supported by the National Key Research and Development Program of China(2022YFA1303600 and 2023YFC2308100);the National Natural Science Foundation of China(82130019).
Chronic Hepatitis B Virus(HBV)infection is a major global health issue leading to liver cirrhosis and hepatocellular carcinoma.Currently available treatments have limited efficacy in completely eradicating the virus.
funded in part by the National Institutes of Health(grant numbers:5U01CA180888-08 and 5UG1CA233198-05.)。
4-1BB,a member of the tumor necrosis factor receptor superfamily,is an important co-stimulatory molecule regulating the activity of immune cells across a range of physiological and pathological processes,which culmina...
P30CA016086;NIH S10 Shared Instrumentation Grant,S10OD026951,for supporting this work.
CD28 and 4-1BB costimulatory endodomains included in chimeric antigen receptor(CAR)molecules play a critical role in promoting sustained antitumor activity of CAR-T cells.However,the molecular events associated with t...
This study was supported by the National Research Foundation of Korea(NRF)grant funded by the Korean government(2022R1A2C1005463[BKC],2022R1C1C1010078[SHK],and 2022R1C1C1003152[CH]from MSIT);by the National Cancer Center of Korea(NCC)grant funded by the Ministry of Health and Welfare(NCC-2212450[CH]).
4-1BB is an inducible receptor expressed on activated T cells,while its ligand,4-1BBL,is mainly expressed in antigen-presenting cells and macrophages[1,2].To the best of our knowledge,ligandmediated transactivation of...