Jiang Yang Liu Chuan Li Jiandong Li Tianlei Ying Dexin Li Faxian Zhan Youchun Wang Wuxiang Guan Shiwen Wang Mifang Liang 
supported by the National Science and Technology Major Project(2018ZX10711-001)(2017YFA0205100)。
Severe acute respiratory syndrome coronavirus 2(SARS-Co V-2)has precipitated multiple variants resistant to therapeutic antibodies.In this study,12 high-affinity antibodies were generated from convalescent donors in e...
关键词：Antibody cocktail Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) Broad neutralization SARS-CoV-2 variants Angiotensin-converting enzyme 2(ACE2) 
Effect of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1 Alpha Variants on Spontaneous Clearance and Fibrosis Progression during Hepatitis C Virus Infection in Moroccan Patients
《Virologica Sinica》2020年第5期566-574,共9页Raouia ElFihry Mohcine Elmessaoudi-Idrissi Fatima-Zahra Jadid Imane Zaidane Hajar Chihab Mohamed Tahiri Mostafa Kabine Wafaa Badre Isabelle Chemin Agnes Marchio Pascal Pineau Sayeh Ezzikouri Soumaya Benjelloun 
Hepatitis C virus(HCV)is still one of the main causes of liver disease worldwide.Metabolic disorders,including nonalcoholic fatty liver disease(NAFLD),induced by HCV have been shown to accelerate the progression of fi...
关键词：Chronic hepatitis C Peroxisome proliferator-activated receptor gamma coactivator 1-alpha(PPARGC1A) POLYMORPHISMS Disease progression 
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