ZONISAMIDE

作品数：7被引量：11H指数：1
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相关领域：医药卫生更多>>
相关作者：王玥朱国行更多>>
相关机构：复旦大学上海医学院更多>>
相关期刊：《中国临床神经科学》《Acta Pharmacologica Sinica》《Neural Regeneration Research》《Journal of Biophysical Chemistry》更多>>
相关基金：广东省自然科学基金更多>>
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Zonisamide attenuates pressure overload-induced myocardial hypertrophy in mice through proteasome inhibition被引量：1
《Acta Pharmacologica Sinica》2024年第4期738-750,共13页Qian Wu Wan-jie Liu Xin-yu Ma Ji-shuo Chang Xiao-ya Zhao Ying-hua Liu Xi-yong Yu 
supported by the National Key Research and Development Program of China(2022YFE0209700);Basic and Applied Basic Research Foundation of Guangzhou city(G23151013);Traditional Chinese Medicine Research Project of Guangdong Province(20241180);First-class Specialty Construction Project of Guangzhou Medical University(02-408-2304-13048XM);Discipline Construction Project of Guangzhou Medical University(02-445-2301192XM,02-445-2301223XM,02-445-2301191XM);Quality Project of Guangdong Province(01-408-2301064XM);Education Reform Project of Guangzhou Medical University(01-408-2301033XM);First-class Specialty Construction Project of Guangzhou Medical University(02-408-2304-13014XM);Research capacity improvement project of Guangzhou Medical University(02-410-2302365XM);Basic and Applied Basic Research Project of Guangzhou city(2023A04J0565).
Myocardial hypertrophy is a pathological thickening of the myocardium which ultimately results in heart failure. We previously reported that zonisamide, an antiepileptic drug, attenuated pressure overload-caused myoca...
关键词：myocardial hypertrophy pressure overload ZONISAMIDE PROTEASOME glycogen synthesis kinase 3(GSK-3) neonatal rat cardiomyocytes angiotensin II 
Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress被引量：1
《Acta Pharmacologica Sinica》2021年第10期1587-1597,共11页Qian Wu Jia-hui Tian Yong-xiang He Yong-yin Huang Yu-qing Huang Gui-ping Zhang Jian-dong Luo Qin Xue Xi-yong Yu Ying-hua Liu 
This work was supported by Natural Science Foundation of Guangdong Province(2014A030313485);Scientific and Technological Planning Program of Guangzhou(2017071010458);Municipal Education Bureau Program of Guangzhou(1201610286);Natural Science Foundation of Guangdong Province(2018A030313719)。
Antiepileptic drug zonisamide has been shown to be curative for Parkinson’s disease(PD)through increasing HMG-CoA reductase degradation protein 1(Hrd1)level and mitigating endoplasmic reticulum(ER)stress.Hrd1 is an E...
关键词：ZONISAMIDE cardiac hypertrophy endoplasmic reticulum stress Hrd1 pressure overload neonatal rat cardiomyocytes(NRCMs) 
Zonisamide,an antiepileptic drug,alleviates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress被引量：10
《Acta Pharmacologica Sinica》2021年第3期393-403,共11页Jia-hui Tian Qian Wu Yong-xiang He Qi-ying Shen Mubarak Rekep Gui-ping Zhang Jian-dong Luo Qin Xue Ying-hua Liu 
supported by Natural Science Foundation of Guangdong Province(2014A030313485);Scientific and Technological Planning Program of Guangzhou(2017071010458);Municipal Education Bureau Program of Guangzhou(1201610286);Guangzhou Education Bureau(1201410365);Natural Science Foundation of Guangdong Province(2018A030313719).
Endoplasmic reticulum stress(ER stress)plays a key role in the development of cardiac hypertrophy and diabetic cardiomyopathy(DCM).Zonisamide(ZNS)was originally developed as an antiepileptic drug.Studies have shown th...
关键词：diabetic cardiomyopathy ZONISAMIDE APOPTOSIS endoplasmic reticulum stress 
Repositioning again of zonisamide for nerve regeneration
《Neural Regeneration Research》2016年第4期541-542,共2页Kinji Ohno Hideki Yagi Bisei Ohkawara 
Zonisamide was kindly provided by Sumitomo Dainippon Pharma Co.,Ltd.,Japan;Studies conducted in the authors’ laboratory were supported by Grants-in-Aid from the MEXT,MHLW,and AMED of Japan
Drug repositioning is a strategy to identify a new application of a pre-approved drug,of which optimal dosage,administration routes,adverse effects,and contraindications are well established.Drug repositioning enables...
Molecular basis of scavenging effect of zonisamide on hydroxyl radical <i>in vitro</i>
《Journal of Biophysical Chemistry》2012年第3期256-258,共3页Ken-ichi Tanaka Takeshi Nanba Tomoyuki Furubayashi Yasuko Noda Luther James Willmore Akitane Mori 
Zonisamide (ZNS), a commonly used anticonvulsant, scavenged hydroxyl radicals at a clinically relevant concentration. Reactants of ZNS with hydrogen peroxide and with hydrogen peroxide plus UV irradiation, yielding hy...
关键词：ZONISAMIDE HYDROXYL RADICALS LC/MS ESR 
2005年悉尼第18届世界神经病学年会信息
《中国临床神经科学》2006年第2期223-224,F0003,共3页王玥 朱国行 
关键词：神经病学 PREGABALIN ZONISAMIDE tiagabine 抗癫痫药物 信息 年会 世界 悉尼 神经系统疾病 
抗癫痫药Zonisamide
《国外医药（合成药．生化药．制剂分册）》1991年第4期237-238,共2页刘庆增 
化学名 1,2-苯并异(口恶)唑-3-甲磺胺药效分类抗癫痫药开发单位大日本制药上市时间 1989年3月20日药理本药对于电击休克和戊四氮唑诱发的小鼠、大妥鼠、兔、狗癫痫症状中的强直性伸展与苯妥英及酰胺咪嗪同样有选择性抑制作用,且持续时...
关键词：抗癫痫药 ZONISAMIDE 药理学 毒性 
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