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COVID-19 vaccine updates for people under different conditions
《Science China(Life Sciences)》2024年第11期2323-2343,共21页Yijiao Huang Weiyang Wang Yan Liu Zai Wang Bin Cao 
supported by the National Natural Science Foundation of China(82241056,82170015,82100009,82030002);Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2021-I2M-1-048);New Cornerstone Science Foundation,National Key R&D Program of China(2023YFC2306300);National Key R&D Program of China(2023YFC2306300).
SARS-CoV-2 has caused global waves of infection since December 2019 and continues to persist today.The emergence of SARS-CoV-2 variants with strong immune evasion capabilities has compromised the effectiveness of exis...
关键词：SARS-CoV-2 VACCINE variants of concern ELDERLY IMMUNOCOMPROMISED 
Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern
《Journal of Molecular Cell Biology》2024年第3期9-23,共15页Ilaria Frasson Linda Diamante Manuela Zangrossi Elena Carbognin Anna Dalla Pietà Alessandro Penna Antonio Rosato Ranieri Verin Filippo Torrigiani Cristiano Salata Marìa Paula Dizanzo Lorenzo Vaccaro Davide Cacchiarelli Sara N.Richter Marco Montagner Graziano Martello 
supported by the CaRiPaRo Foundation(NewTarCoV2);the Ministry of Education,University and Research(PRIN-2020KSY3KL);supported by the Telethon Foundation Core Grant,European Research Council(ERC)(CellKarma);Regione Campania(PO-FESR 2014-2020,PO-FESR 2014-2020);Italian Ministry of Health(Piano Operativo Salute Traiettoria 3,‘Genomed’).supported by the Giovanni Armenise-Harvard Foundation,the Telethon Foundation(TCP13013);ERC(ERC Starting Grant,‘MetEpiStem’);supported by ERC(ERC Consolidator 615879);the Bill and Melinda Gates Foundation(OPP1035881 and OPP1097238);the Italian Foundation for Cancer Research(AIRC 21850);the Collaborative Center for XDP at Massachusetts General Hospital(239295);supported by the Italian Foundation for Cancer Research(AIRC-MFAG 25745);University of Padua(STARS Consolidator Grant,‘EMERALD’);supported by the Italian Foundation for Cancer Research(AIRC 2135);Italian Ministry of Health(RCR-201923669115,NET-201602361632);supported by the EVA-GLOBAL project that has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement number 871029;EVA-GLOBAL provided access to SARS-CoV-2 Alpha and Delta isolates(human nCoV19 isolate/England/MIG457/2020 and hCoV-19/Netherlands/NH-RIVM-27142/2021_P2).
The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants,some of which are resistant to vaccines and drugs targeting viral elements.Targeting host dependency factors,e.g.cellular proteins requi...
关键词：SARS-CoV-2 variants of concern host dependency factors antivirals N-acetyl cysteine 
Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected Rhesus Macaques
《Genomics, Proteomics & Bioinformatics》2023年第5期1014-1029,共16页Tingfu Du Chunchun Gao Shuaiyao Lu Qianlan Liu Yun Yang Wenhai Yu Wenjie Li Yong Qiao Sun Cong Tang Junbin Wang Jiahong Gao Yong Zhang Fangyu Luo Ying Yang Yun-Gui Yang Xiaozhong Peng 
supported by the National Key R&D Program of China(Grant No.2021YFC0863300);the Strategic Priority Research Program of Chinese Academy of Sciences(Grant No.XDB0490000);the CAMS Innovation Fund for Medical Sciences(Grant No.2021-I2M-1-024);the STI2030-Major Projects(Grant No.2021ZD0200900);the Foundation for Innovative Research Groups of the National Natural Science Foundation of China(Grant No.82221004);the National Natural Science Foundation of China(Grant Nos.32121001,32200460,and 32200460);the K.C.Wong Education Foundation(Grant No.GJTD-2019-08);the Shanghai Municipal Science and Technology Major Project,China(Grant No.2017SHZDZX01);the China National Postdoctoral Program for Innovative Talents(Grant No.BX2021291).
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the persistent coronavirus disease 2019(COVID-19)pandemic,which has resulted in millions of deaths worldwide and brought an enormous public health and ...
关键词：SARS-CoV-2 Variant of concern Subgenomic RNA Rhesus macaque TRANSCRIPTOME 
Quantification and Differentiation of SARS-CoV‑2 Variants in Wastewater for Surveillance
《Environment & Health》2023年第3期203-213,共11页Teresa Kumblathan Yanming Liu Xiaoli Pang Steve E.Hrudey XChris Le Xing-Fang Li 
Wastewater surveillance plays an important role in the monitoring of infections of SARS-CoV-2 at the community level.We report here the determination of SARS-CoV-2 and differentiation of its variants of concern in 294...
关键词：COVID-19 SARS-CoV-2 variants of concern Omicron subvariants multiplex RT-qPCR wastewater surveillance 
Antibody fragment V_(H)ab6:universal neutralizer for SARS-CoV-2 variants
《Journal of Bio-X Research》2023年第2期73-77,共5页Mujahed I.Mustafa Abdelrafie M.Makhawi 
The recent coronavirus disease 2019(COVID-19)outbreak has highlighted the inadequacy of our ability to respond to newly emerging viruses.Antiviral medications are the most effective means of combating the pandemic,yet...
关键词：COVID-19 omicron variants SARS-CoV-2 variants of concern V_(H)ab6 
Mutated trimeric RBD vaccines:a platform against variants of concern
《Signal Transduction and Targeted Therapy》2023年第5期2038-2040,共3页Belén Aparicio Juan J.Lasarte Pablo Sarobe 
supported by Instituto de Salud Carlos III,Fondo Europeo de Desarrollo Regional"Una manera de hacer Europa"under grant PI20/00260,Gobierno de Navarra under grant 0011-3597-2020-000024 to PS and by Paula&Rodger Riney Foundation to JJL.
He et al.recently reported in Nature Communications1 the development of a protein vaccine against SASR-CoV-2 Omicron variant consisting of a trimer of the spike protein receptor-binding domain(RBD)of the Delta variant...
关键词：VACCINE vaccines 
Simulating potential outbreaks of Delta and Omicron variants based on contact-tracing data:A modelling study in Fujian Province,China被引量：2
《Infectious Disease Modelling》2023年第1期270-281,共12页Yichao Guo Wenjing Ye Zeyu Zhao Xiaohao Guo Wentao Song Yanhua Su Benhua Zhao Jianming Ou Yanqin Deng Tianmu Chen 
supported by the Bill&Melinda Gates Foundation(INV-005834),Natural Science Foundation of Fujian Province(NO.2021J01353,NO.2020J01094);National Science and Technology Major Project of the Ministry of Science and Technology of China(NO.2018ZX10734402-007);Research on accurate prediction and timely response system for out-breaks of new infectious diseases(SRPG2200702);Fundamental Research Funds for the Central Universities(No.20720230001).
Although studies have compared the relative severity of Omicron and Delta variants by assessing the relative risks,there are still gaps in the knowledge of the potential COVID-19 burden these variations may cause.And ...
关键词：Contact tracing Vaccine effectiveness Variant of concern Mathematical model COVID-19 
Mathematical modeling of the dynamics of COVID-19 variants of concern:Asymptotic and finite-time perspectives
《Infectious Disease Modelling》2022年第4期581-596,共16页Adriana-Stefania Ciupeanu Marie Varughese Weston C.Roda Donglin Han Qun Cheng Michael Y.Li 
funded in part by NSERC Alliance COVID-19 grant(ALLRP 555037-20);NSERC Discovery grant(RGPIN-2020-04134 Li);the CIHR funded Mathematical Modelling of COVID-19 Task Force,and the NSERC-PHAC EIDM Network“Mathematics for Public Health(MfPH)”.
The COVID-19 pandemic has seen multiple waves,in part due to the implementation and relaxation of social distancing measures by the public health authorities around the world,and also caused by the emergence of new va...
关键词：COVID-19 pandemic Variants of concern Mathematical modeling Coexistence and replacement of variants Public health measures 
Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum
《Virologica Sinica》2022年第6期831-841,共11页Yuqi Zhu Xinyi Yang Jingna Xun Jun Liu Qing Wen Yixiao Lin Xiaoting Shen Jun Chen Songhua Yuan Xiaying Zhao Jing Wang Hanyu Pan Jinlong Yang Zhiming Liang Yue Liang Qinru Lin Huitong Liang Min Li Jianping Liu Yinzhong Shen Xiaoyan Zhang Pengfei Wang Daru Lu Chunhua Yin Jianqing Xu Shibo Jiang Hongzhou Lu Huanzhang Zhu 
supported by the National Natural Science Foundation of China (82041001, 81761128020)
The prevalence of SARS-CoV-2 variants of concern(VOCs) is still escalating throughout the world. However, the level of neutralization of the inactivated viral vaccine recipients’ sera and convalescent sera against al...
关键词：SARS-CoV-2 Variants of concern(VOCs) Convalescent BBIBP-CorV vaccine NEUTRALIZATION 
Naturally occurring spike mutations influence the infectivity and immunogenicity of SARS-CoV-2被引量：1
《Cellular & Molecular Immunology》2022年第11期1302-1310,共9页Qiaoli Peng Runhong Zhou Na Liu Hui Wang Haoran Xu Meiqing Zhao Dawei Yang Ka-Kit Au Haode Huang Li Liu Zhiwei Chen 
This study was supported by the Hong Kong Research Grants Council Collaborative Research Fund(C7156-20GF to ZC and C1134-20GF);the Research Grants Council General Research Fund(GRF17117422);the Hong Kong Health and Medical Research Fund(COVID1903010-Project 4,COVID190123 and 19181012);the Shenzhen Science and Technology Program(JSGG20200225151410198 and JCYJ20210324131610027);HKU Development Fund and LKS Faculty of Medicine Matching Fund to AIDS Institute;the Hong Kong Innovation and Technology Fund;the Hong Kong Health@InnoHK,Innovation and Technology Commission;a generous donation from the Friends of Hope Education Fund.ZC’s team was also partly supported by the Theme-Based Research Scheme(T11-706/18-N and T11-709/21-N).
Mutations in SARS-CoV-2 variants of concern(VOCs)have enhanced transmissibility and immune evasion with respect to current vaccines and neutralizing antibodies(NAbs).How naturally occurring spike mutations affect the ...
关键词：SARS-CoV-2 Variants of Concern Single mutation neutralizing antibody T cell responses vaccine immunogenicity 
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