VCP

作品数：113被引量：94H指数：4
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Derlin-1 and TER94/VCP/p97 are required for intestinal homeostasis
《Journal of Genetics and Genomics》2022年第3期195-207,共13页Fuli Liu Hang Zhao Ruiyan Kong Lin Shi Zhengran Li Rui Ma Huiqing Zhao Zhouhua Li 
supported by grants from the National Natural Science Foundation of China (31972893, 92054109 and 31471384);Beijing Municipal Commission of Education (No KZ201910028040);Beijing Natural Science Fundation (No 5162004)。
Adult stem cells are critical for the maintenance of residential tissue homeostasis and functions. However,the roles of cellular protein homeostasis maintenance in stem cell proliferation and tissue homeostasis are no...
关键词：Derlin-1 TER94/VCP/p97 ERAD Intestinal homeostasis DROSOPHILA 
Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster
《Journal of Genetics and Genomics》2017年第10期493-501,共9页Dwayne J.Byrne Mark J.Harmon Jeremy C.Simpson Craig Blackstone Niamh C. O'Sullivan 
supported by a Wellcome Trust-NIH PhD studentship(200927/Z/16/Z);a Wellcome Trust Vacation Studentship (WT200927)
The VCP-Ufd1-Npl4 complex regulates proteasomal processing within cells by delivering ubiquitinated proteins to the proteasome for degradation.Mutations in VCP are associated with two neurodegenerative diseases,amyotr...
关键词：PROTEASOME TDP-43 accumulation NEURODEGENERATION DROSOPHILA 
Characterization of the Drosophila Atlastin Interactome Reveals VCP as a Functionally Related Interactor被引量：1
《Journal of Genetics and Genomics》2013年第6期297-306,共10页Niamh C.O'Sullivan Nina Dräger Cahir J.O'Kane 
supported by Marie Curie Individual Fellowship 236777
At least 25 genes,many involved in trafficking,localisation or shaping of membrane organelles,have been identified as causative genes for the neurodegenerative disorder hereditary spastic paraplegia（HSP）.One of the ...
关键词：Endoplasmic reticulum Hereditary spastic paraplegias Atlastin Valosin-containing protein 
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