VARIANTS

作品数：613被引量：1047H指数：14
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Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants
《Acta Pharmaceutica Sinica B》2025年第2期947-962,共16页Yi Wu Xiaoying Jia Namei Wu Xinghai Zhang Yan Wu Yang Liu Minmin Zhou Yanqiong Shen Entao Li Wei Wang Jiaming Lan Yucai Wang Sandra Chiu 
the National Virus Resource Center for kindly providing SARS-CoV-2 Omicron BA.1(CCPM-B-V-049-2112-18)and BA.5(NPRC2.062200006);supported by the National Key R&D Program of China(2020YFA0710700);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0490000,China);the National Natural Science Foundation of China(52025036,51961145109);the Shanghai“Belt and Road”Joint Laboratory Project(22490750200,China);This work was partially carried out at the USTC Center for Micro and Nanoscale Research and Fabrication.
Booster vaccinations are highly recommended in combating the SARS-CoV-2 Omicron variant and its subvariants.However,the optimal booster vaccination strategies and related immune mechanisms with different prior vaccina...
关键词：SARS-CoV-2 Omicron Subvariants Omicron-specific mRNA vaccine Commercial vaccines Booster vaccination Immune response 
Advancements in oral therapeutic drugs for treating SARS-CoV-2 infections:A comprehensive review
《Journal of Chinese Pharmaceutical Sciences》2024年第11期1082-1089,共8页Li Wang Meng Rui Jun Peng Yun Ling 
SARS-CoV-2 has undergone five major transformations from its original strain,evolving through Alpha,Beta,Gamma,Delta,and now Omicron.The Omicron variant stands out for its high transmissibility,reduced severity,mild s...
关键词：SARS-CoV-2 infections Omicron variants Oral therapeutic drugs Research progress 
Detection of SARS-CoV-2 and Its Mutated Variants Using RT-LAMP-CRISPR-Cas12a Platform
《Wuhan University Journal of Natural Sciences》2024年第5期453-460,共8页WANG Shanshan YAN Jun DU Tongtong LIU Luo CHEN Xiong HAN Song YIN Jun PENG Biwen HE Xiaohua LU Xuan LIU Wanhong 
Supported by the National Natural Sciences Foundation of China(52073022);the Fundamental Research Funds for the Central Universities of China and the Translational Medical Research Fund of Wuhan University Taikang Medical School(School of Basic Medical Sciences);the Key Laboratory of Environmental Pollution Monitoring and Disease Control(Guizhou Medical University)Ministry of Education(GMU-2022-HJZ)。
The global outbreak of coronavirus disease 19(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2),has raised significant global apprehension.Developing a rapid,efficient,sensitive,and accu...
关键词：SARS-CoV-2 mutation CRISPR RT-LAMP point-of-care diagnosis 
Assessing the inhibition efficacy of clinical drugs against the main proteases of SARS-CoV-2 variants and other coronaviruses
《Quantitative Biology》2024年第3期324-328,共5页Wenlong Zhao Cecylia SLupala Shifeng Hou Shuxin Yang Ziqi Yan Shujie Liao Xuefei Li Nan Li 
National Key Research and Development Program of China,Grant/Award Number:2023YFA0913900;National Natural Science Foundation of China,Grant/Award Numbers:31971354,32100146,32170672,32271501。
The rapid evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)mainly due to its high mutation rate and rapid viral replication,has led to new variants resistant to the available vaccines and monocl...
关键词：drug resistance enzymatic activity main protease SARS-CoV-2 
Impact of a Mass Campaign on the Evolution of the Fourth Wave of the Covid-19 Pandemic in the Central African Republic
《Journal of Tuberculosis Research》2024年第3期142-150,共9页Clotaire Donatien Rafaï Pierre Somse Wilfrid Sylvain Nambei Ernest Lango-Yaya Marie-Roseline Darnycka Belizaire Ulrich Vickos Narcisse Patrice Komas Oscar Senzongo Luc Salva Heredeibona Ulrich Jeffrey Kotemossoua Rabbi Mermoz Senekian Simon Pounguinza Jephté Estimé Kaleb Christian-Diamant Mossoro-Kpinde Alain Le Faou Jean De Dieu Longo Norbert Richard Ngbale Abdoulaye Sepou François-Xavier Mbopi-Keou Gérard Grésenguet Boniface Koffi 
Objective: In the context of increasing cases despite vaccination campaigns, a survey was conducted in the Bangui population from January 17 to 26, 2022, to evaluate the strains of Severe Acute Respiratory Infection C...
关键词：COVID-19 SARS-CoV-2 Variants 
Contribution of Genomic Surveillance in the Detection and Monitoring of SARS-CoV-2 Variants during the 6 Pandemic Waves in the Central African Republic from 2020 to 2023
《Journal of Tuberculosis Research》2024年第3期151-164,共14页Clotaire Donatien Rafaï Ernest Lango-Yaya Marie Roseline Darnicka Belizaire Ouoko Fa-Ti-Gbia Maurel Annicet Adonis Marcel Mbeko Simaleko Jean-Baptiste Roungou Oscar Senzongo Karl G. Njuwa Fai Boniface Koffi 
Objective: The COVID-19 pandemic has highlighted the need to strengthen diagnosis and genomic surveillance capacities. In 2021, Central African managed five waves of COVID-19 by integrating genomic surveillance into t...
关键词：SARS-CoV-2 VARIANTS Central African Republic RT-PCR 
Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies被引量：2
《Signal Transduction and Targeted Therapy》2024年第6期2359-2361,共3页Xun Wang Shujun Jiang Wentai Ma Yanliang Zhang Pengfei Wang 
supported by funding from the National Natural Science Foundation of China(32270142 to P.W.);the Shanghai Rising-Star Program(22QA1408800 to P.W.);the Program of Science and Technology Cooperation with Hong Kong region,Macao region,and Taiwan region(23410760500 to P.W.);Nanjing Research Center for Infectious Diseases of Integrated Traditional Chinese and Western Medicine(YBZX2022 to Y.Z.);NATCM’s Project of High-level Construction of Key TCM Disciplines;support from AI for Science project of Fudan University(XM06231724);Open Research Fund of State Key Laboratory of Genetic Engineering,Fudan University(No.SKLGE-2304);Xiaomi Young Talents Program.
Dear Editor,The rapid and widespread transmission of SARS-CoV-2 has led to the emergence of multiple variants of concern(VOCs),most notably the Omicron variant,which continues to evolve and diversify into a range of s...
关键词：evolve NEUTRALIZATION VARIANTS 
A human monoclonal antibody neutralizes SARS-CoV-2 Omicron variants bytargeting the upstream region of spike protein HR2 motif
《hLife》2024年第3期126-140,共15页Hang Su Jun Zhang Zhenfei Yi Sajid Khan Mian Peng Liang Ye Alan Bao Han Zhang Guangli Suo Qian Li Housheng Zheng Dandan Wu Thomas J.Kipps Lanfeng Wang Zhenghong Lin Suping Zhang 
funded bythe National Natural Science Foundation of China(81972753,32170712,and 32170937);R&D Program of Guangzhou National Laboratory(SRPG22-003);the China Postdoctoral Science Foundation(2019M663093);Prevention and Control ofCOVID-2019 Research Program in University of GuangdongProvince(2020KZDZX1176);the Science and TechnologyProgram of Guangdong Province,China(2020A1515110410and 2021A1515010917);the Guangdong Medical Scienceand Technology Research Foundation(A2021336);ShenzhenKey Laboratory Foundation(ZDSYS20200811143757022);theShenzhen Science and Technology Basic Research Program(JCYJ20180507182203049 and JCYJ20230807142815034);and the Shenzhen University(SZU)Top Ranking Project(86000000210).
The continuous emergence of new severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants meansthere is a need to explore additional strategies to develop broad-spectrum vaccines or therapeutics for individu...
关键词：coronavirus disease 2019(COVID-19) severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variants monoclonal antibody upstream region of heptad repeat 2(HR2) immunoglobulin repertoiresequencing 
Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern
《Journal of Molecular Cell Biology》2024年第3期9-23,共15页Ilaria Frasson Linda Diamante Manuela Zangrossi Elena Carbognin Anna Dalla Pietà Alessandro Penna Antonio Rosato Ranieri Verin Filippo Torrigiani Cristiano Salata Marìa Paula Dizanzo Lorenzo Vaccaro Davide Cacchiarelli Sara N.Richter Marco Montagner Graziano Martello 
supported by the CaRiPaRo Foundation(NewTarCoV2);the Ministry of Education,University and Research(PRIN-2020KSY3KL);supported by the Telethon Foundation Core Grant,European Research Council(ERC)(CellKarma);Regione Campania(PO-FESR 2014-2020,PO-FESR 2014-2020);Italian Ministry of Health(Piano Operativo Salute Traiettoria 3,‘Genomed’).supported by the Giovanni Armenise-Harvard Foundation,the Telethon Foundation(TCP13013);ERC(ERC Starting Grant,‘MetEpiStem’);supported by ERC(ERC Consolidator 615879);the Bill and Melinda Gates Foundation(OPP1035881 and OPP1097238);the Italian Foundation for Cancer Research(AIRC 21850);the Collaborative Center for XDP at Massachusetts General Hospital(239295);supported by the Italian Foundation for Cancer Research(AIRC-MFAG 25745);University of Padua(STARS Consolidator Grant,‘EMERALD’);supported by the Italian Foundation for Cancer Research(AIRC 2135);Italian Ministry of Health(RCR-201923669115,NET-201602361632);supported by the EVA-GLOBAL project that has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement number 871029;EVA-GLOBAL provided access to SARS-CoV-2 Alpha and Delta isolates(human nCoV19 isolate/England/MIG457/2020 and hCoV-19/Netherlands/NH-RIVM-27142/2021_P2).
The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants,some of which are resistant to vaccines and drugs targeting viral elements.Targeting host dependency factors,e.g.cellular proteins requi...
关键词：SARS-CoV-2 variants of concern host dependency factors antivirals N-acetyl cysteine 
SARS-CoV-2 variants are associated with different clinical courses in children with MIS-C
《World Journal of Pediatrics》2024年第2期143-152,共10页Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane C.Burns Kirsten B.Dummer 
Background Recent infection with SARS‑CoV-2 in children has been associated with multisystem inflammatory syndrome in children(MIS-C).SARS‑CoV-2 has undergone different mutations.Few publications exist about specific ...
关键词：COMPLICATIONS COVID-19 MIS-C SARS-CoV-2 variants 
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