YIGSR

作品数:22被引量:37H指数:4
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相关领域:医药卫生更多>>
相关作者:赵铁华彭师奇赵明杨鹤松高巍更多>>
相关机构:首都医科大学承德医学院华中科技大学中国医学科学院北京协和医学院更多>>
相关期刊:《离子交换与吸附》《Chinese Medical Journal》《华中科技大学学报(医学版)》《肿瘤》更多>>
相关基金:国家自然科学基金河北省自然科学基金广东省自然科学基金天津市自然科学基金更多>>
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Coaxial-printed small-diameter polyelectrolyte-based tubes with an electrostatic self-assembly of heparin and YIGSR peptide for antithrombogenicity and endothelialization被引量:7
《Bioactive Materials》2021年第6期1628-1638,共11页Zhiwen Zeng Chengshen Hu Qingfei Liang Lan Tang Delin Cheng Changshun Ruan 
The authors gratefully acknowledge the support for this work from the National Key research and Development Program(Grant No.2018YFA0703100);the National Natural Science Foundation of China(Grant Nos.82072082,31900959);the Youth Innovation Promotion Association of CAS(Grant No.2019350);the Guangdong Natural Science Foundation(Grant No.2019A1515011277);the Shenzhen Fundamental Research Foundation(Grant No.JCYJ20180507182237428).
Low patency ratio of small-diameter vascular grafts remains a major challenge due to the occurrence of thrombosis formation and intimal hyperplasia after transplantation.Although developing the functional coating with...
关键词:Coaxial extrusion printing Electrostatic self-assembly Sequential release ANTITHROMBOGENICITY ENDOTHELIALIZATION 
具有NO原位催化能力和内皮细胞特异性粘附的小口径血管支架的制备和表征
《离子交换与吸附》2017年第5期395-402,共8页唐笛 李岩冬 梁秦阁 姜力 高靖辰 史杰 王淑芳 
国家重大专项(2017YFC 1103504);国家自然科学基金面上项目(81671842);天津市自然科学基金重点项目(16JCZDJC37600);PCSIRT(No.IRT13023);药物化学生物学国家重点实验室开放基金(201603007)
人工合成的小口径血管支架亟需攻克抗凝血和快速内皮化两大难题。负载有机硒催化剂聚乙烯亚胺(SePEI)能够催化一氧化氮(NO)的原位生成,从而有效地抑制血栓形成。层粘连蛋白来源多肽Tyr-Ile-Gly-Ser-Arg(YIGSR)具有内皮细胞选择性粘附功...
关键词:聚己内酯 含硒聚乙烯亚胺 YIGSR多肽 静电纺丝 人工血管 
Adhesive peptides conjugated PAMAM dendrimer as a coating polymeric material enhancing cell responses被引量:1
《Chinese Chemical Letters》2016年第9期1473-1478,共6页Panita Maturavongsadit Xiangdong Bi Togor A. Gado Yu-Zhe Nie Qian Wang 
financially supported by the NSF-ECCS 1509760;NSF EPSCoR RII Track 1 cooperative agreement awarded to the University of South Carolina (NSF EPSCoR Cooperative Agreement No. EPS-0903795)
This present work aims to functionalize poly(amidoamine) (PAMAM) dendrimers with various reported adhesive peptides, including Arg-Gly-Asp (RGD), Tyr-lle-Gly-Ser-Arg (YIGSR), and Ile-Lys-Val-Ala-Val (IKVAV) ...
关键词:PAMAM dendrimer RGD peptide YIGSR peptide IKVAV peptide Bone marrow mesenchymal stem cells PC12 cells 
五肽YIGSR修饰的半边旗提取物5F脂质体的制备及理化性质研究被引量:2
《中国药房》2016年第13期1842-1844,共3页黄青燕 吕应年 邓小云 刘明星 纪周新 刘琳琳 吴科锋 梁念慈 
广东省自然科学基金项目(No.S2012010008163);广东高校优秀青年创新人才培养计划(No.LYM10083)
目的:制备五肽YIGSR修饰的半边旗提取物5F脂质体(YIGSR-5F-LP)并研究其理化性质。方法:采用薄膜分散-超声法制备5F-LP,以包封率为指标,通过正交试验考察磷脂胆固醇质量比、药脂质量比、超声时间及反应温度对脂质体制备工艺的影响;采用...
关键词:半边旗提取物5F 脂质体 制备工艺 正交试验 包封率 粒径 体外释放度 
Dual-peptide-modified alginate hydrogels for the promotion of angiogenesis被引量:3
《Science China(Information Sciences)》2015年第12期1866-1874,共9页Yanyan Yu Lei Guo Wei Wang Jina Wu Zhi Yuan 
supported by the National Natural Science Foundation of China(51273095);State Key Fundamental R&D Project(2011CB606202);Natural Science Foundation of Tianjin(14JCQNJC03500);Program for Changjiang Scholars and Innovative Research Team in University(IRT1257);National Fund for Fostering Talents of Basic Science(J1103306)
The ability to supply suitable blood vessel system is a major challenge for artificial thick tissue engineering. Angiogenesis is a key point during the process of microvascular formation. Many bioactive molecules such...
关键词:ANGIOGENESIS YIGSR REDV alginate hydrogel thick tissue engineering 
^(99m)Tc-YIGSR as a Receptor Tracer in Imaging the Ehrlich Ascites Tumor-bearing Mice as Compared with ^(99m)Tc-MIBI
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2007年第4期471-474,共4页胡佳 秦光明 张永学 安锐 兰小莉 
This project was supported by a grant from the National Natural Sciences Foundation of China (No 30400170)
The validity of ^99mTc-YIGSR, a novel receptor radio-tracer, in imaging the Ehrlich ascites tumor was evaluated. YIGSR, a pentapeptide of laminin, was labeled with ^99mTc by using a bifunctional chelator S-Acetly-NH3-...
关键词:laminin-YIGSR tumor receptor imaging radio-labeling ^99MTC S-Acetly-NH3-MAG3 
小分子肽^(99m)T_C-YIGSR与^(99m)Tc-MIBI进行肿瘤显像的对比研究
《华中科技大学学报(医学版)》2007年第4期507-509,共3页胡佳 安锐 袁斌 高再荣 曹国祥 张永学 
国家自然科学基金资助项目(No.30400170)
目的将小分子肽YIGSR经99mTc标记后用于肿瘤受体显像并与99mTc-MIBI进行对比。方法①显像剂制备。YIGSR经双功能螯合剂S-Acetyl-MAG3偶联后室温下进行99mTc标记;99mTc-MIBI采用煮沸法制备。②取昆明种小鼠,每只皮下注射1×106埃氏腹水...
关键词:99m^Tc-YIGSR 肿瘤受体显像 放射性核素标记 
YIGSR抑制骨肉瘤细胞分泌MMP-2和MMP-9的实验研究被引量:1
《肿瘤学杂志》2007年第3期192-194,共3页宋登新 陈安民 郭风劲 丁然 胡媛 
国家973计划"恶性肿瘤侵袭和转移的机理及分子阻遏"项目(2002CB513100)
[目的]研究酪氨酸-异亮氨酸-甘氨酸-丝氨酸-精氨酸五肽(YIGSR)对人骨肉瘤细胞MG-63分泌基质金属蛋白酶-2(MMP-2)和基质金属蛋白酶-9(MMP-9)的抑制作用。[方法]在MG-63细胞中加入0、50、100μg/ml的YIGSR,用逆转录聚合酶链式反应(RT-PCR...
关键词:骨肿瘤 酪氨酸 异亮氨酸 甘氨酸 丝氨酸 精氨酸 基质金属蛋白酶-2 基质金属蛋白酶-9 肽类 
^(99m)TC标记Laminin-YIGSR肿瘤小鼠模型显像的实验研究
《华中科技大学学报(医学版)》2006年第5期633-637,F0003,共6页胡佳 秦光明 张永学 兰晓莉 孙逊 
目的探讨99mTc-YIGSR作为一种新型的肿瘤显像剂在埃氏腹水肿瘤受体显像中的应用价值。方法①制备99mTc-MAG3-YIGSR探针,以S-乙基-琥珀酰亚胺-巯乙苷肽(S-Acetly-NHS-MAG3)为螯合剂,将99mTc标记到层黏素多肽片断YIGSR上;②对肿瘤模型组...
关键词:^99mTc—YIGSR 肿瘤受体显像 放射性核素标记 
A Comparative Study of ^(99m)Tc-YIGSR and 99mTc-MIBI Uptake in Tumor Cells
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2005年第6期712-714,共3页胡佳 兰晓莉 张永学 高再荣 伍军 
To investigate a new kind of tumor tracer ^99mTc-YIGSR developed from a five amino structure (YIGSR) of the Laminin -chain, which can bind to the laminin receptors of tumor specifically, and radiolabeled with MAG3. ...
关键词:laminin-YIGSR methoxyisobuty (MIBI-lisonitrile) TUMOR cell uptake ^99MTC 
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